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Volumn 64, Issue 7, 2004, Pages 763-773

Inhaled iloprost: In primary pulmonary hypertension

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADRENALIN; COLLAGEN; ILOPROST; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; PLACEBO; PROSTACYCLIN; SILDENAFIL; TOLAFENTRINE; UNCLASSIFIED DRUG;

EID: 1842739572     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200464070-00009     Document Type: Review
Times cited : (29)

References (37)
  • 1
    • 0036707922 scopus 로고    scopus 로고
    • Current and emerging therapy for primary pulmonary hypertension
    • Sep
    • Pass SE, Dusing ML. Current and emerging therapy for primary pulmonary hypertension. Ann Pharmacother 2002 Sep; 36 (9): 1414-23
    • (2002) Ann Pharmacother , vol.36 , Issue.9 , pp. 1414-1423
    • Pass, S.E.1    Dusing, M.L.2
  • 2
    • 0032578279 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • published erratum appears in Lancet 1999 Jan 2; 353: 74. Aug 29
    • Gaine SP, Rubin LJ. Primary pulmonary hypertension [published erratum appears in Lancet 1999 Jan 2; 353: 74]. Lancet 1998 Aug 29; 352: 719-25
    • (1998) Lancet , vol.352 , pp. 719-725
    • Gaine, S.P.1    Rubin, L.J.2
  • 3
    • 0037623284 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • May 3
    • Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet 2003 May 3; 361: 1533-44
    • (2003) Lancet , vol.361 , pp. 1533-1544
    • Runo, J.R.1    Loyd, J.E.2
  • 4
    • 0036174808 scopus 로고    scopus 로고
    • Current management of primary pulmonary hypertension
    • De Backer TLM, Smedema J-P, Carlier SG. Current management of primary pulmonary hypertension. Biodrugs 2001; 15 (12): 801-17
    • (2001) Biodrugs , vol.15 , Issue.12 , pp. 801-817
    • De Backer, T.L.M.1    Smedema, J.-P.2    Carlier, S.G.3
  • 5
    • 0035233485 scopus 로고    scopus 로고
    • Current management of primary pulmonary hypertension
    • Klings ES, Farber HW. Current management of primary pulmonary hypertension. Drugs 2001; 61 (13): 1945-56
    • (2001) Drugs , vol.61 , Issue.13 , pp. 1945-1956
    • Klings, E.S.1    Farber, H.W.2
  • 6
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension: The Primary Pulmonary Hypertension Study Group
    • Feb 1
    • Barst RJ, Rubin LJ, Long WA, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension: the Primary Pulmonary Hypertension Study Group. N Engl J Med 1996 Feb 1; 334 (5): 296-301
    • (1996) N Engl J Med , vol.334 , Issue.5 , pp. 296-301
    • Barst, R.J.1    Rubin, L.J.2    Long, W.A.3
  • 7
    • 0026681422 scopus 로고
    • Iloprost: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures
    • Jun
    • Grant SM, Goa KL. Iloprost: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures. Drugs 1992 Jun; 43 (6): 889-924
    • (1992) Drugs , vol.43 , Issue.6 , pp. 889-924
    • Grant, S.M.1    Goa, K.L.2
  • 8
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled iloprost for severe pulmonary hypertension
    • Aug 1
    • Olschewski H, Simonneau G, Galiè N, et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 2002 Aug 1; 347 (5): 322-9
    • (2002) N Engl J Med , vol.347 , Issue.5 , pp. 322-329
    • Olschewski, H.1    Simonneau, G.2    Galiè, N.3
  • 9
    • 0036007307 scopus 로고    scopus 로고
    • Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery
    • Feb
    • Clapp LH, Finney P, Turcato S, et al. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am J Respir Cell Mol Biol 2002 Feb; 26 (2): 194-201
    • (2002) Am J Respir Cell Mol Biol , vol.26 , Issue.2 , pp. 194-201
    • Clapp, L.H.1    Finney, P.2    Turcato, S.3
  • 10
    • 0034811552 scopus 로고    scopus 로고
    • Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: Response to iloprost inhalation
    • Oct
    • Wiedemann R, Ghofrani HA, Weissmann N, et al. Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation. J Am Coll Cardiol 2001 Oct; 38 (4): 1130-6
    • (2001) J Am Coll Cardiol , vol.38 , Issue.4 , pp. 1130-1136
    • Wiedemann, R.1    Ghofrani, H.A.2    Weissmann, N.3
