Advances in perfusion magnetic resonance imaging in Alzheimer's disease

Alzheimer's and Dementia

Volumn 7, Issue 2, 2011, Pages 185-196

  Chen, Wei ^a,b   Song, Xiaowei ^a,c   Beyea, Steven ^a,c   D'Arcy, Ryan ^a,c   Zhang, Yunting ^b   Rockwood, Kenneth ^c,d  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c DALHOUSIE UNIVERSITY   (Canada)

^d QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Alzheimer's disease; Arterial spin labeling; Cerebral blood flow; Cerebral blood volume; Dynamic susceptibility contrast; Magnetic resonance imaging; Mild cognitive impairment; Perfusion

Indexed keywords

ALZHEIMER DISEASE; BRAIN PERFUSION; DIAGNOSTIC PROCEDURE; FOLLOW UP; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PERFUSION WEIGHTED IMAGING; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TEMPORAL LOBE;

ALZHEIMER DISEASE; BRAIN; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY;

EID: 79952738017     PISSN: 15525260     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jalz.2010.04.004     Document Type: Review

References (88)

1. Alzheimer's Association. 2009 Alzheimer's disease facts and figures. Alzheimers Dement 2009;5:234-70.
2. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59.
3. Mattsson N, Blennow K, Zetterberg H. CSF biomarkers: pinpointing Alzheimer pathogenesis. Ann NY Acad Sci 2009;1180:28-35.
4. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-6. (Pubitemid 34790756)
5. Rocchi A, Orsucci D, Tognoni G, Ceravolo R, Siciliano G. The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects. Curr Alzheimer Res 2009;6:224-37.
6. Hachinski V, Munoz DG. Cerebrovascular pathology in Alzheimer's disease: cause, effect or epiphenomenon? Ann NY Acad Sci 1997;826:1-6. (Pubitemid 27478026)
7. Morović S, Jurasić MJ, Martinić Popović I, Serić V, Lisak M, Demarin V. Vascular characteristics of patients with dementia. J Neurol Sci 2009;283:41-3.
8. Viswanathan A, Rocca WA, Tzourio C. Vascular risk factors and dementia: how to move forward? Neurology 2009;72:368-74.
9. de la Torre JC. Cerebrovascular and cardiovascular pathology in Alzheimer's disease. Int Rev Neurobiol 2009;84:35-48.
10. Skoog I, Gustafson D. Hypertension, hypertension-clustering factors and Alzheimer's disease. Neurol Res 2003;25:675-80. (Pubitemid 37087613)
11. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6:734-46. (Pubitemid 47058377)
12. Scheltens P. Imaging in Alzheimer's disease. Dialogues Clin Neurosci 2009;11:191-9.
13. Smith CD. Neuroimaging through the course of Alzheimer's disease. J Alzheimers Dis 2010;19:273-90.
14. Zimny A, Sasiadek M, Leszek J, Czarnecka A, Trypka E, Kiejna A. Does perfusion CT enable differentiating Alzheimer's disease from vascular dementia and mixed dementia? A preliminary report. J Neurol Sci 2007;257:114-20. (Pubitemid 46856514)
15. Stefani A, Sancesario G, Pierantozzi M, Leone G, Galati S, Hainsworth AH, et al. CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer's and mixed dementia. J Neurol Sci 2009;283:109-15.
16. Wintermark M, Sesay M, Barbier E, Borbély K, Dillon WP, Eastwood JD, et al. Comparative overview of brain perfusion imaging techniques. Stroke 2005;36:e83-99.
17. Holman BL, Tumeh SS. Single-photon emission computed tomography (SPECT). Applications and potential. JAMA 1990;263:561-4.
