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Volumn 4, Issue 2, 2011, Pages 197-205

Clinical pharmacology and efficacy of inhaled iloprost for the treatment of pulmonary arterial hypertension

Author keywords

arachidonic acid metabolite; iloprost; prostacyclin; prostaglandin; pulmonary arterial hypertension

Indexed keywords

ADENOSINE; ANTICOAGULANT AGENT; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; CYCLIC AMP; DIGOXIN; ENDOTHELIN 1; ILOPROST; NITRIC OXIDE; PLACEBO; PROSTACYCLIN; PROSTAGLANDIN E1; SEROTONIN; SILDENAFIL; THROMBOXANE; TYVASO; UNCLASSIFIED DRUG; UNIPROST;

EID: 79952763662     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/ecp.10.136     Document Type: Review
Times cited : (4)

References (67)
  • 1
    • 4143111667 scopus 로고    scopus 로고
    • Diagnosis and management of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    • Rubin LJ. Diagnosis and management of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 126(1 Suppl.), 7S-10S (2004).
    • (2004) Chest , vol.126 , Issue.1 SUPPL.
    • Rubin, L.J.1
  • 2
    • 2942603006 scopus 로고    scopus 로고
    • Diagnosis and differential assessment of pulmonary arterial hypertension
    • Barst RJ, McGoon M, Torbicki A et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43(12 Suppl.), S40-S47 (2004).
    • (2004) J. Am. Coll. Cardiol. , vol.43 , Issue.12 SUPPL.
    • Barst, R.J.1    McGoon, M.2    Torbicki, A.3
  • 3
    • 79952766980 scopus 로고    scopus 로고
    • ACCF/AHA 2009 expert consensus document on pulmonary hypertension: A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents
    • McLaughlin VV, Archer SL, Badesch DB et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J. Am. Coll. Cardiol. 53, 1-43 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 1-43
    • McLaughlin, V.V.1    Archer, S.L.2    Badesch, D.B.3
  • 4
    • 39749173306 scopus 로고    scopus 로고
    • Advances in diagnosis and treatment in patients with pulmonary arterial hypertension
    • Park MH. Advances in diagnosis and treatment in patients with pulmonary arterial hypertension. Catheter Cardiovascular Intervention 71(2), 205-213 (2008).
    • (2008) Catheter Cardiovascular Intervention , vol.71 , Issue.2 , pp. 205-213
    • Park, M.H.1
  • 5
    • 13444279874 scopus 로고    scopus 로고
    • Pathogenesis of pulmonary arterial hypertension: The need for multiple hits
    • Yuan JXJ, Rubin LJ. Pathogenesis of pulmonary arterial hypertension: the need for multiple hits. Circulation 111, 534-538 (2005).
    • (2005) Circulation , vol.111 , pp. 534-538
    • Yuan, J.X.J.1    Rubin, L.J.2
  • 6
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension: A national prospective study
    • Rich S, Dantzker DR, Ayres SM et al. Primary pulmonary hypertension: a national prospective study. Ann. Intern. Med. 107, 216-223 (1987).
    • (1987) Ann. Intern. Med. , vol.107 , pp. 216-223
    • Rich, S.1    Dantzker, D.R.2    Ayres, S.M.3
  • 7
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension
    • D'Alonzo GE, Barst RJ, Ayres SM et al. Survival in patients with primary pulmonary hypertension. Ann. Intern. Med. 115, 343-349 (1991).
    • (1991) Ann. Intern. Med. , vol.115 , pp. 343-349
    • D'Alonzo, G.E.1    Barst, R.J.2    Ayres, S.M.3
  • 8
    • 33847271175 scopus 로고    scopus 로고
    • Epidemiology of pulmonary arterial hypertension
    • Taichman DB, Mandel J. Epidemiology of pulmonary arterial hypertension. Clin. Chest Med. 23(1), 1-22 (2007).
