Improvement of acne vulgaris by topical fullerene application: Unique impact on skin care

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 7, Issue 2, 2011, Pages 238-241

  Inui, Shigeki ^a   Aoshima, Hisae ^b   Nishiyama, Aki ^a   Itami, Satoshi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b Vitamin C60 BioResearch Corporation   (Japan)

Author keywords

Acne; Fullerene; Oxidative stress; Sebum

Indexed keywords

ACNE; ACNE VULGARIS; AFTER-TREATMENT; CARBON CAGES; CARBON MOLECULES; FULLERENE APPLICATION; IN-VITRO ASSAYS; INFLAMMATORY DISEASE; NEUTROPHIL INFILTRATION; OXYGEN RADICAL; POLY VINYL PYRROLIDONE; RADICAL SPONGE; REDUCTION RATE; SEBUM; SKIN CARE; THERAPEUTIC AGENTS;

GELS; OXIDATIVE STRESS; OXYGEN; WATER CONTENT;

FULLERENES;

FULLERENE; POVIDONE;

ACNE VULGARIS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; COMEDO; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; IN VITRO STUDY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OPEN STUDY; PAPULE; PUSTULE; SEBUM SECRETION; SKIN CARE; TREATMENT DURATION; TREATMENT RESPONSE;

ACNE VULGARIS; ADMINISTRATION, TOPICAL; ADULT; ANIMALS; CRICETINAE; FEMALE; FREE RADICAL SCAVENGERS; FULLERENES; HUMANS; MALE; OXIDATIVE STRESS; SEBACEOUS GLANDS; SEBUM; SKIN; YOUNG ADULT;

CRICETINAE;

EID: 79952752961     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2010.09.005     Document Type: Article

References (24)

1. Basak P.Y., Gultekin F., Kilinc I. The role of the antioxidative defense system in papulopustular acne. J Dermatol 2001, 28:123-127.
2. Sarici G., Cinar S., Armutcu F., Altinyazar C., Koca R., Tekin N. Oxidative stress in acne vulgaris. J Eur Acad Dermatol Venereol 2010, 24:763-767.
3. Krusic P.J., Wasserman E., Keizer P.N., Morton J.R., Preston K.F. Radical reactions of C60. Science 1991, 254:1183-1185.
4. Dugan L.L., Lovett E.G., Quick K.L., Lotharius J., Lin T.T., O'Malley K.L. Fullerene-based antioxidants and neurodegenerative disorders. Parkinsonism Relat Disord 2001, 7:243-246.
5. Yudoh K., Karasawa R., Masuko K., Kato T. Water-soluble fullerene (C60) inhibits the osteoclast differentiation and bone destruction in arthritis. Int J Nanomed 2009, 4:233-239.
6. Yudoh K., Karasawa R., Masuko K., Kato T. Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritis. Int J Nanomed 2009, 4:217-225.
7. Yudoh K., Shishido K., Murayama H., Yano M., Matsubayashi K., Takada H., et al. Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development. Arthritis Rheum 2007, 56:3307-3318.
8. Gharbi N., Pressac M., Hadchouel M., Szwarc H., Wilson S.R., Moussa F. [60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett 2005, 5:2578-2585.
9. Xiao L., Matsubayashi K., Miwa N. Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues. Arch Dermatol Res 2007, 299:245-257.
10. Rouse J.G., Yang J., Ryman-Rasmussen J.P., Barron A.R., Monteiro-Riviere N.A. Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin. Nano Lett 2007, 7:155-160.
11. Huczko A., Lange H. Fullerenes: experimental evidence for a null risk of skin irritation and allergy. Fullerene Sci Technol 1999, 7:935-939.
12. Taglietti M., Hawkins C.N., Rao J. Novel topical drug delivery systems and their potential use in acne vulgaris. Skin Therapy Lett 2008, 13:6-8.
13. Hayashi N., Akamatsu H., Kawashima M. Establishment of grading criteria for acne severity. J Dermatol 2008, 35:255-260.
14. Kato S., Aoshima H., Saitoh Y., Miwa N. Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue. Basic Clin Pharmacol Toxicol 2009, 104:483-487.
15. Mori T., Takada H., Ito S., Matsubayashi K., Miwa N., Sawaguchi T. Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 2006, 225:48-54.
16. Xiao L., Takada H., Maeda K., Haramoto M., Miwa N. Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes. Biomed Pharmacother 2005, 59:351-358.
17. Kawashima M., Harada S., Loesche C., Miyachi Y. Adapalene gel 0.1% is effective and safe for Japanese patients with acne vulgaris: a randomized, multicenter, investigator-blinded, controlled study. J Dermatol Sci 2008, 49:241-248.
18. Pappas A., Johnsen S., Liu J.C., Eisinger M. Sebum analysis of individuals with and without acne. Dermatoendocrinology 2009, 1:157-161.
19. Mayr-Kanhauser S., Kranke B., Aberer W. Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne. Acta Dermatovenerol Alp Panonica Adriat 2008, 17:139-143.
20. Sedlock D.M., Bailey D.M. Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent. Antimicrob Agents Chemother 1985, 28:786-790.
21. Inui S., Itami S. Perifollicular pigmentation is the first target for topical vitamin C derivative ascorbyl 2-phosphate 6-palmitate (APPS): randomized, single-blinded, placebo-controlled study. J Dermatol 2007, 34:221-223.
22. Schaller M., Loewenstein M., Borelli C., Jacob K., Vogeser M., Burgdorf W.H., et al. Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III. Br J Dermatol 2005, 153:66-71.
23. Borelli C., Merk K., Schaller M., Jacob K., Vogeser M., Weindl G., et al. In vivo porphyrin production by P. acnes in untreated acne patients and its modulation by acne treatment. Acta Derm Venereol 2006, 86:316-319.
24. Aoshima H., Kokubo K., Shirakawa S., Ito M., Yamana S., Oshima T. Antimicrobial activity of fullerenes and their hydroxylated derivatives. Biocontrol Sci 2009, 14:69-72.