  • 11
    • 0037465729 scopus 로고    scopus 로고
    • Influence of inhaled iloprost on transpulmonary gradient of big endothelin in patients with pulmonary hypertension
    • Mar 25
    • Wilkens H, Bauer M, Forestier N, et al. Influence of inhaled iloprost on transpulmonary gradient of big endothelin in patients with pulmonary hypertension. Circulation 2003 Mar 25; 107 (11): 1509-13
    • (2003) Circulation , vol.107 , Issue.11 , pp. 1509-1513
    • Wilkens, H.1    Bauer, M.2    Forestier, N.3
  • 12
    • 0142074258 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerolized by three different devices in severe pulmonary hypertension
    • Oct
    • Olschewski H, Rohde B, Behr J, et al. Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerolized by three different devices in severe pulmonary hypertension. Chest 2003 Oct; 124 (4): 1294-304
    • (2003) Chest , vol.124 , Issue.4 , pp. 1294-1304
    • Olschewski, H.1    Rohde, B.2    Behr, J.3
  • 13
    • 0033977505 scopus 로고    scopus 로고
    • A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension: German PPH study group
    • Jan
    • Hoeper MM, Olschewski H, Ghofrani HA, et al. A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension: German PPH study group. J Am Coll Cardiol 2000 Jan; 35 (1): 176-82
    • (2000) J Am Coll Cardiol , vol.35 , Issue.1 , pp. 176-182
    • Hoeper, M.M.1    Olschewski, H.2    Ghofrani, H.A.3
  • 14
    • 0036800014 scopus 로고    scopus 로고
    • The new clinical trials on pharmacological treatment in pulmonary arterial hypertension
    • Oct
    • Galiè N, Manes A, Branzi A. The new clinical trials on pharmacological treatment in pulmonary arterial hypertension. Eur Respir J 2002 Oct; 20 (4): 1037-49
    • (2002) Eur Respir J , vol.20 , Issue.4 , pp. 1037-1049
    • Galiè, N.1    Manes, A.2    Branzi, A.3
  • 15
    • 0034696634 scopus 로고    scopus 로고
    • Inhaled iloprost to treat severe pulmonary hypertension: An uncontrolled trial
    • German PPH Study Group. Mar 21
    • Olschewski H, Ghofrani HA, Schmehl T, et al. Inhaled iloprost to treat severe pulmonary hypertension: an uncontrolled trial. German PPH Study Group. Ann Intern Med 2000 Mar 21; 132 (6): 435-43
    • (2000) Ann Intern Med , vol.132 , Issue.6 , pp. 435-443
    • Olschewski, H.1    Ghofrani, H.A.2    Schmehl, T.3
  • 16
    • 0034702248 scopus 로고    scopus 로고
    • Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue
    • Jun 22
    • Hoeper MM, Schwarze M, Ehlerding S, et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 2000 Jun 22; 342 (25): 1866-70
    • (2000) N Engl J Med , vol.342 , Issue.25 , pp. 1866-1870
    • Hoeper, M.M.1    Schwarze, M.2    Ehlerding, S.3
  • 17
    • 0034626999 scopus 로고    scopus 로고
    • Aerosolized iloprost for primary pulmonary hypertension
    • Nov 9
    • Ewert R, Wensel R, Opitz CF. Aerosolized iloprost for primary pulmonary hypertension [letter]. N Engl J Med 2000 Nov 9; 343 (19): 1421-2
    • (2000) N Engl J Med , vol.343 , Issue.19 , pp. 1421-1422
    • Ewert, R.1    Wensel, R.2    Opitz, C.F.3
  • 18
    • 1842676268 scopus 로고    scopus 로고
    • Preserved long-term efficacy of iloprost inhalation therapy over 2 years in patients with primary pulmonary hypertension
    • abstract no. 1113-52. Feb
    • Opitz CF, Wensel R, Ewert R, et al. Preserved long-term efficacy of iloprost inhalation therapy over 2 years in patients with primary pulmonary hypertension [abstract no. 1113-52]. J Am Coll Cardiol 2000 Feb; 35 (2 Suppl. A): 286A
    • (2000) J Am Coll Cardiol , vol.35 , Issue.2 SUPPL. A
    • Opitz, C.F.1    Wensel, R.2    Ewert, R.3
  • 19
    • 24444439227 scopus 로고    scopus 로고
    • Long-term hemodynamic response in patients with pulmonary hypertension inhaling iloprost (AIR-2 study)
    • abstract no. 3535. Sep
    • Behr J, Nikkho S, Borst M, et al. Long-term hemodynamic response in patients with pulmonary hypertension inhaling iloprost (AIR-2 study) [abstract no. 3535]. Eur Respir J 2003 Sep; 22 Suppl. 45: 562S
    • (2003) Eur Respir J , vol.22 , Issue.45 SUPPL.