    • (2007) Clin. Chest Med. , vol.23 , Issue.1 , pp. 1-22
    • Taichman, D.B.1    Mandel, J.2
  • 9
    • 37549033243 scopus 로고    scopus 로고
    • A USA-based registry for pulmonary arterial hypertension: 1982-2006
    • Thenappan T, Shah SJ, Rich S. A USA-based registry for pulmonary arterial hypertension: 1982-2006. Eur. Respir. J. 30, 1103-1110 (2007).
    • (2007) Eur. Respir. J. , vol.30 , pp. 1103-1110
    • Thenappan, T.1    Shah, S.J.2    Rich, S.3
  • 10
    • 40949145735 scopus 로고    scopus 로고
    • Update in pulmonary arterial hypertension 2007
    • Humber M. Update in pulmonary arterial hypertension 2007. Am. J. Respir. Crit. Care Med. 177, 574-579 (2008).
    • (2008) Am. J. Respir. Crit. Care Med. , vol.177 , pp. 574-579
    • Humber, M.1
  • 12
    • 33748931278 scopus 로고    scopus 로고
    • Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension
    • Channick RN, Olschewski H, Seeger W et al. Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension. J. Am. Coll. Cardiol. 48, 1433-1437 (2006).
    • (2006) J. Am. Coll. Cardiol. , vol.48 , pp. 1433-1437
    • Channick, R.N.1    Olschewski, H.2    Seeger, W.3
  • 13
    • 50849116416 scopus 로고    scopus 로고
    • Acute effects of the combination of sildenafil and inhaled treprostinil on hemodynamics and gas exchange in pulmonary hypertension
    • Voswinckel R, Reichenberger F, Enke B et al. Acute effects of the combination of sildenafil and inhaled treprostinil on hemodynamics and gas exchange in pulmonary hypertension. Pulm. Pharmacol. Ther. 21, 824-832 (2008).
    • (2008) Pulm. Pharmacol. Ther. , vol.21 , pp. 824-832
    • Voswinckel, R.1    Reichenberger, F.2    Enke, B.3
  • 14
    • 77952301237 scopus 로고    scopus 로고
    • Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: A randomized controlled clinical trial
    • McLaughlin V, Benza RL, Rubin LJ et al. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. J. Am. Coll. Cardiol. 55, 1915-1922 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 1915-1922
    • McLaughlin, V.1    Benza, R.L.2    Rubin, L.J.3
  • 15
    • 68949145840 scopus 로고    scopus 로고
    • Inhalative iloprost-pharmacology and clinical application
    • Ewert R, Schaper C, Halank M et al. Inhalative iloprost-pharmacology and clinical application. Expert Opin. Pharmacother. 10(13), 1-13 (2009).
    • (2009) Expert Opin. Pharmacother. , vol.10 , Issue.13 , pp. 1-13
    • Ewert, R.1    Schaper, C.2    Halank, M.3
  • 16
    • 42549161100 scopus 로고    scopus 로고
    • Prostacyclin among prostanoids
    • Gryglewski RJ. Prostacyclin among prostanoids. Pharmacol. Rep. 60, 3-11 (2008).
    • (2008) Pharmacol. Rep. , vol.60 , pp. 3-11
    • Gryglewski, R.J.1
  • 17
    • 1942502821 scopus 로고    scopus 로고
    • Prostanoids and prostanoid receptors in signal transduction
    • Bos CL, Richel DJ, Ritsema T et al. Prostanoids and prostanoid receptors in signal transduction. Int. J. Biochem. Cell Biol. 36, 1187-1205 (2004).
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1187-1205
    • Bos, C.L.1    Richel, D.J.2    Ritsema, T.3
  • 18
    • 73749086478 scopus 로고    scopus 로고
    • A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension
    • Mubarak KK. A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension. Respir. Med. 104(1), 9-21 (2009).
