Traditional Chinese formula, lubricating gut pill, stimulates cAMP-dependent Cl- secretion across rat distal colonic mucosa

Journal of Ethnopharmacology

Volumn 134, Issue 2, 2011, Pages 406-413

  Wu, Dazheng ^a,b,c   Zhou, Jiyan ^a,b   Wang, Xinhong ^a   Cui, Bo ^a   An, Rui ^a   Shi, Hailian ^a,b   Yuan, Jianye ^a,b   Hu, Zhibi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai Key Laboratory of Complex Prescription   (China)

^c LINYI PEOPLE'S HOSPITAL   (China)

Author keywords

Chloride secretion; Colonic mucosa; Cyclic adenosine monophosphate; Ion currents; Prostaglandin; Protein kinase A; Short circuit current

Indexed keywords

CHINESE DRUG; CHLORIDE CHANNEL; CHROMANOL 293B; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GASTROINTESTINAL AGENT; LUBRICATING GUT PILL; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NYSTATIN; POTASSIUM CHANNEL; PROSTANOID RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CHINESE MEDICINE; CHLORIDE CONDUCTANCE; CHLORIDE CURRENT; CHLORIDE TRANSPORT; COLON MUCOSA; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC POTENTIAL; ELECTRIC RESISTANCE; ION CURRENT; MALE; NONHUMAN; POTASSIUM CURRENT; PROTEIN SECRETION; RAT; SHORT CIRCUIT CURRENT; SIGNAL TRANSDUCTION;

ANGIOSPERMS; ANIMALS; ANIONS; BENZOIC ACIDS; CELL MEMBRANE; CHLORIDE CHANNELS; CHLORIDES; COLON; CONSTIPATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUGS, CHINESE HERBAL; INTESTINAL MUCOSA; ION TRANSPORT; MALE; NYSTATIN; PERMEABILITY; PHYTOTHERAPY; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, WISTAR; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; THIAZOLIDINES;

RATTUS;

EID: 79952709145     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.12.031     Document Type: Article

References (29)

1. Barrett, K.E., Keely, S.J., 2000. Chloride secretion by the intestinal epithelium:molecular basis and regulatory aspects. Annual Review of Physiology 62, 535-572. (Pubitemid 30618274)
2. - secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology 137, 976-985.
3. Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72, 248-254.
4. Deachapunya, C., Poonyachoti, S., Thongsaard, W., Krishnamra, N., 2005. Barakol extracted from Cassia siamea stimulates chloride secretion in rat colon. The Journal of Pharmacology and Experimental Therapeutics 314, 732-737. (Pubitemid 41043856)
5. Dey, I., Lejeune, M., Chadee, K., 2006. Prostaglandin E2 receptor distribution and function in the gastrointestinal tract. British Journal of Pharmacology 149, 611-623. (Pubitemid 44748054)
6. - secretion in rat distal colon by genistein, a protein tyrosine kinase inhibitor. European Journal of Pharmacology 299, 161-170.
7. Field, M., 2003. Intestinal ion transport and the pathophysiology of diarrhea. The Journal of Clinical Investigation 111, 931-943. (Pubitemid 36397466)
8. Greger, R., 2000. Role of CFTR in the colon. Annual Review of Physiology 62, 467-491.
9. - secretion. Comparative Biochemistry and Physiology Part A Physiology 118, 271-275.
10. Greger, R., Mall, M., Bleich, M., Ecke, D., Warth, R., Riedemann, N., Kunzelmann, K., 1996. Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance regulator. Journal of Molecular Medicine 74, 527-534. (Pubitemid 26306795)
11. Halm, D.R., Halm, S.T., 2001. Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways. American Journal of Physiology Gastrointestinal and Liver Physiology 281, G984-G996.
12. Illek, B., Fischer, H., Machen, T.E., 1996. Alternate stimulation of apical CFTR by genistein in epithelia. American Journal of Physiology 270, C265-C275.
13. + channel KVLQT1. The Journal of Membrane Biology 179, 155-164.
14. Kunzelmann, K., Mall, M., 2002. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiological Reviews 82, 245-289. (Pubitemid 34654220)
15. + channels in human normal and cystic fibrosis airway epithelia. Pediatric Research 53, 608-618.
16. + channel involvement in forskolin-activated chloride secretion in human colon. Journal of Physiology 519, 251-260.
17. Morteau, O., Morham, S.G., Sellon, R., Dieleman, L.A., Langenbach, R., Smithies, O., Sartor, R.B., 2000. Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. Journal of Clinical Investigation 105, 469-478. (Pubitemid 30127247)
18. Schroeder, B.C., Waldegger, S., Fehr, S., Bleich, M., Warth, R., Greger, R., Jentsch, T.J., 2000. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403, 196-199. (Pubitemid 30050962)
19. Schultheiss, G., Hennig, B., Diener, M., 2008. Sites of action of hydrogen peroxide on ion transport across rat distal colon. British Journal of Pharmacology 154, 991-1000. (Pubitemid 351915064)
20. Schultheiss, G., Lan Kocks, S., Diener, M., 2005. Stimulation of colonic anion secretion by monochloramine: action sites. Pflugers Archiv 449, 553-563. (Pubitemid 40543650)
21. Takafuji, V., Cosme, R., Lublin, D., Lynch, K., Roche, J.K., 2000. Prostanoid receptors in intestinal epithelium: selective expression, function, and change with inflammation. Prostaglandins Leukotrienes and Essential Fatty Acids 63, 223-235.
22. von Hahn, T., Thiele, I., Zingaro, L., Hamm, K., Garcia-Alzamora, M., Kottgen, M., Bleich, M., Warth, R., 2001. Characterisation of the rat SK4/IK1 K(+) channel. Cellular Physiology and Biochemistry 11, 219-230.
23. + channel (rSK4) of colonic crypts. Pflugers Archiv 438, 437-444.
24. + conductance of rat colonic crypt base cells. Pflugers Archiv 432, 81-88.
25. Wegmann, M., Kampen, A., Weber, S., Seyberth, H.W., Kockerling, A., 2000. Effect of hydroxyeicosatetraenoic acids on furosemide-sensitive chloride secretion in rat distal colon. The Journal of Pharmacology and Experimental Therapeutics 295, 133-138.
26. Wu, D., Hu, Z., 2008. Rutaecarpine induces chloride secretion across rat isolated distal colon. The Journal of Pharmacology and Experimental Therapeutics 325, 256-266. (Pubitemid 351439168)
27. - secretion across distal colonic epithelium. Journal of Ethnopharmacology 130, 347-353.
28. Wu, D.Z., Yuan, J.Y., Shi, H.L., Hu, Z.B., 2008. Palmatine, a protoberberine alkaloid, inhibits both Ca(2+)- and cAMP-activated Cl(-) secretion in isolated rat distal colon. British Journal of Pharmacology 153, 1203-1213. (Pubitemid 351415504)
29. Wu, L., Li, X., Li, Y., Wang, L., Tang, Y., Xue, M., 2009. Proliferative inhibition of danxiongfang and its active ingredients on rat vascular smooth muscle cell and protective effect on the VSMC damage induced by hydrogen peroxide. Journal of Ethnopharmacology 126, 197-206.