Activation of the aryl hydrocarbon receptor ahr promotes retinoic acid-induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell transcription factor Oct4

Cancer Research

Volumn 71, Issue 6, 2011, Pages 2371-2380

  Bunaciu, Rodica P ^a   Yen, Andrew ^a  

^a Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CD11B ANTIGEN; CD38 ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN ALDH1; PROTEIN RAF1; RETINOIC ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY BURST; RNA INTERFERENCE; STEM CELL; UPREGULATION;

ANTIGENS, CD11B; ANTIGENS, CD38; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL NUCLEUS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; OCTAMER TRANSCRIPTION FACTOR-3; PHOSPHORYLATION; RAF KINASES; RECEPTORS, ARYL HYDROCARBON; RNA INTERFERENCE; STEM CELLS; TRETINOIN;

EID: 79952753001     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-2299     Document Type: Article

References (45)

1. Hansen LA, Sigman CC, Andreola F, Ross SA, Kelloff GJ, De Luca LM. Retinoids in chemoprevention and differentiation therapy. Carcinogenesis 2000;21:1271-9. (Pubitemid 30455984)
2. Hittelman WN, Liu DD, Kurie JM, Lotan R, Lee JS, Khuri F, et al. Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. J Natl Cancer Inst 2007;99:1603-12.
3. Moriwaki H, Shimizu M, Okuno M, Nishiwaki-Matsushima R. Chemoprevention of liver carcinogenesis with retinoids: basic and clinical aspects. Hepatol Res 2007;37Suppl 2:S299-302.
4. Hall JM, Barhoover MA, Kazmin D, McDonnell DP, Greenlee WF, ThomasRS.Activationof the aryl-hydrocarbonreceptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. Mol Endocrinol 2010;24:359-69.
5. Fan Y, Boivin GP, Knudsen ES, Nebert DW, Xia Y, Puga A. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Res 2010;70:212-20.
6. Harper PA, Giannone JV, Okey AB, Denison MS. In vitro transformation of the human Ah receptor and its binding to a dioxin response element. Mol Pharmacol 1992;42:603-12.
7. Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, Miki H, et al. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 2007;446: 562-6. (Pubitemid 46514731)
8. Ma Q. Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles. Curr Drug Metab 2001;2:149-64.
9. Ohtake F, Fujii-Kuriyama Y, Kato S. AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochem Pharmacol 2009;77: 474-84.
10. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72. (Pubitemid 350138099)
11. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.
12. Utikal J, Maherali N, Kulalert W, Hochedlinger K. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci 2009;122:3502-10.
13. Orkin SH, Wang J, Kim J, Chu J, Rao S, Theunissen TW, et al. The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol. Epub 2008 Nov 6.
14. Kim JB, Greber B, Arauzo-Bravo MJ, Meyer J, Park KI, Zaehres H, et al. Direct reprogramming of human neural stem cells by OCT4. Nature 2009;461:649-3.
15. Soprano DR, Soprano KJ. Pharmacological doses of some synthetic retinoids can modulate both the aryl hydrocarbon receptor and retinoid receptor pathways. J Nutr 2003;133:277S-81S.
16. Ohtake F, Baba A, Fujii-Kuriyama Y, Kato S. Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings. Biochem Biophys Res Commun 2008;370:541-6.
17. Shenefelt RE. Gross congenital malformations. Animal model: treatment of various species with a large dose of vitamin A at known stages in pregnancy. Am J Pathol 1972;66:589-92.
18. Mimura J, Yamashita K, Nakamura K, Morita M, Takagi TN, Nakao K, et al. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 1997;2:645-54.
19. Hayashida Y, Kawamura T, Hori-e R, Yamashita I. Retionic acid and its receptors are required for expression of aryl hydrocarbon receptor mRNA and embryonic development of blood vessel and bone in the medaka fish, Oryzias latipes. Zoolog Sci 2004;21:541-51. (Pubitemid 38836689)
20. Pikarsky E, Sharir H, Ben-Shushan E, Bergman Y. Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. Mol Cell Biol 1994;14:1026-38. (Pubitemid 24036553)
21. Reiterer G, Yen A. Platelet-derived growth factor receptor regulates myeloid and monocytic differentiation of HL-60 cells. Cancer Res 2007;67:7765-72. (Pubitemid 47281370)