    • (2009) Respir. Med. , vol.104 , Issue.1 , pp. 9-21
    • Mubarak, K.K.1
  • 19
    • 0036200014 scopus 로고    scopus 로고
    • Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation
    • Beghetti M, Reber G, de Moerloose P et al. Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation. Eur. Respir. J. 19(3), 518-524 (2002).
    • (2002) Eur. Respir. J. , vol.19 , Issue.3 , pp. 518-524
    • Beghetti, M.1    Reber, G.2    De Moerloose, P.3
  • 20
    • 0023113278 scopus 로고
    • Comparison of equimolar concentrations of iloprost, prostacyclin, and prostaglandin E1 on human platelet function
    • Fischer CA, Kappa JR, Sinha AK et al. Comparison of equimolar concentrations of iloprost, prostacyclin, and prostaglandin E1 on human platelet function. J. Lab. Clin. Med. 109(2), 184 (1987).
    • (1987) J. Lab. Clin. Med. , vol.109 , Issue.2 , pp. 184
    • Fischer, C.A.1    Kappa, J.R.2    Sinha, A.K.3
  • 21
    • 3142777629 scopus 로고    scopus 로고
    • Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    • McLaughlin VV, Presberg KW, Doyle RL et al. Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 126, 78-92 (2004).
    • (2004) Chest , vol.126 , pp. 78-92
    • McLaughlin, V.V.1    Presberg, K.W.2    Doyle, R.L.3
  • 22
    • 34250870730 scopus 로고    scopus 로고
    • Medical therapy for pulmonary arterial hypertension: Updated ACCP evidence-based clinical practice guidelines
    • Badesch DB, Abman SH, Simonneau G. Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines. Chest 131, 1917-1928 (2007).
    • (2007) Chest , vol.131 , pp. 1917-1928
    • Badesch, D.B.1    Abman, S.H.2    Simonneau, G.3
  • 23
    • 0035257706 scopus 로고    scopus 로고
    • Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension
    • Nagaya N, Nishikimi T, Uematsu M et al. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. J. Cardiol. 37, 110-111 (2001).
    • (2001) J. Cardiol. , vol.37 , pp. 110-111
    • Nagaya, N.1    Nishikimi, T.2    Uematsu, M.3
  • 24
    • 21544465866 scopus 로고    scopus 로고
    • Screening, early detection, and diagnosis of pulmonary arterial hypertension
    • McGoon M, Gutterman D, Steen V et al. Screening, early detection, and diagnosis of pulmonary arterial hypertension. Chest 126, 145-305 (2004).
    • (2004) Chest , vol.126 , pp. 145-305
    • McGoon, M.1    Gutterman, D.2    Steen, V.3
  • 25
    • 79952754673 scopus 로고    scopus 로고
    • Physiological basis of respiratory disease
    • Qutayba H, Shannon J, Martin J. Physiological basis of respiratory disease. Eur. Respir. J. 27, 243 (2006).
    • (2006) Eur. Respir. J. , vol.27 , pp. 243
    • Qutayba, H.1    Shannon, J.2    Martin, J.3
  • 26
    • 33748998458 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Mclaughlin V, McGoon M. Pulmonary arterial hypertension. Circulation 114(13), 1417-1431 (2006).
    • (2006) Circulation , vol.114 , Issue.13 , pp. 1417-1431
    • Mclaughlin, V.1    McGoon, M.2
  • 27
    • 0033977505 scopus 로고    scopus 로고
    • A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension
    • German PPH study group
    • Hoeper MM, Olschewski H, Ghofrani HA et al. A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group. J. Am. Coll. Cardiol. 35, 176-182 (2000).
    • (2000) J. Am. Coll. Cardiol. , vol.35 , pp. 176-182
    • Hoeper, M.M.1    Olschewski, H.2    Ghofrani, H.A.3
  • 28
    • 0037322944 scopus 로고    scopus 로고
    • Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost admininstered by either infusion or inhalation
    • Opitz CF, Wensel R, Bettmann M et al. Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost admininstered by either infusion or inhalation. Eur. Heart J. 24, 356-365 (2003).
