Traceless solid phase synthesis of 2-substituted pyrimidines using an 'off-the-shelf' chlorogermane-functionalised resin

Organic and Biomolecular Chemistry

Volumn 1, Issue 10, 2003, Pages 1638-1640

  Spivey, Alan C ^a,b   Srikaran, Ratnasothy ^a   Diaper, Christopher M ^a   Turner, David J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE COMPOUNDS; CONDENSATION; INFRARED SPECTROSCOPY; MICROANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC COMPOUNDS; RESINS; STRUCTURE (COMPOSITION); SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

AMIDINE HYDROCHLORIDE; CHLOROGERMANE-FUNCTIONALIZED RESIN; PYRIMIDINE; SOLID PHASE SYNTHESIS;

NITROGEN COMPOUNDS;

EID: 0141974909     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b303064d     Document Type: Article

References (19)

1. M. Leibl, J. Comb. Chem., 1999, 1, 3.
2. R. A. Haughton, Annu. Rev. Pharmacol. Toxicol., 2000, 40, 273.
3. E. Ward and P. Bernasconi, Nat. Biotechnol., 1999, 17, 618.
4. C. A. Briehn and P. Bäuerle, Chem. Commun., 2002, 1015.
5. A. C. Comedy and S. E. Gibson, Angew. Chem., Int. Ed., 2001, 40, 1012.
6. P. Blaney, R. Grigg and V. Sridharan, Chem. Rev., 2002, 102, 2607.
7. A. C. Spivey, C. M. Diaper, H. Adams and A. Rudge, J. Org. Chem., 2000, 65, 5253.
8. A. C. Spivey, D. J. Turner, M. L. Turner and S. Yeates, Org. Lett., 2002, 4, 1899.
9. C. Eaborn, J. Organomet. Chem., 1975, 100, 43.
10. A. C. Spivey, C. M. Diaper and A. Rudge, Chem. Commun., 1999, 835.
11. M. J. Plunkett and J. A. Ellman, J. Org. Chem., 1997, 62, 2885.
12. R. W. Bott, C. Eaborn and T. W. Swaddle, J. Chem. Soc., 1963, 2342.
13. S. Itô and T. Tsunoda, Pure Appl. Chem., 1999, 71, 1053.
14. P. M. S. Chauhan, S. K. Srivastava and K. Sanjay, Comb. Chem. High Throughput Screening, 2001, 4, 35.
15. W. Klose and K. Schwarz, J. Heterocycl. Chem., 1982, 19, 1165.
16. (a) L. Mosti, G. Menozzi and P. Schenone, J. Heterocycl. Chem., 1983, 20, 649
17. (b) A. Tanaka, Y. Motoyama and H. Takasugi, Chem. Pharm. Bull., 1994, 42, 1828.
18. R. Paul, W. A. Hallett, J. W. Hanifin, M. F. Reich, B. D. Johnson, R. H. Lenhard, J. P. Dusza, S. S. Kerwar, Y. Lin, W. C. Pickett, C. M. Seifert, L. W. Torley, M. E. Tarrant and S. Wrenn, J. Med. Chem., 1993, 36, 2716.
19. J.-C. Marie, J. Marrot and R. Nabet, Bull. Chim. Soc. Fr., 1981, 429 and references therein.