22. Reiterer G, Yen A. Inhibition of the Janus kinase family increases extracellular signal-regulated kinase 1/2 phosphorylation and causes endoreduplication. Cancer Res 2006;66:9083-9. (Pubitemid 44521127)
23. Smith J, Bunaciu RP, Reiterer G, Coder D, George T, Asaly M, et al. Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells. Exp Cell Res 2009;315:2241-8.
24. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;1:555-67. (Pubitemid 350056407)
25. Jackson DG, Bell JI. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol 1990;144:2811-5.
26. Zubiaur M, Izquierdo M, Terhorst C, Malavasi F, Sancho J. CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes. J Immunol 1997;159:193-205. (Pubitemid 127493701)
27. Pongratz I, Stromstedt PE, Mason GG, Poellinger L. Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment. J Biol Chem 1991;266:16813-7. (Pubitemid 21907872)
28. Wang J, Yen A. A novel retinoic acid-responsive element regulates retinoic acid-induced BLR1 expression. Mol Cell Biol 2004;24:2423-43. (Pubitemid 38325998)
29. Kang J, Shakya A, Tantin D. Stem cells, stress, metabolism and cancer: a drama in two Octs. Trends Biochem Sci 2009;34:491-9.
30. Hess DA, Meyerrose TE, Wirthlin L, Craft TP, Herrbrich PE, Creer MH, et al. Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity. Blood 2004;104:1648-55. (Pubitemid 39202270)
31. Moreb JS, Gabr A, Vartikar GR, Gowda S, Zucali JR, Mohuczy D. Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde. J Pharmacol Exp Ther 2005;312:339-45. (Pubitemid 40096487)
32. Yen A, Roberson MS, Varvayanis S. Retinoic acid selectively activates the ERK2 but not JNK/SAPK or p38 MAP kinases when inducing myeloid differentiation. In Vitro Cell Devel Biol 1999;35:527-32. (Pubitemid 29530103)
33. Yen A, Roberson MS, Varvayanis S, Lee AT. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res 1998;58:3163-72. (Pubitemid 28335101)
34. Wang J, Yen A. A MAPK-positive feedback mechanism for BLR1 signaling propels retinoic acid-triggered differentiation and cell cycle arrest. J Biol Chem 2008;283:4375-86.
35. Chen S, Operana T, Bonzo J, Nguyen N, Tukey RH. ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem 2005;280:4350-9. (Pubitemid 41741355)
36. Wang S, Ghosh RN, Chellappan SP. Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Mol Cell Biol 1998;18:7487-98. (Pubitemid 28533067)
37. Yen A, Williams M, Platko JD, Der C, Hisaka M. Expression of activated RAF accelerates cell differentiation and RB protein down-regulation but not hypophosphorylation. Eur J Cell Biol 1994;65:103-13. (Pubitemid 24328182)
38. Chen YH, Lavelle D, DeSimone J, Uddin S, Platanias LC, Hankewych M. Growth inhibition of a human myeloma cell line by all-trans retinoic acid is not mediated through downregulation of interleukin-6 receptors but through upregulation of p21(WAF1). Blood 1999;94: 251-9. (Pubitemid 29300156)
39. Rogiers V, Akrawi M, Vercruysse A, Phillips IR, Shephard EA. Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases. Eur J Biochem/FEBS 1995;231:337-43.
40. Schoorlemmer J, van Puijenbroek A, Van Den Eijnden M, Jonk L, Pals C, Kruijer W. Characterization of a negative retinoic acid response element in the murine Oct4 promoter. Mol and Cell Biol 1994;14:1122-36. (Pubitemid 24036563)
41. Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, et al. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 2003;423:545-50. (Pubitemid 36648579)
42. Danel L, Cordier G, Revillard JP, Saez S. Presence of estrogen binding sites and growth-stimulating effect of estradiol in the human myelogenous cell line HL60. Cancer Res 1982;42:4701-5. (Pubitemid 13205976)
43. Kauss MA, Reiterer G, Bunaciu RP, Yen A. Human myeloblastic leukemia cells (HL-60) express a membrane receptor for estrogen that signals and modulates retinoic acid-induced cell differentiation. Exp Cell Res 2008;314:2999-3006.
44. Lee MO, Liu Y, Zhang XK. A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensitivity in transcriptional activation of the lactoferrin gene. Mol Cell Biol 1995;15:4194-207.
45. Hong SK, Yoon S, Moelling C, Arthan D, Park JI. Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem 2009;284:33006-18.