18. DeKosky ST, Shih WJ, Schmitt FA, Coupal J, Kirkpatrick C. Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease: correlation with cognitive severity. Alzheimer Dis Assoc Disord 1990;4:14-23. (Pubitemid 20311746)
19. Ito H, Kanno I, Fukuda H. Human cerebral circulation: positron emission tomography studies. Ann Nucl Med 2005;19:65-74. (Pubitemid 40745687)
20. Alsop DC, Detre JA, Grossman M. Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging. Ann Neurol 2000;47:93-100. (Pubitemid 30033655)
21. Detre JA, Wang J, Wang Z, Rao H. Arterial spin-labeled perfusion MRI in basic and clinical neuroscience. Curr Opin Neurol 2009;22:348-55.
22. Pollock JM, Tan H, Kraft RA, Whitlow CT, Burdette JH, Maldjian JA. Arterial spin-labeled MR perfusion imaging: clinical applications. Magn Reson Imaging Clin N Am 2009;17:315-38.
23. Kim SG. Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping. Magn Reson Med 1995;34:293-301.
24. Jahng GH, Zhu XP, Matson GB, Weiner MW, Schuff N. Improved perfusion weighted MRI by a novel double inversion with proximal labeling of both tagged and control acquisitions. Magn Reson Med 2003;49:307-14. (Pubitemid 36159868)
25. Tanabe JL, Yongbi M, Branch C, Hrabe J, Johnson G, Helpern JA. MR perfusion imaging in human brain using the UNFAIR technique. Uninverted flow-sensitive alternating inversion recovery. J Magn Reson Imaging 1999;9:761-7. (Pubitemid 29266388)
26. Liu TT, Brown GG. Measurement of cerebral perfusion with arterial spin labeling: part 1. Methods. J Int Neuropsychol Soc 2007;13:517-25. (Pubitemid 47307492)
27. Aguirre GK, Detre JA, Zarahn E, Alsop DC. Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage 2002;15:488-500. (Pubitemid 34852517)
28. Tjandra T, Brooks JC, Figueiredo P, Wise R, Matthews PM, Tracey I. Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial design. Neuroimage 2005;27:393-401. (Pubitemid 41074841)
29. Matsuda H. Role of neuroimaging in Alzheimer's disease, with emphasis on brain perfusion SPECT. J Nucl Med 2007;48:1289-300. (Pubitemid 47242794)
30. Bradley KM, O'Sullivan VT, Soper ND, Nagy Z, King EM, Smith AD, et al. Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease. Brain 2002;125:1772-81.
31. Kogure D, Matsuda H, Ohnishi T, Asada T, Uno M, Kunihiro T, et al. Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT. J Nucl Med 2000;41:1155-62. (Pubitemid 30463997)
32. Hirao K, Ohnishi T, Hirata Y, Yamashita F, Mori T, Moriguchi Y, et al. The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT. Neuroimage 2005;28:1014-21. (Pubitemid 41713635)
33. Wang H, Golob E, Bert A, Nie K, Chu Y, Dick MB, et al. Alterations in regional brain volume and individual MRI-guided perfusion in normal control, stable mild cognitive impairment, and MCI-AD converter. J Geriatr Psychiatry Neurol 2009;22:35-45.
34. Guedj E, Barbeau EJ, Didic M, Felician O, de Laforte C, Ranjeva JP, et al. Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: deafferentation and functional compensation? Eur J Nucl Med Mol Imaging 2009;36:1101-12.
35. Hirao K, Ohnishi T, Matsuda H, Nemoto K, Hirata Y, Yamashita F, et al. Functional interactions between entorhinal cortex and posterior cingulate cortex at the very early stage of Alzheimer's disease using brain perfusion single-photon emission computed tomography. Nucl Med Commun 2006;27:151-6. (Pubitemid 44391824)
36. O'Brien JT. Role of imaging techniques in the diagnosis of dementia. Br J Radiol 2007;80:S71-7.
