Brain mechanisms of successful compensation during learning in Alzheimer disease

Neurology

Volumn 67, Issue 6, 2006, Pages 1011-1017

  Gould, R L ^a   Arroyo, B ^b   Brown, R G ^a   Owen, A M ^c   Bullmore, E T ^d   Howard, R J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^c MRC COGNITION AND BRAIN SCIENCES UNIT   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LEARNING; MALE; NEUROPATHOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN MAPPING; CASE-CONTROL STUDIES; COMPENSATION AND REDRESS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LEARNING; MAGNETIC RESONANCE IMAGING; MALE; NEURONAL PLASTICITY; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PSYCHOMOTOR PERFORMANCE; SPACE PERCEPTION;

EID: 33749010323     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000237534.31734.1b     Document Type: Article

References (30)

1. Buckner RL. Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron 2004;44:195-208.
2. Becker JT, Mintun MA, Aleva K, Wiseman MB, Nichols T, DeKosky ST. Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease. Neurology 1996;46:692-700.
3. Woodard JL, Grafton ST, Votaw JR, Green RC, Dobraski ME, Hoffman JM. Compensatory recruitment of neural resources during overt rehearsal of word lists in Alzheimer's disease. Neuropsychology 1998;12:491-504.
4. Bäckman L, Andersson J, Nyberg L, Winblad B, Nordberg A, Almkvist O. Brain regions associated with episodic retrieval in normal aging and Alzheimer's disease. Neurology 1999;52:1861-1870.
5. Horwitz B, McIntosh AR, Haxby JV, et al. Network analysis of PET-mapped visual pathways in Alzheimer type dementia. Neuroreport 1995;6:2287-2292.
6. Grady CL, McIntosh AR, Beig S, Keightley ML, Burian H, Black SE. Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J Neurosci 2003;23:986-993.
7. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer disease - report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
8. Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR. Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease. Dement Geriatr Cogn Disord 2004;17:42-48.
9. Fowler KS, Saling MM, Conway EL, Semple JM, Louis WJ. Paired associate performance in the early detection of DAT. J Int Neuropsychol Soc 2002;8:58-71.
10. de Jager CA, Milwain E, Budge M. Early detection of isolated memory deficits in the elderly: the need for more sensitive neuropsychological tests. Psychol Med 2002;32:483-491.
11. Sahakian BJ, Morris RG, Evenden JL, et al. A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain 1988;111:695-718.
12. Swainson R, Hodges JR, Galton CJ, et al. Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks. Dement Geriatr Cogn Disord 2001;12:265-280.
13. Gould RL, Brown RG, Owen AM, Bullmore ET, Williams SC, Howard RJ. Functional neuroanatomy of successful paired associate learning in Alzheimer's disease. Am J Psychiatry 2005;162:2049-2060.
14. Talairach J, Tournoux P. A co-planar stereotactic atlas of the human brain. Stuttgart, Germany: Thieme, 1988.
15. Wellcome Department of Neurology, London. Available at: http://www.fil.ion.ucl.ac.uk/spm/. Accessed April 18, 2006.
16. Friston KJ, Holmes AP, Worsely KJ, Poline JB, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 1995;2:189-210.
17. Mattis S. DRS-2. Dementia Rating Scale-2. Lutz, FL: Psychological Assessment Resources, 2001.
18. Duncan J, Owen AM. Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends Neurosci 2000;23:475-483.
19. Cabeza R, Nyberg L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. J Cogn Neurosci 2000;12:1-47.
20. Callicott JH, Mattay VS, Bertolino A, et al. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex 1999;9:20-26.
21. Bertolino A, Adler C, Callicott J, et al. Effects of ketamine on working memory circuitry as studied by whole brain fMRI. Biol Psychiatry 1997;41:64S.
22. Fletcher PC, McKenna PJ, Frith CD, Grasby PM, Friston KJ, Dolan RJ. Brain activations in schizophrenia during a graded memory task studies with functional neuroimaging. Arch Gen Psychiatry 1998;55:1001-1008.
23. Rombouts SA, Barkhof F, Van Meel CS, Scheltens P. Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2002;73:665-671.
24. Saykin AJ, Wishart HA, Rabin LA, et al. Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. Brain 2004;127:1574-1583.
25. Furey ML, Pietrini P, Haxby JV. Cholinergic enhancement and increased selectivity of perceptual processing during working memory. Science 2000;290:2315-2319.
26. Sperling R, Greve D, Dale A, et al. Functional MRI detection of pharmacologically induced memory impairment. Proc Natl Acad Sci USA 2002;99:455-460.
27. Wang QS, Zhou JN. Retrieval and encoding of episodic memory in normal aging and patients with mild cognitive impairment. Brain Res 2002;924:113-115.
28. Buschke H, Sliwinski MJ, Kuslansky G, Lipton RB. Diagnosis of early dementia by the Double Memory Test: encoding specificity improves diagnostic sensitivity and specificity. Neurology 1997;48:989-997.
29. Carlesimo GA, Mauri M, Graceffa AM, et al. Memory performances in young, elderly, and very old healthy individuals versus patients with Alzheimer's disease: evidence for discontinuity between normal and pathological aging. J Clin Exp Neuropsychol 1998;20:14-29.
30. Deweer B, Pillon B, Pochon JB, Dubois B. Is the HM story only a 'remote memory'? Some facts about hippocampus and memory in humans. Behav Brain Res 2001;127:209-224.