A call for using natural compounds in the development of new antimalarial treatments - An introduction

Malaria Journal

Volumn 10, Issue SUPPL. 1, 2011, Pages

  Ginsburg, Hagai ^a   Deharo, Eric ^b,c  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UMR 152 IRD Universite Paul Sabatier   (France)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (Peru)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETIN; ARTEMISIA ANNUA EXTRACT; ARTEMISININ; ATOVAQUONE; AZITHROMYCIN; CASTICIN; CHLORTETRACYCLINE; CHRYSOPLENETIN; CHRYSOSPLENOL D; CINCHONA ALKALOID; CINCHONIDINE; CINCHONINE; CIRSILINEOL; CLINDAMYCIN; DOXYCYCLINE; DRUG METABOLITE; ERYTHROMYCIN; FLAVONOID; NATURAL PRODUCT; OXYTETRACYCLINE; QUINIDINE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ARTEMISIA ANNUA; BIOCHEMISTRY; BIOSYNTHESIS; CELL THERAPY; CHEMICAL MODIFICATION; CHEMOTHERAPY; COMBINATORIAL CHEMISTRY; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG INDUSTRY; DRUG METABOLISM; DRUG POTENTIATION; DRUG QUALITY; DRUG RESEARCH; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HYDROLYSIS; MALARIA; MEDICINAL PLANT; MULTIDRUG RESISTANCE; NONHUMAN; PATIENT SAFETY; REGULATORY MECHANISM; REVIEW; TRADITIONAL MEDICINE;

ANTIMALARIALS; BIOLOGICAL PRODUCTS; DRUG DISCOVERY; HUMANS; MALARIA; MEDICINE, TRADITIONAL; PLANTS; PLASMODIUM;

EID: 79952763770     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-S1-S1     Document Type: Review

References (44)