37. Pasquier J, Michel BF, Brenot-Rossi I, Hassan-Sebbag N, Sauvan R, Gastaut JL. Value of (99m)Tc-ECD SPET for the diagnosis of dementia with Lewy bodies. Eur J Nucl Med Mol Imaging 2002;29:1342-8. (Pubitemid 44392216)
38. Kemp PM, Hoffmann SA, Holmes C, Bolt L, Ward T, Holmes RB, et al. The contribution of statistical parametric mapping in the assessment of precuneal and medial temporal lobe perfusion by 99mTc-HMPAO SPECT in mild Alzheimer's and Lewy body dementia. Nucl Med Commun 2005;26:1099-106. (Pubitemid 41677600)
39. Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhl DE. Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol 2001;50:358-65. (Pubitemid 32848738)
40. Waragai M, Mizumura S, Yamada T, Matsuda H. Differentiation of early-stage Alzheimer's disease from other types of dementia using brain perfusion single photon emission computed tomography with easy Z-score imaging system analysis. Dement Geriatr Cogn Disord 2008;26:547-55.
41. Ishii K, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H, Mori E. Paradoxical hippocampus perfusion in mild-to-moderate Alzheimer's disease. J Nucl Med 1998;39:293-8. (Pubitemid 28114520)
42. Ishii K, Sasaki M, Yamaji S, Sakamoto S, Kitagaki H, Mori E. Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography. Eur J Nucl Med 1997;24:670-3. (Pubitemid 27299749)
43. Jagust WJ, Eberling JL, Reed BR, Mathis CA, Budinger TF. Clinical studies of cerebral blood flow in Alzheimer's disease. Ann NY Acad Sci 1997;826:254-62. (Pubitemid 27478047)
44. Tohgi H, Yonezawa H, Takahashi S, Sato N, Kato E, Kudo M, et al. Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter changes. Neuroradiology 1998;40:131-7. (Pubitemid 28438820)
45. Jeong Y, Cho SS, Park JM, Kang SJ, Lee JS, Kang E, et al. 18F-FDG PET findings in frontotemporal dementia: an SPM analysis of 29 patients. J Nucl Med 2005;46:233-9. (Pubitemid 43073429)
46. Harris GJ, Lewis RF, Satlin A, English CD, Scott TM, Yurgelun-Todd DA, Renshaw PF. Dynamic susceptibility contrast MRI of regional cerebral blood volume in Alzheimer's disease. Am J Psychiatry 1996;153:721-4. (Pubitemid 26133631)
47. Maas LC, Harris GJ, Satlin A, English CD, Lewis RF, Renshaw PF. Regional cerebral blood volume measured by dynamic susceptibility contrast MR imaging in Alzheimer's disease: a principal components analysis. J Magn Reson Imaging 1997;7:215-9. (Pubitemid 28365663)
48. Harris GJ, Lewis RF, Satlin A, English CD, Scott TM, Yurgelun-Todd DA, et al. Dynamic susceptibility contrast MR imaging of regional cerebral blood volume in Alzheimer disease: a promising alternative to nuclear medicine. AJNR Am J Neuroradiol 1998;19:1727-32. (Pubitemid 30413765)
49. Bozzao A, Floris R, Baviera ME, Apruzzese A, Simonetti G. Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load. AJNR Am J Neuroradiol 2001;22:1030-6. (Pubitemid 32587412)
50. Luckhaus C, Flüb MO, Wittsack HJ, Grass-Kapanke B, Jänner M, Khalili-Amiri R, et al. Detection of changed regional cerebral blood flow in mild cognitive impairment and early Alzheimer's dementia by perfusion-weighted magnetic resonance imaging. Neuroimage 2008;40:495-503.
51. Kubota T, Ushijima Y, Yamada K, Okuyama C, Kizu O, Nishimura T. Diagnosis of Alzheimer's disease using brain perfusion SPECT and MR imaging: which modality achieves better diagnostic accuracy? Eur J Nucl Med Mol Imaging 2005;32:414-21.
