메뉴 건너뛰기




Volumn 18, Issue 2, 2011, Pages 91-97

Molecular Regulation of Phosphate Metabolism by Fibroblast Growth Factor-23-Klotho System

Author keywords

Calcium; FGF23; Klotho; NaPi; PTH; Vitamin D

Indexed keywords

DENTIN MATRIX PROTEIN 1; FIBROBLAST GROWTH FACTOR 23; KERATINOCYTE GROWTH FACTOR; KLOTHO PROTEIN; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; SECRETED FRIZZLED RELATED PROTEIN 4;

EID: 79952597190     PISSN: 15485595     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ackd.2010.11.007     Document Type: Review
Times cited : (28)

References (72)
  • 1
    • 0030570745 scopus 로고    scopus 로고
    • Inorganic phosphate is transported into mitochondria in the absence of ATP biosynthesis: an in vivo 31P NMR study in the human skeletal muscle
    • Iotti S., Lodi R., Gottardi G., Zaniol P., Barbiroli B. Inorganic phosphate is transported into mitochondria in the absence of ATP biosynthesis: an in vivo 31P NMR study in the human skeletal muscle. Biochem Biophys Res Commun 1996, 225:191-194.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 191-194
    • Iotti, S.1    Lodi, R.2    Gottardi, G.3    Zaniol, P.4    Barbiroli, B.5
  • 2
    • 0026610207 scopus 로고
    • A 31P NMR study of mitochondrial inorganic phosphate visibility: effects of Ca2+, Mn2+, and the pH gradient
    • Hutson S.M., Williams G.D., Berkich D.A., LaNoue K.F., Briggs R.W. A 31P NMR study of mitochondrial inorganic phosphate visibility: effects of Ca2+, Mn2+, and the pH gradient. Biochemistry 1992, 31:1322-1330.
    • (1992) Biochemistry , vol.31 , pp. 1322-1330
    • Hutson, S.M.1    Williams, G.D.2    Berkich, D.A.3    LaNoue, K.F.4    Briggs, R.W.5
  • 3
    • 25444528711 scopus 로고    scopus 로고
    • Hypophosphatemia: an update on its etiology and treatment
    • Gaasbeek A., Meinders A.E. Hypophosphatemia: an update on its etiology and treatment. Am J Med 2005, 118:1094-1101.
    • (2005) Am J Med , vol.118 , pp. 1094-1101
    • Gaasbeek, A.1    Meinders, A.E.2
  • 4
    • 77954775628 scopus 로고    scopus 로고
    • Long-term control of parathyroid hormone and calcium-phosphate metabolism after parathyroidectomy in children with chronic kidney disease
    • Schaefer B., Schlosser K., Wuhl E., et al. Long-term control of parathyroid hormone and calcium-phosphate metabolism after parathyroidectomy in children with chronic kidney disease. Nephrol Dial Transplant 2010, 25:2590-2595.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 2590-2595
    • Schaefer, B.1    Schlosser, K.2    Wuhl, E.3
  • 5
    • 54149083620 scopus 로고    scopus 로고
    • Bone mineral metabolism and its relationship to kidney disease in a residential care home population: a cross-sectional study
    • Carter J.L., O'Riordan S.E., Eaglestone G.L., Delaney M.P., Lamb E.J. Bone mineral metabolism and its relationship to kidney disease in a residential care home population: a cross-sectional study. Nephrol Dial Transplant 2008, 23:3554-3565.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3554-3565
    • Carter, J.L.1    O'Riordan, S.E.2    Eaglestone, G.L.3    Delaney, M.P.4    Lamb, E.J.5
  • 6
    • 78650641156 scopus 로고    scopus 로고
    • Osteocalcin: a pivotal mediator or an innocent bystander in energy metabolism? Nephrol Dial Transplant
    • In press. doi:. doi:10.1093/ndt/gfq1721
    • Razzaque MS. Osteocalcin: a pivotal mediator or an innocent bystander in energy metabolism? Nephrol Dial Transplant. In press. doi:. doi:10.1093/ndt/gfq1721.
    • Razzaque, M.S.1
  • 7
    • 0036415142 scopus 로고    scopus 로고
    • Renal osteodystrophy and secondary hyperparathyroidism
    • Fukagawa M., Kazama J.J., Kurokawa K. Renal osteodystrophy and secondary hyperparathyroidism. Nephrol Dial Transplant 2002, 17(suppl 10):2-5.
