Synthesis and evaluation of fluorinated aporphines: Potential positron emission tomography ligands for D2 receptors

ACS Medicinal Chemistry Letters

Volumn 2, Issue 3, 2011, Pages 189-194

  Sromek, Anna W ^a   Si, Yu Gui ^a   Zhang, Tangzhi ^a   George, Susan R ^b   Seeman, Philip ^b   Neumeyer, John L ^a  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aporphine; D2 agonist; dopamine receptors; neurological disorders; positron emission tomography

Indexed keywords

APORPHINE DERIVATIVE; CATECHOL; DOPAMINE 2 RECEPTOR;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 79952659857     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml1001689     Document Type: Article

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