52. Cavallin L, Danielsson R, Oksengard AR, Wahlund LO, Julin P, Frank A, et al. Can dynamic susceptibility contrast magnetic resonance imaging replace single-photon emission computed tomography in the diagnosis of patients with Alzheimer's disease? A pilot study. Acta Radiol 2006;47:977-85. (Pubitemid 44673505)
53. Yoshiura T, Mihara F, Kuwabara Y, Ogomori K, Kaneko K, Tanaka A, et al. MR relative cerebral blood flow mapping of Alzheimer disease: correlation with Tc-99m HMPAO SPECT. Acad Radiol 2002;9:1383-7. (Pubitemid 36331012)
54. Mattia D, Babiloni F, Romigi A, Cincotti F, Bianchi L, Sperli F, et al. Quantitative EEG and dynamic susceptibility contrast MRI in Alzheimer's disease: a correlative study. Clin Neurophysiol 2003;114:1210-6. (Pubitemid 36776818)
55. Olazarán J, Alvarez-Linera J, de Santiago R, Escribano J, Benito-León J, Morales JM. Regional correlations between MR imaging perfusion and SPECT in Alzheimer's disease. Neurologia 2005;20:240-4. (Pubitemid 40979025)
56. Sandson TA, O'Connor M, Sperling RA, Edelman RR, Warach S. Non-invasive perfusion MRI in Alzheimer's disease: a preliminary report. Neurology 1996;47:1339-42. (Pubitemid 26374914)
57. Johnson NA, Jahng GH, Weiner MW, Miller BL, Chui HC, Jagust WJ, et al. Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology 2005;234:851-9. (Pubitemid 40250829)
58. Xu G, Antuono PG, Jones J, Xu Y, Wu G, Ward D, et al. Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects. Neurology 2007;69:1650-6. (Pubitemid 350287120)
59. Asllani I, Habeck C, Scarmeas N, Borogovac A, Brown TR, Stern Y. Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's disease. J Cereb Blood Flow Metab 2008;28:725-36. (Pubitemid 351432785)
60. Alsop DC, Casement M, de Bazelaire C, Fong T, Press DZ. Hippocampal hyperperfusion in Alzheimer's disease. Neuroimage 2008;42:1267-74.
61. Yoshiura T, Hiwatashi A, Yamashita K, Ohyagi Y, Monji A, Takayama Y, et al. Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease. AJNR Am J Neuroradiol 2009;30:1388-93.
62. Schuff N, Matsumoto S, Kmiecik J, Studholme C, Du A, Ezekiel F, et al. Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimers Dement 2009;5:454-62.
63. Dai W, Lopez OL, Carmichael OT, Becker JT, Kuller LH, Gach HM. Mild cognitive impairment and Alzheimer disease: patterns of altered cerebral blood flow at MR imaging. Radiology 2009;250:856-66.
64. Du AT, Jahng GH, Hayasaka S, Kramer JH, Rosen HJ, Gorno-Tempini ML, et al. Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI. Neurology 2006;67:1215-20. (Pubitemid 44563830)
65. Yoshiura T, Hiwatashi A, Noguchi T, Yamashita K, Ohyagi Y, Monji A, et al. Arterial spin labelling at 3-T MR imaging for detection of individuals with Alzheimer's disease. Eur Radiol 2009;19:2819-25.
66. Fleisher AS, Podraza KM, Bangen KJ, Taylor C, Sherzai A, Sidhar K, et al. Cerebral perfusion and oxygenation differences in Alzheimer's disease risk. Neurobiol Aging 2009;30:1737-48.
67. Xu G, Rowley HA, Wu G, Alsop DC, Shankaranarayanan A, Dowling M, et al. Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with (15)O-water PET in elderly subjects at risk for Alzheimer's disease. NMR Biomed 2010;23:286-93.
68. LaFrance ND, Parker JR, Smith MD, McGhan WF, Renshaw PF, Harris GJ, Weaver M. Dynamic susceptibility contrast MR imaging for the evaluation of probable Alzheimer disease: a cost-effectiveness analysis. Acad Radiol 1998;5(Suppl 1):S231-5.