    • (2002) Nephrol Dial Transplant , vol.17 , Issue.SUPPL. 10 , pp. 2-5
    • Fukagawa, M.1    Kazama, J.J.2    Kurokawa, K.3
  • 8
    • 77955082747 scopus 로고    scopus 로고
    • Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
    • Fulzele K., Riddle R.C., Digirolamo D.J., et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 2010, 142:309-319.
    • (2010) Cell , vol.142 , pp. 309-319
    • Fulzele, K.1    Riddle, R.C.2    Digirolamo, D.J.3
  • 9
    • 27944491618 scopus 로고    scopus 로고
    • "Phosphatonins" and the regulation of phosphorus homeostasis
    • Berndt T.J., Schiavi S., Kumar R. "Phosphatonins" and the regulation of phosphorus homeostasis. Am J Physiol Renal Physiol 2005, 289:F1170-F1182.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Berndt, T.J.1    Schiavi, S.2    Kumar, R.3
  • 10
    • 23444447617 scopus 로고
    • Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia
    • Cai Q., Hodgson S.F., Kao P.C., et al. Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. N Engl J Med 1994, 330:1645-1649.
    • (1994) N Engl J Med , vol.330 , pp. 1645-1649
    • Cai, Q.1    Hodgson, S.F.2    Kao, P.C.3
  • 11
    • 0033847087 scopus 로고    scopus 로고
    • Tumor-induced osteomalacia and the regulation of phosphate homeostasis
    • Kumar R. Tumor-induced osteomalacia and the regulation of phosphate homeostasis. Bone 2000, 27:333-338.
    • (2000) Bone , vol.27 , pp. 333-338
    • Kumar, R.1
  • 12
    • 0033763097 scopus 로고    scopus 로고
    • Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
    • White K.E., Evans W.E., O'Rlordan J.L.H., et al. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 2000, 26:345-348.
    • (2000) Nat Genet , vol.26 , pp. 345-348
    • White, K.E.1    Evans, W.E.2    O'Rlordan, J.L.H.3
  • 13
    • 0036095905 scopus 로고    scopus 로고
    • Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism
    • De Beur S.M., Finnegan R.B., Vassiliadis J., et al. Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism. J Bone Miner Res 2002, 17:1102-1110.
    • (2002) J Bone Miner Res , vol.17 , pp. 1102-1110
    • De Beur, S.M.1    Finnegan, R.B.2    Vassiliadis, J.3
  • 14
    • 70350348267 scopus 로고    scopus 로고
    • The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis
    • Razzaque M.S. The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis. Nat Rev Endocrinol 2009, 5:611-619.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 611-619
    • Razzaque, M.S.1
  • 15
    • 85047693146 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent
    • Berndt T., Craig T.A., Bowe A.E., et al. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 2003, 112:785-794.
    • (2003) J Clin Invest , vol.112 , pp. 785-794
    • Berndt, T.1    Craig, T.A.2    Bowe, A.E.3
  • 16
    • 34250649644 scopus 로고    scopus 로고
    • The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis
    • Razzaque M.S., Lanske B. The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis. J Endocrinol 2007, 194:1-10.
    • (2007) J Endocrinol , vol.194 , pp. 1-10
    • Razzaque, M.S.1    Lanske, B.2
  • 17
    • 10744226781 scopus 로고    scopus 로고
    • MEPE has the properties of an osteoblastic phosphatonin and minhibin
    • Rowe P.S., Kumagai Y., Gutierrez G., et al. MEPE has the properties of an osteoblastic phosphatonin and minhibin. Bone 2004, 34:303-319.
    • (2004) Bone , vol.34 , pp. 303-319
    • Rowe, P.S.1    Kumagai, Y.2    Gutierrez, G.3
  • 18
    • 9144248333 scopus 로고    scopus 로고
    • FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa
    • Shimada T., Urakawa I., Yamazaki Y., et al. FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem Biophys Res Commun 2004, 314:409-414.
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 409-414
    • Shimada, T.1    Urakawa, I.2    Yamazaki, Y.3
  • 19
    • 33748090908 scopus 로고    scopus 로고
    • Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism
    • Kuro-o M. Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr Opin Nephrol Hypertens 2006, 15:437-441.