    • (2003) Eur. Heart J. , vol.24 , pp. 356-365
    • Opitz, C.F.1    Wensel, R.2    Bettmann, M.3
  • 29
    • 0036252810 scopus 로고    scopus 로고
    • Hemodynamic effects of aerosolized iloprost in pulmonary hypertension at rest and during exercise
    • Blumberg FC, Riegger GAJ, Pfeifer M. Hemodynamic effects of aerosolized iloprost in pulmonary hypertension at rest and during exercise. Chest 121, 1566-1571 (2002).
    • (2002) Chest , vol.121 , pp. 1566-1571
    • Blumberg, F.C.1    Riegger, G.A.J.2    Pfeifer, M.3
  • 30
    • 0021919098 scopus 로고
    • Effects of prostacyclin and of the stable prostacyclin analogue ZK 36374 on forearm blood flow and blood platelet behavior in man
    • Cowley AJ, Heptinstall S, Hamptom JR. Effects of prostacyclin and of the stable prostacyclin analogue ZK 36374 on forearm blood flow and blood platelet behavior in man. J. Thromb. Haemost. 53(1), 90-94 (1985).
    • (1985) J. Thromb. Haemost. , vol.53 , Issue.1 , pp. 90-94
    • Cowley, A.J.1    Heptinstall, S.2    Hamptom, J.R.3
  • 31
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled iloprost for severe pulmonary hypertension
    • Olschewski H, Simonneau G, Galie N et al. Inhaled iloprost for severe pulmonary hypertension. N. Engl. J. Med. 347, 322-329 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 322-329
    • Olschewski, H.1    Simonneau, G.2    Galie, N.3
  • 32
    • 0034949385 scopus 로고    scopus 로고
    • Long-term treatment of pulmonary hypertension with aerosolized iloprost
    • Macherndl S, Kneussl M, Baumgartner H et al. Long-term treatment of pulmonary hypertension with aerosolized iloprost. Eur. Respir. J. 17(1) 8-13 (2001).
    • (2001) Eur. Respir. J. , vol.17 , Issue.1 , pp. 8-13
    • Macherndl, S.1    Kneussl, M.2    Baumgartner, H.3
  • 33
    • 33847368988 scopus 로고    scopus 로고
    • Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
    • Hoeper MM, Leuchte H, Halank M et al. Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur. Respir. J. 28, 691-694 (2006).
    • (2006) Eur. Respir. J. , vol.28 , pp. 691-694
    • Hoeper, M.M.1    Leuchte, H.2    Halank, M.3
  • 34
    • 21544449424 scopus 로고    scopus 로고
    • Clinical efficacy and survival with inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension
    • Opitz CF, Wensel R, Winkler R et al. Clinical efficacy and survival with inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur. Heart J. 26, 1895-1902 (2005).
    • (2005) Eur. Heart J. , vol.26 , pp. 1895-1902
    • Opitz, C.F.1    Wensel, R.2    Winkler, R.3
  • 35
    • 0036007307 scopus 로고    scopus 로고
    • Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery
    • Clapp LH, Finney P, Turcato S et al. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am. J. Respir. Cell Mol. Biol. 26(2), 194-201 (2002).
    • (2002) Am. J. Respir. Cell Mol. Biol. , vol.26 , Issue.2 , pp. 194-201
    • Clapp, L.H.1    Finney, P.2    Turcato, S.3
  • 36
    • 0036827794 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs
    • Schermuly RT, Schulz A, Ghofrani HA et al. Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs. J. Pharmacol. Exp. Ther. 303(2), 741-745 (2002).
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , Issue.2 , pp. 741-745
    • Schermuly, R.T.1    Schulz, A.2    Ghofrani, H.A.3
  • 37
    • 0034954724 scopus 로고    scopus 로고
    • Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension
    • Gessler T, Schmehl T, Hoper MM et al. Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. Eur. Respir. J. 17, 14-19 (2001).