    • Behr, J.1    Nikkho, S.2    Borst, M.3
  • 20
    • 0034704997 scopus 로고    scopus 로고
    • Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension
    • May 23
    • Wensel R, Opitz CF, Ewert R, et al. Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension. Circulation 2000 May 23; 101 (20): 2388-92
    • (2000) Circulation , vol.101 , Issue.20 , pp. 2388-2392
    • Wensel, R.1    Opitz, C.F.2    Ewert, R.3
  • 21
    • 0036252810 scopus 로고    scopus 로고
    • Hemodynamic effects of aerosolized iloprost in pulmonary hypertension at rest and during exercise
    • May
    • Blumberg FC, Riegger GA, Pfeifer M. Hemodynamic effects of aerosolized iloprost in pulmonary hypertension at rest and during exercise. Chest 2002 May; 121 (5): 1566-71
    • (2002) Chest , vol.121 , Issue.5 , pp. 1566-1571
    • Blumberg, F.C.1    Riegger, G.A.2    Pfeifer, M.3
  • 22
    • 0037322944 scopus 로고    scopus 로고
    • Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost administered by either infusion or inhalation
    • Feb
    • Opitz CF, Wensel R, Bettmann M, et al. Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost administered by either infusion or inhalation. Eur Heart J 2003 Feb; 24 (4): 356-65
    • (2003) Eur Heart J , vol.24 , Issue.4 , pp. 356-365
    • Opitz, C.F.1    Wensel, R.2    Bettmann, M.3
  • 23
    • 0029993602 scopus 로고    scopus 로고
    • Aerosolized prostacyclin and iloprost in severe pulmonary hypertension
    • May 1
    • Olschewski H, Walmrath D, Schermuly R, et al. Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann Intern Med 1996 May 1; 124 (9): 820-4
    • (1996) Ann Intern Med , vol.124 , Issue.9 , pp. 820-824
    • Olschewski, H.1    Walmrath, D.2    Schermuly, R.3
  • 24
    • 24444434816 scopus 로고    scopus 로고
    • 2) infusion for severe pulmonary hypertension (PH)
    • abstract no. P2836. Aug
    • 2) infusion for severe pulmonary hypertension (PH) [abstract no. P2836]. Eur Respir J 2000 Aug; 16 Suppl. 31: 395S
    • (2000) Eur Respir J , vol.16 , Issue.31 SUPPL.
    • Pepke-Zaba, J.1    Parameshwar, J.2    Eiskjaer, H.3
  • 25
    • 17944376566 scopus 로고    scopus 로고
    • Aerosolised iloprost improves pulmonary haemodynamics in patients with primary pulmonary hypertension receiving continuous epoprostenol treatment
    • Sep
    • Petkov V, Ziesche R, Mosgoeller W, et al. Aerosolised iloprost improves pulmonary haemodynamics in patients with primary pulmonary hypertension receiving continuous epoprostenol treatment. Thorax 2001 Sep; 56 (9): 734-6
    • (2001) Thorax , vol.56 , Issue.9 , pp. 734-736
    • Petkov, V.1    Ziesche, R.2    Mosgoeller, W.3
  • 26
    • 0036852964 scopus 로고    scopus 로고
    • Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension
    • Nov
    • Ghofrani HA, Rose F, Schermuly RT, et al. Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension. Crit Care Med 2002 Nov; 30 (11): 2489-92
    • (2002) Crit Care Med , vol.30 , Issue.11 , pp. 2489-2492
    • Ghofrani, H.A.1    Rose, F.2    Schermuly, R.T.3
  • 27
    • 0037006966 scopus 로고    scopus 로고
    • Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension
    • Apr 2
    • Ghofrani HA, Wiedemann R, Rose F, et al. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med 2002 Apr 2; 136 (7): 515-22
    • (2002) Ann Intern Med , vol.136 , Issue.7 , pp. 515-522
    • Ghofrani, H.A.1    Wiedemann, R.2    Rose, F.3
  • 28
    • 0035845634 scopus 로고    scopus 로고
    • Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension
    • Sep 11
    • Wilkens H, Guth A, König J, et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation 2001 Sep 11; 104 (11): 1218-22
    • (2001) Circulation , vol.104 , Issue.11 , pp. 1218-1222
    • Wilkens, H.1    Guth, A.2    König, J.3
  • 29
    • 24444446127 scopus 로고    scopus 로고
    • Co-application of oxygen improves iloprost inhalation in pulmonary hypertension patients with long-term oxygen therapy
    • abstract no. 2163. Sep
    • Gessler T, Schmehl T, Rose F, et al. Co-application of oxygen improves iloprost inhalation in pulmonary hypertension patients with long-term oxygen therapy [abstract no. 2163]. Eur Respir J Suppl 2001 Sep; 18 Suppl. 33: 324S
    • (2001) Eur Respir J Suppl , vol.18 , Issue.33 SUPPL.
