Eukaryotic elongation factor eEF1A1 promotes and Ser300 mutants of eEF1A1 inhibit transition through the S and G2/M phases of the cell cycle;Ökaryotik uzama faktörü eEF1A1 G2/M geçişini destekler ve eEF1A1S'nin Ser300 mutantı engeller

Journal of Cell and Molecular Biology

Volumn 8, Issue 2, 2010, Pages 125-130

  Lin, Kah Wai ^a   Souchelnytskyi, Serhiy ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Breast cancer; Cell cycle; Elongation factor; Phosphorylation; Proliferation

Indexed keywords

ELONGATION FACTOR 1ALPHA; EUKARYOTIC ELONGATION FACTOR 1ALPHA 1; UNCLASSIFIED DRUG;

ARTICLE; BREAST EPITHELIUM; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL TRANSFORMATION; HUMAN; HUMAN CELL; MUTANT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS;

EUKARYOTA;

EID: 79952653328     PISSN: 13033546     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ and Lee JM. Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nat Genet. 31: 301-5, 2002.
2. Bektas M, Nurten R, Gurel Z, Sayers Z, Bermek E. Interactions of eukaryotic elongation factor 2 with actin: a possible link between protein synthetic machinery and cytoskeleton. FEBS Lett. 356: 89-93, 1994.
3. Cao H, Zhu Q, Huang J, Li B, Zhang S, Yao W and Zhang Y. Regulation and functional role of eEF1A2 in pancreatic carcinoma. Biochem Biophys Res Commun. 380: 11-6, 2009.
4. Castro J, Heiden T, Wang N and Tribukait B. Preparation of cell nuclei from fresh tissues for high-quality DNA flow cytometry. Cytometry. 14: 793-804, 1993.
5. Condeelis J. Elongation factor 1 alpha, translation and the cytoskeleton. Trends Biochem Sci. 20: 169-70, 1995.
6. Coppard NJ, Clark BF and Cramer F. Methylation of elongation factor 1 alpha in mouse 3T3B and 3T3B/SV40 cells. FEBS Lett. 164: 330-4, 1983.
7. Edmonds BT, Wyckoff J, Yeung YG, Wang Y, Stanley ER, Jones J, Segall J and Condeelis J. Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma. J Cell Sci. 109 (Pt 11): 2705-14, 1996.
8. Feng XH and Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol. 21: 659-93, 2005.
9. Fukuda M and Ohashi M. Aphidicolin inhibits cell growth by accumulation of G2 cells. Cell Biol Int Rep. 7: 579-85, 1983.
10. Grassi G, Scaggiante B, Farra R, Dapas B, Agostini F, Baiz D, Rosso N and Tiribelli C. The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade. Biochimie. 89: 1544-52, 2007.
11. Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K and Kaibuchi K. Elongation factor-1 alpha is a novel substrate of rho-associated kinase. Biochem Biophys Res Commun. 278: 72-8, 2000.
12. Kato MV, Sato H, Nagayoshi M and Ikawa Y. Upregulation of the elongation factor-1alpha gene by p53 in association with death of an erythroleukemic cell line. Blood. 90: 1373-8, 1997.
13. Knudsen SM, Frydenberg J, Clark BF and Leffers H. Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. Eur J Biochem. 215: 549-54, 1993.
14. Lamberti A, Caraglia M, Longo O, Marra M, Abbruzzese A and Arcari P. The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article. Amino Acids. 26: 443-8, 2004.
15. Lee S, Francoeur AM, Liu S and Wang E. Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family. J Biol Chem. 267: 24064-8, 1992.
16. Lin K, Yakymovych I, Jia M, Yakymovych M and Souchelnytskyi S. Phosphorylation of eukaryotic elongation factor eEF1A at Ser300 by type I transforming growth factor-b-receptor results in inhibition of mRNA translation. Current Biol. doi:10.1016/j.cub.2010.08.017, 2010.
17. Liu H, Ding J, Chen F, Fan B, Gao N, Yang Z and Qi L. Increased expression of elongation factor-1alpha is significantly correlated with poor prognosis of human prostate cancer. Scand J Urol Nephrol. 44: 277-83, 2010.
18. Massague J. A very private TGF-beta receptor embrace. Mol Cell. 29: 149-50, 2008
19. Miyazono K, Suzuki H and Imamura T. Regulation of TGF-beta signaling and its roles in progression of tumors. Cancer Sci. 94: 230-4, 2003.
20. Moldave K. Eukaryotic protein synthesis. Annu Rev Biochem. 54: 1109-49, 1985
21. Pavey S, Russell T and Gabrielli B. G2 phase cell cycle arrest in human skin following UV irradiation. Oncogene. 20: 6103-10, 2001.
22. Peters HI, Chang YW and Traugh JA. Phosphorylation of elongation factor 1 (EF-1) by protein kinase C stimulates GDP/GTP-exchange activity. Eur J Biochem. 234: 550-6, 1995.
23. Van Goietsenoven G, Hutton J, Becker JP, Lallemand B, Robert F, Lefranc F, Pirker C, Vandenbussche G, Van Antwerpen P, Evidente A, Berger W, Prevost M, Pelletier J, Kiss R, Goss Kinzy T, Kornienko A and Mathieu V. Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. Faseb J. 2010; doi: 10.1096/fj.10-162263.
24. Zhang J, Guo H, Mi Z, Gao C, Bhattacharya S, Li J and Kuo PC. EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. Exp Cell Res. 315: 304-12, 2009.