69. Krishnan S, Talley BD, Slavin MJ, Doraiswamy PM, Petrella JR. Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research. Neuroimaging Clin N Am 2005;15:853-68. (Pubitemid 43162383)
70. Ishii K, Minoshima S. PET is better than perfusion SPECT for early diagnosis of Alzheimer's disease - for. Eur J Nucl Med Mol Imaging 2005;32:1463-5.
71. Pupi A, Nobili FM. PET is better than perfusion SPECT for early diagnosis of Alzheimer's disease - against. Eur J Nucl Med Mol Imaging 2005;32:1466-72.
72. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
73. Hämäläinen A, Pihlajamäki M, Tanila H, Hänninen T, Niskanen E, Tervo S, et al. Increased fMRI responses during encoding in mild cognitive impairment. Neurobiol Aging 2007;28:1889-903. (Pubitemid 47539695)
74. Kircher TT, Weis S, Freymann K, Erb M, Jessen F, Grodd W, et al. Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding. J Neurol Neurosurg Psychiatry 2007;78:812-8. (Pubitemid 47204583)
75. Sperling R. Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease. Ann NY Acad Sci 2007;1097:146-55. (Pubitemid 47084886)
76. Grady CL, McIntosh AR, Beig S, Keightley ML, Burian H, Black SE. Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J Neurosci 2003;23:986-93. (Pubitemid 36206190)
77. Gould RL, Arroyo B, Brown RG, Owen AM, Bullmore ET, Howard RJ. Brain mechanisms of successful compensation during learning in Alzheimer disease. Neurology 2006;67:1011-7. (Pubitemid 44454595)
78. Han D, Bangen KJ, Bondi MW. Functional magnetic resonance imaging of compensatory neural recruitment in aging and risk for Alzheimer's disease: review and recommendation. Dement Geriatr Cogn Disord 2009;27:1-10.
79. Kessler RM. Imaging methods for evaluating brain function in man. Neurobiol Aging 2003;24(Suppl 1):S21-35. discussion S37-9.
80. Wang J, Alsop DC, Li L, Listerud J, Gonzalez-At JB, Schnall MD, Detre JA. Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 tesla. Magn Reson Med 2002;48:242-54. (Pubitemid 34809412)
81. Golay X, Petersen ET. Arterial spin labeling: benefits and pitfalls of high magnetic field. Neuroimaging Clin N Am 2006;16:259-68. (Pubitemid 43775486)
82. Yongbi MN, Fera F, Yang Y, Frank JA, Duyn JH. Pulsed arterial spin labeling: comparison of multisection baseline and functional MRimaging perfusion signal at 1.5 and 3.0T: initial results in six subjects. Radiology 2002;222:569-75. (Pubitemid 34106137)
83. Talagala SL, Ye FQ, Ledden PJ, Chesnick S. Whole-brain 3D perfusion MRI at 3.0 T using CASL with a separate labeling coil. Magn Reson Med 2004;52:131-40. (Pubitemid 39295265)
84. Wang J, Zhang Y, Wolf RL, Roc AC, Alsop DC, Detre JA. Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study. Radiology 2005;235:218-28. (Pubitemid 40432258)
85. Jahng GH, Weiner MW, Schuff N. Improved arterial spin labeling method: applications for measurements of cerebral blood flow in human brain at high magnetic field MRI. Med Phys 2007;34:4519-25. (Pubitemid 350029674)
86. Mitnitski A, Rockwood K. Transitions in cognitive test scores over 5 and 10 years in elderly people: evidence for a model of age-related deficit accumulation. BMC Geriatr 2008;8:3.
87. Wu WC, Wong EC. Feasibility of velocity selective arterial spin labeling in functional MRI. J Cereb Blood Flow Metab 2007;27:831-8. (Pubitemid 46474617)
88. Wong EC, Cronin M, Wu WC, Inglis B, Frank LR, Liu TT. Velocityselective arterial spin labeling. Magn Reson Med 2006;55:1334-41.