One-pot synthesis of pyrimidines via cyclocondensation of β-bromovinyl aldehydes with amidine hydrochlorides

Helvetica Chimica Acta

Volumn 94, Issue 3, 2011, Pages 487-490

  Yan, Shengjiao ^a   Tang, Yajuan ^a   Yu, Fuchao ^a   Lin, Jun ^a  

^a YUNNAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOCONDENSATION; ONE-POT SYNTHESIS;

AROMATIC COMPOUNDS;

ALDEHYDES;

2 (4 CHLOROPHENYL) 4 (4 METHYLPHENYL)PYRIMIDINE; 2 (4 CHLOROPHENYL) 5,6,7,8 TETRAHYDROQUINAZOLINE; 2,4 BIS(4 CHLOROPHENYL)PYRIMIDINE; 2,4 BIS(4 METHYLPHENYL)PYRIMIDINE; 4 (4 CHLOROPHENYL) 2 (4 METHYLPHENYL)PYRIMIDINE; 4 (4 CHLOROPHENYL) 2 [4 (TRIFLUOROMETHYL)PHENYL]PYRIMIDINE; 4 (4 CHLOROPHENYL) 2 PHENYLPYRIMIDINE; 4 (4 METHYLPHENYL) 2 (PYRIDIN 4 YL)PYRIMIDINE; 4 (4 METHYLPHENYL) 2 [4 (TRIFLUOROMETHYL)PHENYL]PYRIMIDINE; 4 (TRIFLUOROMETHYL)BENZAMIDINE; 4 PHENYL 2 [4 (TRIFLUOROMETHYL)PHENYL]PYRIMIDINE; 5,6,7,8 TETRAHYDRO 2 (4 METHYLPHENYL)QUINAZOLINE; 5,6,7,8 TETRAHYDRO 2 (PYRIDIN 4 YL)QUINAZOLINE; ALDEHYDE DERIVATIVE; AMIDINE; BETA BROMOVINYL ALDEHYDE; DIOXANE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; CYCLOCONDENSATION; DRUG STRUCTURE; MASS SPECTROMETRY; ONE POT SYNTHESIS; PRIORITY JOURNAL;

EID: 79952719370     PISSN: 0018019X     EISSN: 15222675     Source Type: Journal    
DOI: 10.1002/hlca.201000264     Document Type: Article

References (9)

1. S. Yan, C. Huang, C. Su, Y. Ni, J. Lin, J. Comb. Chem. 2010, 12, 91;
2. S.-J. Yan, Y.-F. Niu, R. Huang, J. Lin, Synlett 2009, 2821.
3. M. Seki, H. Kubota, K. Matsumoto, A. Kinumaki, T. Date, K. Okamura, J. Org. Chem. 1993, 58, 6354.
4. K. Burdeska, H. Fuhrer, G. Kabas, A. E. Siegrist, Helv. Chim. Acta 1981, 64, 113.
5. A. C. Spivey, R. Srikaran, C. M. Diaper, D. J. Turner, Org. Biomol. Chem. 2003, 1, 1638.
6. N. Nishiwaki, K. Ymashita, M. Azuma, T. Adachi, M. Tamura, M. Ariga, Synthesis 2004, 1996.
7. M. G. Barthakur, M. Borthakur, P. Devi, C. J. Saikia, A. Saikia, U. Bora, A. Chetia, R. C. Boruah, Synlett 2007, 223.
8. M. Bhattacharya, J. Indian Chem. Soc. 1927, 4, 156.
9. R. M. Coates, P. D. Senter, W. R. Baker, J. Org. Chem. 1982, 47, 3597.