    • (2006) Curr Opin Nephrol Hypertens , vol.15 , pp. 437-441
    • Kuro-o, M.1
  • 20
    • 57449105957 scopus 로고    scopus 로고
    • Endocrine functions of bone in mineral metabolism regulation
    • Quarles L.D. Endocrine functions of bone in mineral metabolism regulation. J Clin Invest 2008, 118:3820-3828.
    • (2008) J Clin Invest , vol.118 , pp. 3820-3828
    • Quarles, L.D.1
  • 21
    • 2142746439 scopus 로고    scopus 로고
    • FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    • Shimada T., Hasegawa H., Yamazaki Y., et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 2004, 19:429-435.
    • (2004) J Bone Miner Res , vol.19 , pp. 429-435
    • Shimada, T.1    Hasegawa, H.2    Yamazaki, Y.3
  • 22
    • 33646367420 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    • Liu S., Tang W., Zhou J., et al. Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol 2006, 17:1305-1315.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1305-1315
    • Liu, S.1    Tang, W.2    Zhou, J.3
  • 23
    • 49649118142 scopus 로고    scopus 로고
    • Endocrine FGFs and Klothos: emerging concepts
    • Kuro-o M. Endocrine FGFs and Klothos: emerging concepts. Trends Endocrinol Metab 2008, 19:239-245.
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 239-245
    • Kuro-o, M.1
  • 24
    • 67349229781 scopus 로고    scopus 로고
    • Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase
    • Ohnishi M., Nakatani T., Lanske B., Razzaque M.S. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 2009, 75:1166-1172.
    • (2009) Kidney Int , vol.75 , pp. 1166-1172
    • Ohnishi, M.1    Nakatani, T.2    Lanske, B.3    Razzaque, M.S.4
  • 25
    • 79952700577 scopus 로고    scopus 로고
    • The dualistic role of vitamin D in vascular calcifications
    • In press. doi:. doi:10.1038/ki.2010.1432
    • Razzaque MS. The dualistic role of vitamin D in vascular calcifications. Kidney Int. In press. doi:. doi:10.1038/ki.2010.1432.
    • Kidney Int.
    • Razzaque, M.S.1
  • 26
    • 0034703619 scopus 로고    scopus 로고
    • Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain
    • Yamashita T., Yoshioka M., Itoh N. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun 2000, 277:494-498.
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 494-498
    • Yamashita, T.1    Yoshioka, M.2    Itoh, N.3
  • 27
    • 38149134409 scopus 로고    scopus 로고
    • Functional evolutionary history of the mouse Fgf gene family
    • Itoh N., Ornitz D.M. Functional evolutionary history of the mouse Fgf gene family. Dev Dyn 2008, 237:18-27.
    • (2008) Dev Dyn , vol.237 , pp. 18-27
    • Itoh, N.1    Ornitz, D.M.2
  • 28
    • 33646578195 scopus 로고    scopus 로고
    • Regulation of fibroblast growth factor-23 signaling by klotho
    • Kurosu H., Ogawa Y., Miyoshi M., et al. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 2006, 281:6120-6123.
    • (2006) J Biol Chem , vol.281 , pp. 6120-6123
    • Kurosu, H.1    Ogawa, Y.2    Miyoshi, M.3
  • 29
    • 59649091992 scopus 로고    scopus 로고
    • In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis
    • Nakatani T., Sarraj B., Ohnishi M., et al. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. FASEB J 2009, 23:433-441.
    • (2009) FASEB J , vol.23 , pp. 433-441
    • Nakatani, T.1    Sarraj, B.2    Ohnishi, M.3
  • 30
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M., Matsumura Y., Aizawa H., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1    Matsumura, Y.2    Aizawa, H.3
  • 31
    • 2342610541 scopus 로고    scopus 로고
    • Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane
    • 565:143-147.
    • Imura A, Iwano A, Tohyama O, et al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett. 565:143-147.
    • FEBS Lett
    • Imura, A.1    Iwano, A.2    Tohyama, O.3
  • 32
    • 1642416884 scopus 로고    scopus 로고
    • Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
    • Shimada T., Kakitani M., Yamazaki Y., et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 2004, 113:561-568.
