Hepcidin and iron species distribution inside the first-trimester human gestational sac

Molecular Human Reproduction

Volumn 17, Issue 4, 2011, Pages 227-232

  Evans, Patricia ^a   Cindrova Davies, Tereza ^b   Muttukrishna, Shanthi ^c   Burton, Graham J ^b   Porter, John ^a   Jauniaux, Eric ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Amniotic fluid; Coelomic fluid; Hepcidin; Placenta; Yolk sac

Indexed keywords

HEPCIDIN; IRON;

ADULT; AMNION FLUID; ARTICLE; BLOOD SAMPLING; FETUS; FETUS BLOOD; FIRST TRIMESTER PREGNANCY; GESTATIONAL SAC; HUMAN; IMMUNOHISTOCHEMISTRY; IRON BLOOD LEVEL; IRON TRANSPORT; MATERNAL SERUM; NORMAL HUMAN; PLACENTA; PREGNANCY; PRIORITY JOURNAL; SYNCYTIOTROPHOBLAST; YOLK SAC;

AMNIOTIC FLUID; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD CHEMICAL ANALYSIS; FEMALE; GESTATIONAL SAC; HUMANS; IMMUNOHISTOCHEMISTRY; IRON; PREGNANCY; PREGNANCY TRIMESTER, FIRST;

EID: 79952607965     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gaq101     Document Type: Article

References (34)

1. Brown PJ, Johnson PM, Ogbimi AO, Tappin JA. Characterization and localization of human placental ferritin. Biochem J 1979;182:763-769.
2. Burton GJ, Hempstock J, Jauniaux E. Oxygen, early embryonic metabolism and radical mediated embryopathies. Reprod Biomed Online 2003; 6:84-96.
3. Casanueva E, Viteri FE. Iron and oxidative stress in pregnancy. J Nutr 2003; 133:1700s-1708s.
4. Ervasti M, Sankilampi U, Luukkonen S, Heinonen S, Punnonen K. Maternal pro-hepcidin at term correlates with cord blood pro-hepcidin at birth. Eur J Obstet Gynecol Reprod Biol 2009;147:161-165.
5. Evans RW, Williams J. The electrophoresis of transferrins in urea/polyacrylamide gels. Biochem J 1980;189:541-546.
6. Evans RW, Rafique R, Zarea A, Rapisarda C, Cammack R, Evans PJ, Porter JB, Hider RC. Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera. J Biol Inorg Chem 2008; 13:57-74.
7. Fryer AA, Jones P, Strange R, Hume R, Bell JE. Plasma protein levels in normal human fetuses: 13 to 41 weeks gestation. Br J Obstet Gynecol 1993;100:850-855.
8. Ganz T. Hepcidin in iron metabolism. Curr Opin Hematol 2004; 11:251-254.
9. Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med 2010;62:13.1-13.14.
10. Gitlin D, Biasucci A. Development of G, A, M, 1c/, C'1 esterase inhibitor, ceruloplasmin, transferrin, hemopexin, haptoglobin, fibrinogen, plasminogen, 1-antitrypsin, orosomucoid, -lipoprotein, 2-macroglubulin, and prealbumin in the human conceptus. J Clin Invest 1969;48:1433-1446.
11. Gitlin D, Kumate J, Urrusti J, Morales C. The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus. J Clin Invest 1964;43:1938-1951.
12. Gosriwatana I, Loreal O, Lu S, Brissot P, Porter J, Hider RC. Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin. Anal Biochem 1999;273:212-220.
13. Gulbis B, Jauniaux E, Decuyper J, Thiry P, Jurkovic D, Campbell S. Distribution of iron and iron-binding proteins in first trimester human pregnancies. Obstet Gynecol 1994;84:289-293.
14. Gulbis B, Jauniaux E, Cotton F, Stordeur P. Protein and enzyme pattern in fluid cavities of the first trimester gestational sac: relevance to the absorptive role of the secondary yolk sac. Mol Hum Reprod 1998; 4:857-882.
15. Halliwell B, Gutteridge JM. Free Radicals in Biology and Medicine, 4th edn. Oxford, UK: Oxford University Press, 2007.
16. Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992;119:598-620.
17. Hugman A. Hepcidin: an important new regulator of iron homeostasis. Clin Lab Haematol 2006;28:75-83.
18. Jauniaux E, Gulbis B. Fluid compartments of the embryonic environment. Hum Reprod Update 2000;6:268-278.
19. Jauniaux E, Jurkovic D, Gulbis B, Gervy C, Ooms HA, Campbell S. Biochemical composition of coelomic fluid in early human pregnancy. Obstet Gynecol 1991;78:1124-1128.
20. Jauniaux E, Gulbis B, Schandene L, Collette J, Hustin J. Distribution of interleukin-6 in maternal and embryonic tissues during the first trimester. Mol Hum Reprod 1996;2:239-243.
21. Jauniaux E, Gulbis B, Burton GJ. The human first trimester gestational sac limits rather than facilities oxygen transfer to the foetus: a review. Placenta 2003;24:S86-S93.
22. Jauniaux E, Cindrova-Davies T, Johns T, Dunster C, Hempstock J, Kelly F, Burton GJ. Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac. J Clin Endocrinol Metab 2004;89:1452-1458.
23. Jauniaux E, Johns J, Gulbis B, Spasic-Boskovic O, Burton GJ. Transfer of folic acid inside the first trimester gestational sac and the effect of maternal Smoking. Am J Obstet Gynecol 2007;197:58-e1-58e6.2.
24. Knisely AS, Grady RW, Kramer EE, Jones RL. Cytoferrin, materno-fetal iron transport and neonatal hemochromatosis. Am J Clin Pathol 1989; 92:755-759.
25. McArdle HJ, Danzeisen R, Fosset C, Gambling L. The role of the placenta in iron transfer from mother to fetus and the relationship between iron status and fetal outcome. Biometals 2003;16:161-167.
26. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306:2090-2093.
27. Okuyama AT, Tawada T, Furuya H, Villee C. The role of transferrin and ferritin in the fetal-maternal-placental unit. Am J Obst Gynecol 1985; 152:344-350.
28. Radisky DC, Kaplan J. Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts. Biochem J 1998; 336:201-205.
29. Rhoades R, Pflanzer R. Human Physiology, 2nd edn. Philadelphia: Saunders, 1992.
30. Seligman PA, Schleicher RB, Allen RH. Isolation and characterization of the transferrin receptor from human placenta. J Biol Chem 1979; 254:9943-9946.
31. Singh S, Hider RC, Porter JB. A direct method for quantification of Non-transferrin bound iron (NTBI). Anal Biochem 1990; 186:320-323.
32. Wada HG, Hass PE, Sussman HH. Transferrin receptor in human placental brush border membranes. J Biol Chem 1979;254: 12629-12635.
33. Weinberg ED. Can iron be teratogenic? Biometals 2010;23:181-184.
34. Zhang AS, Enns CA. Molecular mechanisms of normal iron homeostasis. Hematology Am Soc Hematol Educ Program 2009;2:207-214.