Identification of critical process variables affecting particle size following precipitation using a supercritical fluid

Pharmaceutical Development and Technology

Volumn 11, Issue 2, 2006, Pages 187-194

  Sacha, Gregory ^a   Schmitt, William ^b   Nail, Steven ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Crystallization; Precipitation; Supercritical antisolvent; Supercritical fluid

Indexed keywords

CARBON DIOXIDE; METHYLPREDNISOLONE ACETATE; ORGANIC SOLVENT; TETRAHYDROFURAN;

ANALYTICAL PARAMETERS; ARTICLE; DISPERSION; DRUG SOLUBILITY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PARTICLE SIZE; PRECIPITATION; PRESSURE; PRIORITY JOURNAL; SUPERCRITICAL FLUID; TECHNIQUE;

CARBON DIOXIDE; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; FACTOR ANALYSIS, STATISTICAL; IMAGE PROCESSING, COMPUTER-ASSISTED; LIGHT; METHYLPREDNISOLONE; PARTICLE SIZE; PRESSURE; SCATTERING, RADIATION; SOLUBILITY; SOLUTIONS; SOLVENTS; TEMPERATURE;

EID: 33745059340     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450600691237     Document Type: Article

References (6)

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