    • (2004) J Clin Invest , vol.113 , pp. 561-568
    • Shimada, T.1    Kakitani, M.2    Yamazaki, Y.3
  • 33
    • 55249084211 scopus 로고    scopus 로고
    • Amelioration of the premature aging-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23
    • DeLuca S., Sitara D., Kang K., et al. Amelioration of the premature aging-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23. J Pathol 2008, 216:345-355.
    • (2008) J Pathol , vol.216 , pp. 345-355
    • DeLuca, S.1    Sitara, D.2    Kang, K.3
  • 34
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • Urakawa I., Yamazaki Y., Shimada T., et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006, 444:770-774.
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3
  • 35
    • 70350552306 scopus 로고    scopus 로고
    • Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model
    • Nakatani T., Ohnishi M., Razzaque M.S. Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model. FASEB J 2009, 23:3702-3711.
    • (2009) FASEB J , vol.23 , pp. 3702-3711
    • Nakatani, T.1    Ohnishi, M.2    Razzaque, M.S.3
  • 36
    • 65649129465 scopus 로고    scopus 로고
    • FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?
    • Razzaque M.S. FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?. Am J Physiol Renal Physiol 2009, 296:F470-F476.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Razzaque, M.S.1
  • 37
    • 78650668099 scopus 로고    scopus 로고
    • Phosphate toxicity: new insights into an old problem
    • Razzaque M.S. Phosphate toxicity: new insights into an old problem. Clin Sci (Lond) 2011, 120:91-97.
    • (2011) Clin Sci (Lond) , vol.120 , pp. 91-97
    • Razzaque, M.S.1
  • 38
    • 77953778295 scopus 로고    scopus 로고
    • Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372
    • Razzaque M.S. Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372. Expert Opin Ther Pat 2010, 20:981-985.
    • (2010) Expert Opin Ther Pat , vol.20 , pp. 981-985
    • Razzaque, M.S.1
  • 39
    • 58249095115 scopus 로고    scopus 로고
    • Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype
    • Bai X., Dinghong Q., Miao D., Goltzman D., Karaplis A.C. Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype. Am J Physiol Endocrinol Metab 2009, 296:E79-E88.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Bai, X.1    Dinghong, Q.2    Miao, D.3    Goltzman, D.4    Karaplis, A.C.5
  • 40
    • 34848871595 scopus 로고    scopus 로고
    • A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
    • Ichikawa S., Imel E.A., Kreiter M.L., et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest 2007, 117:2684-2691.
    • (2007) J Clin Invest , vol.117 , pp. 2684-2691
    • Ichikawa, S.1    Imel, E.A.2    Kreiter, M.L.3
  • 41
    • 77956637592 scopus 로고    scopus 로고
    • Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging
    • Ohnishi M., Razzaque M.S. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 2010, 24:3562-3571. 10.1096/fj.1009-152488.
    • (2010) FASEB J , vol.24 , pp. 3562-3571
    • Ohnishi, M.1    Razzaque, M.S.2
  • 42
    • 77449126558 scopus 로고    scopus 로고
    • In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-Dihydroxyvitamin D levels
    • Ohnishi M., Nakatani T., Lanske B., Razzaque M.S. In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-Dihydroxyvitamin D levels. Circ Cardiovasc Genet 2009, 2:583-590.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 583-590
    • Ohnishi, M.1    Nakatani, T.2    Lanske, B.3    Razzaque, M.S.4
  • 43
    • 50849104780 scopus 로고    scopus 로고
    • Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
    • e1000154
    • Sitara D., Kim S., Razzaque M.S., et al. Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet 2008, 4. e1000154.
    • (2008) PLoS Genet , vol.4
    • Sitara, D.1    Kim, S.2    Razzaque, M.S.3
  • 44
    • 33646238028 scopus 로고    scopus 로고
    • Premature ageing-like phenotype in fibroblast growth factor 23 null mice is a vitamin-D mediated process
    • Razzaque M.S., Sitara D., Taguchi T., St-Arnaud R., Lanske B. Premature ageing-like phenotype in fibroblast growth factor 23 null mice is a vitamin-D mediated process. FASEB J 2006, 20:720-722.
