Radiosynthesis and ex vivo evaluation of (R)-(-)-2-chloro-N-[1-11C-propyl]n-propylnorapomorphine

Nuclear Medicine and Biology

Volumn 37, Issue 1, 2010, Pages 35-40

  Palner, Mikael ^a,b   McCormick, Patrick ^c   Gillings, Nic ^b,d   Begtrup, Mikael ^a,b   Wilson, Alan A ^c   Knudsen, Gitte M ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Center for Integrated Molecular Brain Imaging   (Denmark)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^d Rigshospitalet   (Denmark)

Author keywords

2 Cl 11C ( ) NPA; 11C ( ) NPA; Agonist; Amphetamine; Apomorphine; D2; D3; Dopamine; P glycoprotein; PET; Radioligand

Indexed keywords

(1 PROPYL) N PROPYLNORAPOMORPHINE C 11; 2 CHLORO N (1 PROPYL) N PROPYLNORAPOMORPHINE C 11; CARBON 11; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; GLYCOPROTEIN P; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BRAIN LEVEL; DRUG METABOLISM; DRUG PURITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; EX VIVO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; REDUCTION;

ANIMALS; APOMORPHINE; HYDROPHOBICITY; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SUBSTRATE SPECIFICITY; TISSUE DISTRIBUTION;

EID: 72449130868     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.08.005     Document Type: Article

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