    • Gessler, T.1    Schmehl, T.2    Rose, F.3
  • 30
    • 0036200014 scopus 로고    scopus 로고
    • Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation
    • Mar
    • Beghetti M, Reber G, de MP, et al. Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation. Eur Respir J 2002 Mar; 19 (3): 518-24
    • (2002) Eur Respir J , vol.19 , Issue.3 , pp. 518-524
    • Beghetti, M.1    Reber, G.2    De, M.P.3
  • 31
    • 0036827794 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs
    • Nov
    • Schermuly RT, Schulz A, Ghofrani HA, et al. Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs. J Pharmacol Exp Ther 2002 Nov; 303 (2): 741-5
    • (2002) J Pharmacol Exp Ther , vol.303 , Issue.2 , pp. 741-745
    • Schermuly, R.T.1    Schulz, A.2    Ghofrani, H.A.3
  • 33
    • 0025278205 scopus 로고
    • Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis
    • Mar
    • Nicolini FA, Mehta JL, Nicholds WW, et al. Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. Circulation 1990 Mar; 81 (3): 1115-22
    • (1990) Circulation , vol.81 , Issue.3 , pp. 1115-1122
    • Nicolini, F.A.1    Mehta, J.L.2    Nicholds, W.W.3
  • 34
    • 0026570619 scopus 로고
    • Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue
    • published erratum appears in Circulation 1992 Aug; 86 (2): 698
    • Kerins DM, Roy L, Kunitada S, et al. Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue [published erratum appears in Circulation 1992 Aug; 86 (2): 698]. Circulation 1992; 85 (2): 526-32
    • (1992) Circulation , vol.85 , Issue.2 , pp. 526-532
    • Kerins, D.M.1    Roy, L.2    Kunitada, S.3
  • 35
    • 0025993604 scopus 로고
    • No pharmacokinetic interaction between iloprost and digoxin
    • Penin E, Cheymol G, Bouslama K, et al. No pharmacokinetic interaction between iloprost and digoxin. Eur J Clin Pharmacol 1991; 41 (5): 505-6
    • (1991) Eur J Clin Pharmacol , vol.41 , Issue.5 , pp. 505-506
    • Penin, E.1    Cheymol, G.2    Bouslama, K.3
  • 36
    • 0142121216 scopus 로고    scopus 로고
    • One-year observation of iloprost inhalation therapy in patients with pulmonary hypertension
    • abstract no. 2164. Sep
    • Nikkho S, Seeger W, Baumgartner R, et al. One-year observation of iloprost inhalation therapy in patients with pulmonary hypertension [abstract no. 2164]. Eur Respir J Suppl 2001 Sep; 18 Suppl. 33: 324S
    • (2001) Eur Respir J Suppl , vol.18 , Issue.33 SUPPL.
    • Nikkho, S.1    Seeger, W.2    Baumgartner, R.3
  • 37
    • 0035989826 scopus 로고    scopus 로고
    • Intravenous iloprost for treatment failure of aerosolised iloprost in pulmonary arterial hypertension
    • Aug
    • Hoeper MM, Spiekerkoetter E, Westerkamp V, et al. Intravenous iloprost for treatment failure of aerosolised iloprost in pulmonary arterial hypertension. Eur Respir J 2002 Aug; 20 (2): 339-43
    • (2002) Eur Respir J , vol.20 , Issue.2 , pp. 339-343
    • Hoeper, M.M.1    Spiekerkoetter, E.2    Westerkamp, V.3


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