    • (2006) FASEB J , vol.20 , pp. 720-722
    • Razzaque, M.S.1    Sitara, D.2    Taguchi, T.3    St-Arnaud, R.4    Lanske, B.5
  • 45
    • 33746341155 scopus 로고    scopus 로고
    • Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice
    • Razzaque M.S., Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med 2006, 12:298-305.
    • (2006) Trends Mol Med , vol.12 , pp. 298-305
    • Razzaque, M.S.1    Lanske, B.2
  • 46
    • 77956642900 scopus 로고    scopus 로고
    • Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    • Hu M.C., Shi M., Zhang J., et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 2010, 24:3438-3450.
    • (2010) FASEB J , vol.24 , pp. 3438-3450
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 47
    • 65649103814 scopus 로고    scopus 로고
    • Initial FGF23-mediated signaling occurs in the distal convoluted tubule
    • Farrow E.G., Davis S.I., Summers L.J., White K.E. Initial FGF23-mediated signaling occurs in the distal convoluted tubule. J Am Soc Nephrol 2009, 20:955-960.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 955-960
    • Farrow, E.G.1    Davis, S.I.2    Summers, L.J.3    White, K.E.4
  • 48
    • 33746036030 scopus 로고    scopus 로고
    • Klotho protein promotes adipocyte differentiation
    • Chihara Y., Rakugi H., Ishikawa K., et al. Klotho protein promotes adipocyte differentiation. Endocrinology 2006, 147:3835-3842.
    • (2006) Endocrinology , vol.147 , pp. 3835-3842
    • Chihara, Y.1    Rakugi, H.2    Ishikawa, K.3
  • 49
    • 40149102029 scopus 로고    scopus 로고
    • Klotho as a regulator of oxidative stress and senescence
    • Kuro-o M. Klotho as a regulator of oxidative stress and senescence. Biol Chem 2008, 389:233-241.
    • (2008) Biol Chem , vol.389 , pp. 233-241
    • Kuro-o, M.1
  • 50
    • 36849017126 scopus 로고    scopus 로고
    • The parathyroid is a target organ for FGF23 in rats
    • Ben-Dov I.Z., Galitzer H., Lavi-Moshayoff V., et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 2007, 117:4003-4008.
    • (2007) J Clin Invest , vol.117 , pp. 4003-4008
    • Ben-Dov, I.Z.1    Galitzer, H.2    Lavi-Moshayoff, V.3
  • 51
    • 0346849707 scopus 로고    scopus 로고
    • Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
    • Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 2003, 17:2393-2403.
    • (2003) Mol Endocrinol , vol.17 , pp. 2393-2403
    • Tsujikawa, H.1    Kurotaki, Y.2    Fujimori, T.3    Fukuda, K.4    Nabeshima, Y.5
  • 53
    • 47749148805 scopus 로고    scopus 로고
    • Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
    • Cha S.K., Ortega B., Kurosu H., Rosenblatt K.P., Kuro-o M., Huang C.L. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A 2008, 105:9805-9810.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9805-9810
    • Cha, S.K.1    Ortega, B.2    Kurosu, H.3    Rosenblatt, K.P.4    Kuro-o, M.5    Huang, C.L.6
  • 55
    • 11244270453 scopus 로고    scopus 로고
    • Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets
    • Bresler D., Bruder J., Mohnike K., Fraser W.D., Rowe P.S. Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets. J Endocrinol 2004, 183:R1-R9.
    • (2004) J Endocrinol , vol.183
    • Bresler, D.1    Bruder, J.2    Mohnike, K.3    Fraser, W.D.4    Rowe, P.S.5
  • 56
    • 44449138422 scopus 로고    scopus 로고
    • Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption
    • Dobbie H., Unwin R.J., Faria N.J., Shirley D.G. Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Nephrol Dial Transplant 2008, 23:730-733.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 730-733
    • Dobbie, H.1    Unwin, R.J.2    Faria, N.J.3    Shirley, D.G.4
  • 57
    • 33750454816 scopus 로고    scopus 로고
    • Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    • Feng J.Q., Ward L.M., Liu S., et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 2006, 38:1310-1315.