1. New medicines to improve control and contribute to the eradication of malaria. TN Wells PL Alonso WE Gutteridge, Nat Rev Drug Discov 2009 8 879 891 10.1038/nrd2972 19834482
2. [Drugs against malaria: What's in the pipeline? Little new in the fight against malaria] (German). M Schlitzer, Pharm Unserer Zeit 2009 38 522 526 10.1002/pauz.200900339 19862720
3. Ethnopharmacology and drug discovery. B Patwardhan, J Ethnopharmacol 2005 100 50 52 10.1016/j.jep.2005.06.006 16023811 (Pubitemid 41073520)
4. Where is the hope for drug discovery? Let history tell the future. DX Kong XJ Li HY Zhang, Drug Discov Today 2009 14 115 119 10.1016/j.drudis.2008.07. 002 18687410
5. Synergy research: approaching a new generation of phytopharmaceuticals. H Wagner G Ulrich-Merzenich, Phytomedicine 2009 16 97 110 10.1016/j.phymed.2008. 12.018 19211237
6. Natural products as sources of new drugs over the last 25 years. DJ Newman GM Cragg, J Nat Prod 2007 70 461 477 10.1021/np068054v 17309302 (Pubitemid 46595760)
7. The impact of natural products upon modern drug discovery. A Ganesan, Curr Opin Chem Biol 2008 12 306 317 10.1016/j.cbpa.2008.03.016 18423384
8. Lessons from natural molecules. J Clardy C Walsh, Nature 2004 432 829 837 10.1038/nature03194 15602548 (Pubitemid 40037138)
9. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. M Feher JM Schmidt, J Chem Inf Comput Sci 2003 43 218 227 12546556
10. Scaffold diversity of natural products: inspiration for combinatorial library design. K Grabowski KH Baringhaus G Schneider, Nat Prod Rep 2008 25 892 904 10.1039/b715668p 18820757
11. Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant. PJ Houghton MJ Howes CC Lee G Steventon, J Ethnopharmacol 2007 110 391 400 10.1016/j.jep.2007.01.032 17317057 (Pubitemid 46394596)
12. Synergy and other interactions in phytomedicines. EM Williamson, Phytomedicine 2001 8 401 409 10.1078/0944-7113-00060 11695885 (Pubitemid 32983062)
13. Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. XH Ma CJ Zheng LY Han B Xie J Jia ZW Cao YX Li YZ Chen, Drug Discov Today 2009 14 579 588 10.1016/j.drudis.2009.03.012 19508920
14. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. G Tegos FR Stermitz O Lomovskaya K Lewis, Antimicrob Agents Chemother 2002 46 3133 3141 10.1128/AAC.46.10.3133-3141.2002 12234835
15. Mechanisms of drug combinations: interaction and network perspectives. J Jia F Zhu X Ma Z Cao Y Li YZ Chen, Nat Rev Drug Discov 2009 8 111 128 10.1038/nrd2683 19180105
16. Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. BC Elford MF Roberts JD Phillipson RJ Wilson, Trans R Soc Trop Med Hyg 1987 81 434 436 10.1016/0035-9203(87)90161-1 3318019
17. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. KCC Liu S Yang MF Roberts BC Elford JD Phillipson, Plant Cell Reports 1992 11 637 640 http://www.springerlink.com/content/9dbedbe6e6a886c0/ 10.1007/BF00236389
18. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. JF Ferreira DL Luthria T Sasaki A Heyerick, Molecules 2010 15 3135 3170 10.3390/molecules15053135 20657468
19. In-vitro response of Plasmodium falciparum to the main alkaloids of Cinchona in northwestern Thailand. A Knauer J Sirichaisinthop FF Reinthaler G Wiedermann G Wernsdorfer WH Wernsdorfer, Wien Klin Wochenschr 2003 115 Suppl 3 39 44 15508779 (Pubitemid 38173310)
20. Activity of a combination of three cinchona bark alkaloids against Plasmodium falciparum in vitro. P Druilhe O Brandicourt T Chongsuphajaisiddhi J Berthe, Antimicrob Agents Chemother 1988 32 250 254 3284455 (Pubitemid 18061384)
21. New perspectives for synergy research with the "omic"- technologies. G Ulrich-Merzenich D Panek H Zeitler H Wagner H Vetter, Phytomedicine 2009 16 495 508 10.1016/j.phymed.2009.04.001 19428231
22. Artemisinin-based combination treatment of falciparum malaria. F Nosten NJ White, Am J Trop Med Hyg 2007 77 181 192 18165491
23. A natural history of botanical therapeutics. B Schmidt DM Ribnicky A Poulev S Logendra WT Cefalu I Raskin, Metabolism 2008 57 3 S9 10.1016/j.metabol.2008.03.001 18555851
24. Drug discovery and development with plant-derived compounds. O Potterat M Hamburger, Prog Drug Res 2008 65 47 118 http://www.ncbi.nlm.nih.gov/pubmed/ 18084913
25. Molecular understanding and modern application of traditional medicines: triumphs and trials. TW Corson CM Crews, Cell 2007 130 769 774 10.1016/j.cell.2007.08.021 17803898 (Pubitemid 47332575)
26. Multicomponent therapeutics for networked systems. CT Keith AA Borisy BR Stockwell, Nat Rev Drug Discov 2005 4 71 78 10.1038/nrd1609 15688074 (Pubitemid 40109591)
27. Synergy in natural medicines: implications for drug discovery. XJ Li HY Zhang, Trends Pharmacol Sci 2008 29 331 332 10.1016/j.tips.2008.04.002 18502520
28. Recent advances in antimalarial compounds and their patents. A Mital, Curr Med Chem 2007 14 759 773 10.2174/092986707780090927 17346161 (Pubitemid 46477710)
29. Recent developments in research on terrestrial plants used for the treatment of malaria. CW Wright, Nat Prod Rep 2010 27 961 968 10.1039/c002196m 20532364
30. Traditional antimalarials and the development of novel antimalarial drugs. CW Wright, J Ethnopharmacol 2005 100 67 71 10.1016/j.jep.2005.05.012 16023812 (Pubitemid 41073524)
31. http://www.who.int/mediacentre/factsheets/fs134/en/
32. Impact of poor-quality medicines in the 'developing' world. PN Newton MD Green FM Fernandez, Trends Pharmacol Sci 2010 31 99 101 10.1016/j.tips.2009.11. 005 20117849
33. Developing ANDI: A Novel Approach to Health Product R&D in Africa. S Nwaka TB Ilunga JS Da Silva, et al. PLoS Med 2010 7 1000293 10.1371/journal. pmed.1000293 20613865
34. http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/ GuidanceDocuments/FoodLabelingNutrition/ucm053843.htm
35. Revisiting the ancient concept of botanical therapeutics. BM Schmidt DM Ribnicky PE Lipsky I Raskin, Nat Chem Biol 2007 3 360 366 10.1038/nchembio0707- 360 17576417 (Pubitemid 46956331)
36. Antiparasitic properties of medicinal plants and other naturally occurring products. S Tagboto S Townson, Adv Parasitol 2001 50 199 295 full-text 11757332 (Pubitemid 33086304)
37. Antimalarial activity of plant metabolites. S Schwikkard FR van Heerden, Nat Prod Rep 2002 19 675 692 10.1039/b008980j 12521264 (Pubitemid 36029226)
38. Antimalarial agents from plant sources. S Saxena N Pant DC Jain RS Bhakuni, Current Science 2003 85 1314 1329 http://www.ias.ac.in/currsci/ nov102003/1314.pdf (Pubitemid 39204545)
39. Potential antimalarial activity of indole alkaloids. M Frederich M Tits L Angenot, Trans R Soc Trop Med Hyg 2008 102 11 19 10.1016/j.trstmh.2007.10.002 18035385 (Pubitemid 350177430)
40. Investigating South African plants as a source of new antimalarial drugs. P Pillay VJ Maharaj PJ Smith, J Ethnopharmacol 2008 119 438 454 10.1016/j.jep.2008.07.003 18687395
41. Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products. R Batista AJ Silva Jr. AB de Oliveira, Molecules 2009 14 3037 3072 10.3390/molecules14083037 19701144
42. Antimalarials from nature. K Kaur M Jain T Kaur R Jain, Bioorg Med Chem 2009 17 3229 3256 10.1016/j.bmc.2009.02.050 19299148
43. Plants of the American continent with antimalarial activity. IR Mariath HS Falco JM Barbosa-Filho LCF Sousa ACA Tomaz LM Batista MFMF Diniz PF Athayde-Filho JF Tavares MS Silva EVL Cunha, Braz J Pharmacogn 2009 19 158 192
44. Antimalarial compounds isolated from plants used in traditional medicine. J Bero M Frederich J Quetin-Leclercq, J Pharm Pharmacol 2009 61 1401 1433 10.1211/jpp.61.11.0001 19903367