MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells

Circulation

Volumn 123, Issue 9, 2011, Pages 999-1009

  Grundmann, Sebastian ^a   Hans, Felix P ^a   Kinniry, Sheena ^a   Heinke, Jennifer ^a   Helbing, Thomas ^a   Bluhm, Franziska ^a   Sluijter, Joost P G ^b   Hoefer, Imo ^b   Pasterkamp, Gerard ^b   Bode, Christoph ^a   Moser, Martin ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

angiogenesis; gene expression; microRNA; oligonucleotide therapeutics; vascular biology

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; OLIGONUCLEOTIDE; RAPAMYCIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTERY OCCLUSION; ARTICLE; BINDING SITE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; HINDLIMB; IN VIVO STUDY; LIMB ISCHEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HEK293 CELLS; HINDLIMB; HUMANS; ISCHEMIA; MICE; MICE, INBRED C57BL; MICRORNAS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOVASCULARIZATION, PATHOLOGIC; TOR SERINE-THREONINE KINASES;

EID: 79952739991     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.000323     Document Type: Article

References (27)

1. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6:389-395. (Pubitemid 30208155)
2. Lee CW, Stabile E, Kinnaird T, Shou M, Devaney JM, Epstein SE, Burnett MS. Temporal patterns of gene expression after acute hindlimb ischemia in mice: insights into the genomic program for collateral vessel development. J Am Coll Cardiol. 2004;43:474-482. (Pubitemid 38167711)
3. Ambros V. The functions of animal microRNAs. Nature. 2004;431: 350-355. (Pubitemid 39265675)
4. Small EM, Frost RJ, Olson EN. MicroRNAs add a new dimension to cardiovascular disease. Circulation. 2010;121:1022-1032.
5. Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G. Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005;280:9330-9335. (Pubitemid 40409626)
6. Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, Thomas-Tikhonenko A. Augmentation of tumor angiogenesis by a myc-activated microRNA cluster. Nat Genet. 2006;38:1060-1065. (Pubitemid 44325933)
7. Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher AM, Dimmeler S. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 2009;324:1710-1713.
8. Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M. Silencing of microRNAs in vivo with "antagomirs." Nature. 2005;438:685-689.
9. Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J. 2002;16:771-780. (Pubitemid 34615125)
10. Wang FZ, Weber F, Croce C, Liu CG, Liao X, Pellett PE. Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication. J Virol. 2008;82:9065-9074.
11. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G. MiRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 2002;16: 720-728. (Pubitemid 34274041)
12. Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008;68:425-433. (Pubitemid 351380068)
13. Varnholt H, Drebber U, Schulze F, Wedemeyer I, Schirmacher P, Dienes HP, Odenthal M. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology. 2008;47: 1223-1232. (Pubitemid 351547908)
14. Nam EJ, Yoon H, Kim SW, Kim H, Kim YT, Kim JH, Kim JW, Kim S. MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res. 2008;14:2690-2695.
15. Sucharov C, Bristow MR, Port JD. MiRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol. 2008;45: 185-192.
16. Henson BJ, Bhattacharjee S, O'Dee DM, Feingold E, Gollin SM. Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009;48: 569-582.
17. Shi W, Alajez NM, Bastianutto C, Hui AB, Mocanu JD, Ito E, Busson P, Lo KW, Ng R, Waldron J, O'Sullivan B, Liu FF. Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer. Int J Cancer. 2010;126:2036-2048.
18. Van Solingen C, Seghers L, Bijkerk R, Duijs JM, Roeten MK, Van Oeveren-Rietdijk AM, Baelde HJ, Monge M, Vos JB, de Boer HC, Quax PH, Rabelink TJ, Van Zonneveld AJ. Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. J Cell Mol Med. 2009;13:1577-1585.
19. Grundmann S, Hoefer I, Ulusans S, Van Royen N, Schirmer SH, Ozaki CK, Bode C, Piek JJ, Buschmann I. Anti-tumor necrosis factor-{alpha} therapies attenuate adaptive arteriogenesis in the rabbit. Am J Physiol Heart Circ Physiol. 2005;289:H1497-H1505. (Pubitemid 41368991)
20. Grundmann S, Van Royen N, Pasterkamp G, Gonzalez N, Tijsma EJ, Piek JJ, Hoefer IE. A new intra-arterial delivery platform for pro-arteriogenic compounds to stimulate collateral artery growth via transforming growth factor-beta1 release. J Am Coll Cardiol. 2007;50:351-358. (Pubitemid 47058887)
21. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 2008;79: 581-588.
22. Boettger T, Beetz N, Kostin S, Schneider J, Kruger M, Hein L, Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the miR143/145 gene cluster. J Clin Invest. 2009;119:2634-2647.
23. Schaper W, Scholz D. Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol. 2003;23:1143-1151. (Pubitemid 36871267)
24. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S. MicroRNA-21 contributes to myocardial disease by stimulating map kinase signalling in fibroblasts. Nature. 2008;456: 980-984.
25. Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R. Hypoxia- induced endothelial proliferation requires both mTORC1 and mTORC2. Circ Res. 2007;100:79-87. (Pubitemid 46066776)
26. Yap TA, Carden CP, Kaye SB. Beyond chemotherapy: targeted therapies in ovarian cancer. Nat Rev Cancer. 2009;9:167-181.
27. Shaw RJ, Cantley LC. RAS, Pi(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441:424-430. (Pubitemid 44050136)