    • (2006) Nat Genet , vol.38 , pp. 1310-1315
    • Feng, J.Q.1    Ward, L.M.2    Liu, S.3
  • 58
    • 14044267649 scopus 로고    scopus 로고
    • Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors
    • Carpenter T.O., Ellis B.K., Insogna K.L., Philbrick W.M., Sterpka J., Shimkets R. Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. J Clin Endocrinol Metab 2005, 90:1012-1020.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1012-1020
    • Carpenter, T.O.1    Ellis, B.K.2    Insogna, K.L.3    Philbrick, W.M.4    Sterpka, J.5    Shimkets, R.6
  • 59
    • 33750427897 scopus 로고    scopus 로고
    • DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
    • Lorenz-Depiereux B., Bastepe M., Benet-Pages A., et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet 2006, 38:1248-1250.
    • (2006) Nat Genet , vol.38 , pp. 1248-1250
    • Lorenz-Depiereux, B.1    Bastepe, M.2    Benet-Pages, A.3
  • 60
    • 0344945402 scopus 로고    scopus 로고
    • Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers
    • Larsson T., Nisbeth U., Ljunggren O., Juppner H., Jonsson K.B. Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int 2003, 64:2272-2279.
    • (2003) Kidney Int , vol.64 , pp. 2272-2279
    • Larsson, T.1    Nisbeth, U.2    Ljunggren, O.3    Juppner, H.4    Jonsson, K.B.5
  • 61
    • 0034810211 scopus 로고    scopus 로고
    • Severely reduced production of klotho in human chronic renal failure kidney
    • Koh N., Fujimori T., Nishiguchi S., et al. Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun 2001, 280:1015-1020.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 1015-1020
    • Koh, N.1    Fujimori, T.2    Nishiguchi, S.3
  • 62
    • 20844461345 scopus 로고    scopus 로고
    • Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients
    • Kazama J.J., Sato F., Omori K., et al. Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients. Kidney Int 2005, 67:1120-1125.
    • (2005) Kidney Int , vol.67 , pp. 1120-1125
    • Kazama, J.J.1    Sato, F.2    Omori, K.3
  • 64
    • 33747719260 scopus 로고    scopus 로고
    • Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men
    • Antoniucci D.M., Yamashita T., Portale A.A. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocrinol Metab 2006, 91:3144-3149.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3144-3149
    • Antoniucci, D.M.1    Yamashita, T.2    Portale, A.A.3
  • 65
    • 33845322655 scopus 로고    scopus 로고
    • Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
    • Nishida Y., Taketani Y., Yamanaka-Okumura H., et al. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int 2006, 70:2141-2147.
    • (2006) Kidney Int , vol.70 , pp. 2141-2147
    • Nishida, Y.1    Taketani, Y.2    Yamanaka-Okumura, H.3
  • 66
    • 49249104701 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    • Gutierrez O.M., Mannstadt M., Isakova T., et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 2008, 359:584-592.
    • (2008) N Engl J Med , vol.359 , pp. 584-592
    • Gutierrez, O.M.1    Mannstadt, M.2    Isakova, T.3
  • 67
    • 61849155234 scopus 로고    scopus 로고
    • Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients
    • Hsu H.J., Wu M.S. Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients. Am J Med Sci 2009, 337:116-122.
    • (2009) Am J Med Sci , vol.337 , pp. 116-122
    • Hsu, H.J.1    Wu, M.S.2
  • 68
    • 74449086740 scopus 로고    scopus 로고
    • Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
    • Komaba H., Goto S., Fujii H., et al. Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients. Kidney Int 2010, 77:232-238.
    • (2010) Kidney Int , vol.77 , pp. 232-238
    • Komaba, H.1    Goto, S.2    Fujii, H.3
  • 71
    • 58049191428 scopus 로고    scopus 로고
    • Does FGF23 toxicity influence the outcome of chronic kidney disease?
    • Razzaque M.S. Does FGF23 toxicity influence the outcome of chronic kidney disease?. Nephrol Dial Transplant 2009, 24:4-7.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 4-7
    • Razzaque, M.S.1
  • 72
    • 36349009201 scopus 로고    scopus 로고
    • Can fibroblast growth factor 23 fine-tune therapies for diseases of abnormal mineral ion metabolism?
    • Razzaque M.S. Can fibroblast growth factor 23 fine-tune therapies for diseases of abnormal mineral ion metabolism?. Nat Clin Pract Endocrinol Metab 2007, 3:788-789.
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 788-789
    • Razzaque, M.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.