    • (2001) Eur. Respir. J. , vol.17 , pp. 14-19
    • Gessler, T.1    Schmehl, T.2    Hoper, M.M.3
  • 38
    • 2542438681 scopus 로고    scopus 로고
    • Prostacyclin and its analogues in the treatment of pulmonary hypertension
    • Olschewski H, Rose F, Scermuly R et al. Prostacyclin and its analogues in the treatment of pulmonary hypertension. Pharmacol. Ther. 102, 139-153 (2004).
    • (2004) Pharmacol. Ther. , vol.102 , pp. 139-153
    • Olschewski, H.1    Rose, F.2    Scermuly, R.3
  • 39
    • 0026681422 scopus 로고
    • Iloprost: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischemia and extracorporeal circulation procedures
    • Grant SM, Goa KL. Iloprost: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischemia and extracorporeal circulation procedures. Drugs 43(6) 889-924 (1992).
    • (1992) Drugs , vol.43 , Issue.6 , pp. 889-924
    • Grant, S.M.1    Goa, K.L.2
  • 40
    • 1842739572 scopus 로고    scopus 로고
    • Inhaled iloprost in primary pulmonary hypertension
    • Goldsmith DR, Wagstaff JA. Inhaled iloprost in primary pulmonary hypertension. Drugs 64, 763-773 (2004).
    • (2004) Drugs , vol.64 , pp. 763-773
    • Goldsmith, D.R.1    Wagstaff, J.A.2
  • 41
    • 0023247304 scopus 로고
    • Pharmacokinetics and pharmacodynamics of radio-labeled iloprost in elderly volunteers
    • Krause W, Krais T. Pharmacokinetics and pharmacodynamics of radio-labeled iloprost in elderly volunteers. Eur. J. Clin. Pharmacol. 32, 597-605 (1987).
    • (1987) Eur. J. Clin. Pharmacol. , vol.32 , pp. 597-605
    • Krause, W.1    Krais, T.2
  • 42
    • 0142074258 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices in severe pulmonary hypertension
    • Olschewski H, Rohde B, Behr J et al. Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices in severe pulmonary hypertension. Chest 124, 1294-1304 (2003).
    • (2003) Chest , vol.124 , pp. 1294-1304
    • Olschewski, H.1    Rohde, B.2    Behr, J.3
  • 43
    • 0029993602 scopus 로고    scopus 로고
    • Aerosolized prostacyclin and iloprost in severe pulmonary hypertension
    • Olschewski H, Walmrath D, Schermuly R et al. Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann. Intern. Med. 124, 820-824 (1996).
    • (1996) Ann. Intern. Med. , vol.124 , pp. 820-824
    • Olschewski, H.1    Walmrath, D.2    Schermuly, R.3
  • 44
    • 0034702248 scopus 로고    scopus 로고
    • Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue
    • Hoeper MM, Schwarze M, Ehlerding S et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N. Engl. J. Med. 342, 1866-1870 (2000).
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1866-1870
    • Hoeper, M.M.1    Schwarze, M.2    Ehlerding, S.3
  • 47
    • 6444229321 scopus 로고    scopus 로고
    • Intravenous iloprost bridging to orthotopic liver transplantation in portopulmonary hypertension
    • Minder S, Fischler M, Muellhaupt B et al. Intravenous iloprost bridging to orthotopic liver transplantation in portopulmonary hypertension. Eur. Respir. J. 24, 703-707 (2004).
    • (2004) Eur. Respir. J. , vol.24 , pp. 703-707
    • Minder, S.1    Fischler, M.2    Muellhaupt, B.3
  • 48
    • 0025678442 scopus 로고
    • Pharmacokinetics of iloprost in patients with chronic renal failure and on maintenance hemodialysis
    • Hildebrand M, Krause W, Fabian H et al. Pharmacokinetics of iloprost in patients with chronic renal failure and on maintenance hemodialysis. Int. J. Clin. Pharmacol. Res. 10, 285-292 (1990).
