End game: Getting the most out of microRNAs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 8, 2011, Pages 3101-3102

  You, Shihyun ^a   Murray, Catherine L ^b   Luna, Joseph M ^b   Rice, Charles M ^b  

^a GLAXOSMITHKLINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 122; RNA INDUCED SILENCING COMPLEX; UNCLASSIFIED DRUG; VIRUS RNA;

CHRONIC LIVER DISEASE; GENE DELETION; GENE REPRESSION; GENE SEQUENCE; GENE TARGETING; HEPATITIS C VIRUS; HUMAN; NORTHERN BLOTTING; NOTE; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA BINDING; VIRUS GENOME; VIRUS REPLICATION;

HEPACIVIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; MICRORNAS;

EID: 79952767148     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1019613108     Document Type: Note

References (20)

1. Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P (2005) Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309:1577-1581. (Pubitemid 41266486)
2. Machlin ES, Sarnow P, Sagan SM (2011) Masking the 5′ terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc Natl Acad Sci USA 108:3193-3198.
3. Jopling CL, Schütz S, Sarnow P (2008) Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome. Cell Host Microbe 4:77-85. (Pubitemid 351944051)
4. Grimson A, et al. (2007) MicroRNA targeting specificity in mammals: Determinants beyond seed pairing. Mol Cell 27:91-105. (Pubitemid 46991392)
5. Hwang HW, Wentzel EA, Mendell JT (2007) A hexanucleotide element directs microRNA nuclear import. Science 315:97-100. (Pubitemid 46196987)
6. Friebe P, Lohmann V, Krieger N, Bartenschlager R (2001) Sequences in the 5′ nontranslated region of hepatitis C virus required for RNA replication. J Virol 75:12047-12057. (Pubitemid 33115877)
7. Luo G, Xin S, Cai Z (2003) Role of the 5′-proximal stem-loop structure of the 5′ untranslated region in replication and translation of hepatitis C virus RNA. J Virol 77:3312-3318. (Pubitemid 36228116)
8. Perez JT, et al. (2010) Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proc Natl Acad Sci USA 107:11525-11530.
9. Umbach JL, Yen HL, Poon LL, Cullen BR (2010) Influenza A virus expresses high levels of an unusual class of small viral leader RNAs in infected cells. MBio 1:e00204-10.
10. Fodor E, Pritlove DC, Brownlee GG (1994) The influenza virus panhandle is involved in the initiation of transcription. J Virol 68:4092-4096. (Pubitemid 24177444)
11. Villordo SM, Gamarnik AV (2009) Genome cyclization as strategy for flavivirus RNA replication. Virus Res 139:230-239.
12. Steil BP, Barton DJ (2009) Cis-active RNA elements (CREs) and picornavirus RNA replication. Virus Res 139:240-252.
13. Henke JI, et al. (2008) microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J 27:3300-3310.
14. Jangra RK, Yi M, Lemon SM (2010) Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol 84:6615-6625.
15. Norman KL, Sarnow P (2010) Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. J Virol 84:666-670.
16. Villanueva RA, et al. (2010) miR-122 does not modulate the elongation phase of hepatitis C virus RNA synthesis in isolated replicase complexes. Antiviral Res 88:119-123.
17. Hornung V, et al. (2006) 5′-Triphosphate RNA is the ligand for RIG-I. Science 314:994-997.
18. Randall G, et al. (2007) Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci USA 104:12884-12889. (Pubitemid 47255249)
19. Wilson JA, Zhang C, Huys A, Richardson CD (2010) Human Ago2 is required for efficient miR-122 regulation of HCV RNA accumulation and translation. J Virol, in press.
20. Lanford RE, et al. (2010) Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327:198-201.