Accelerating the discovery of new drug targets with chemical proteomics

IDrugs

Volumn 13, Issue 12, 2010, Pages 862-868

  Cheung, Atwood K ^a   Jain, Rishi K ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Affinity chromatography; cell based assay; chemical genetics; chemical proteomics; drug target; signaling pathway; target identification

Indexed keywords

ADENOSINE KINASE; BETA CATENIN; DASATINIB; DYNAMIN; LDW 639; LDW 643; MELOPHILIN A; MELOPHILIN B; MITOGEN ACTIVATED PROTEIN KINASE; MORPHOLINE DERIVATIVE; PROTEIN INHIBITOR; RAS PROTEIN; TETRAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WNT PROTEIN; XAV 939;

CHRONIC MYELOID LEUKEMIA; DRUG BINDING; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG INDUSTRY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; NONHUMAN; PANCREAS CANCER; PROTEOMICS; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TROPICAL DISEASE; TRYPANOSOMA RHODESIENSE;

ANIMALS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; HUMANS; MOLECULAR TARGETED THERAPY; PHARMACOLOGY; PROTEOMICS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952752198     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (11)

1. Bantscheff M, Scholten A, Heck AJ: Revealing promiscuous drug-target interactions by chemical proteomics. Drug Discov Today (2009) 14(21-22):1021-1029.
2. Bender A, Mikhailov D, Glick M, Scheiber J, Davies JW, Cleaver S, Marshall S, Tallarico JA, Harrington E, Cornella-Taracido I, Jenkins JL: Use of ligand based models for protein domains to predict novel molecular targets and applications to triage affnity chromatography data. J Proteome Res (2009) 8(5):2575-2585.
3. Evans MJ, Cravatt BF: Mechanism-based profling of enzyme families. Chem Rev (2006) 106(8):3279-3301.
4. Fishman MC, Porter JA: Pharmaceuticals: A new grammar for drug discovery. Nature (2005) 437(7058):491-493. (Pubitemid 41613538)
5. Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M et al: Tankyrase inhibition stabilizes Axin and antagonizes Wnt signalling. Nature (2009) 461(7264):614-620.
6. Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT, Faraoni R et al: A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol (2008) 26(1):127-132.
7. Knight ZA, Lin H, Shokat KM: Targeting the cancer kinome through polypharmacology. Nat Rev Cancer (2010) 10(2): 130-137.
8. Rix U, Superti-Furga G: Target profling of small molecules by chemical proteomics. Nat Chem Biol (2009) 5(9):616-624.
9. Sato S, Murata A, Shirakawa T, Uesugi M: Biochemical target isolation for novices: Affnity-based strategies. Chem Biol (2010) 17(6):616-623.
10. Smukste I, Stockwell BR: Advances in chemical genetics. Annu Rev Genomics Hum Genet (2005) 6:261-286. (Pubitemid 41397084)
11. Kitano H: Cancer robustness: Tumour tactics. Nature (2003) 426(6963):125.