    • (1990) Int. J. Clin. Pharmacol. Res. , vol.10 , pp. 285-292
    • Hildebrand, M.1    Krause, W.2    Fabian, H.3
  • 49
    • 67449102429 scopus 로고    scopus 로고
    • Review of inhaled iloprost for the control of pulmonary arterial hypertension in children
    • Tissot C, Beghetti M. Review of inhaled iloprost for the control of pulmonary arterial hypertension in children. Vasc. Health Risk Manag. 5, 325-331 (2009).
    • (2009) Vasc. Health Risk Manag. , vol.5 , pp. 325-331
    • Tissot, C.1    Beghetti, M.2
  • 50
    • 34548800378 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension in pregnancy
    • Huang S, Desantis ERH. Treatment of pulmonary arterial hypertension in pregnancy. Am. J. Health Syst Pharm. 64, 1922-1925 (2007).
    • (2007) Am. J. Health Syst Pharm. , vol.64 , pp. 1922-1925
    • Huang, S.1    Desantis, E.R.H.2
  • 52
    • 44149096954 scopus 로고    scopus 로고
    • Comparison of inhaled iloprost and nitric oxide in patients with pulmonary hypertension during weaning from cardiopulmonary bypass in cardiac surgery: A prospective randomized trial
    • Winterhalter M, Simon A, Fischer S et al. Comparison of inhaled iloprost and nitric oxide in patients with pulmonary hypertension during weaning from cardiopulmonary bypass in cardiac surgery: a prospective randomized trial. J. Cardiothorac. Vasc. Anesth. 22, 406-413 (2008).
    • (2008) J. Cardiothorac. Vasc. Anesth. , vol.22 , pp. 406-413
    • Winterhalter, M.1    Simon, A.2    Fischer, S.3
  • 53
    • 17944376566 scopus 로고    scopus 로고
    • Aerosolized iloprost improves pulmonary hemodynamics in patients with primary pulmonary hypertension receiving continuous epoprostenol treatment
    • Petkov V, Ziesche R, Mosgoeller W et al. Aerosolized iloprost improves pulmonary hemodynamics in patients with primary pulmonary hypertension receiving continuous epoprostenol treatment. Thorax 56, 734-736 (2001).
    • (2001) Thorax , vol.56 , pp. 734-736
    • Petkov, V.1    Ziesche, R.2    Mosgoeller, W.3
  • 54
    • 33845526777 scopus 로고    scopus 로고
    • Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
    • McLaughlin VV, Oudiz RJ, Frost A et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 174, 1257-1263 (2006).
    • (2006) Am. J. Respir. Crit. Care Med. , vol.174 , pp. 1257-1263
    • McLaughlin, V.V.1    Oudiz, R.J.2    Frost, A.3
  • 55
    • 61649096423 scopus 로고    scopus 로고
    • Inhaled iloprost for the treatment of pulmonary hypertension
    • Olschewski H. Inhaled iloprost for the treatment of pulmonary hypertension. Eur. Respir. Rev. 18, 2-34 (2009).
    • (2009) Eur. Respir. Rev. , vol.18 , pp. 2-34
    • Olschewski, H.1
  • 56
    • 77951621266 scopus 로고    scopus 로고
    • Long-term therapy with inhaled iloprost in patients with pulmonary hypertension
    • Olschewski H, Hoper MM, Behr J et al. Long-term therapy with inhaled iloprost in patients with pulmonary hypertension. Respir. Med. 2010 104, 731-740 (2004).
    • (2004) Respir. Med. , vol.2010 , Issue.104 , pp. 731-740
    • Olschewski, H.1    Hoper, M.M.2    Behr, J.3
  • 57
    • 17444422003 scopus 로고    scopus 로고
    • Long-term survival in patients with pulmonary hypertension inhaling iloprost
    • abstract 2567
    • Olschewski H, Nikkho S, Behr J et al. Long-term survival in patients with pulmonary hypertension inhaling iloprost. Eur. Heart J. 24, 482 (abstract 2567) (2003).
    • (2003) Eur. Heart J. , vol.24 , pp. 482
    • Olschewski, H.1    Nikkho, S.2    Behr, J.3
  • 58
    • 1042263812 scopus 로고    scopus 로고
    • Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension
    • Ghofrani HA, Friese G, Discher T et al. Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension. Eur. Respir. J. 23, 321-326 (2004).
    • (2004) Eur. Respir. J. , vol.23 , pp. 321-326
    • Ghofrani, H.A.1    Friese, G.2    Discher, T.3
  • 59
    • 73949102022 scopus 로고    scopus 로고
    • Treatment and outcome of pulmonary arterial hypertension in HIV-infected patients: A review of the literature
    • Cicalili S, Chinello P, Grilli E, Petrosillo N. Treatment and outcome of pulmonary arterial hypertension in HIV-infected patients: a review of the literature. Curr. HIV Res. 7, 589-596 (2009).
    • (2009) Curr. HIV Res. , vol.7 , pp. 589-596
    • Cicalili, S.1    Chinello, P.2    Grilli, E.3    Petrosillo, N.4
  • 60
    • 55249102429 scopus 로고    scopus 로고
    • HIV-related pulmonary arterial hypertension: Clinical presentation and management
    • Sitbon O. HIV-related pulmonary arterial hypertension: clinical presentation and management. AIDS 22, S55-S62 (2008).
    • (2008) AIDS , vol.22
    • Sitbon, O.1
  • 61
    • 84866026195 scopus 로고    scopus 로고
    • Accessed 6 September
    • The US FDA Center for Evaluation and Research. Tyvaso www.fda.gov/Drugs/NewsEvents/ UCM130961 (Accessed 6 September 2010)
    • (2010) Tyvaso
  • 63
    • 84866012701 scopus 로고    scopus 로고
    • Accessed 21 January 2010
    • The US FDA Center for Evaluation and Research. Ventavis www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search. DrugDetails (Accessed 21 January 2010)
    • Ventavis
  • 64
    • 84866037152 scopus 로고    scopus 로고
    • site for New Zealand Accessed 21 January 2010
    • Medsafe site for New Zealand www.medsafe.govt.nz (Accessed 21 January 2010)
  • 65
    • 84866047007 scopus 로고    scopus 로고
    • The European Agency for the Evaluation of Medicinal Products Accessed 21 January 2010
    • The European Agency for the Evaluation of Medicinal Products. Ventavis: summary of product characteristics www.ema.europa.eu/ema/index.jsp?curl=pages/ medicines/human/medicines/000474/human-med-001133.jsp&mid= WC0b01ac058001d125&murl=menus/medicines/medicines.jsp&jsenabled=true (Accessed 21 January 2010)
    • Ventavis: Summary of Product Characteristics
  • 66
    • 84866017569 scopus 로고    scopus 로고
    • Accessed 21 January 2010
    • Ventavis (iloprost) package insert www.4ventavis.com/pdf/Vent- PromoPIUpdate6-10-VV6334.pdf (Accessed 21 January 2010)
    • Ventavis (Iloprost) Package Insert
  • 67
    • 84866035208 scopus 로고    scopus 로고
    • Adverse Drug Reaction published by the Health Products Regulation Group, and the HAS Pharmacovigilance Advisory Committee Accessed 21 January 2010
    • Adverse Drug Reaction published by the Health Products Regulation Group, HAS and the HAS Pharmacovigilance Advisory Committee www.hsa.gov.sg/publish/ hsaportal/en/health-products-regulation/safety-information/pharmacovigilance. html (Accessed 21 January 2010)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.