High HIV type 1 group M pol diversity and low rate of antiretroviral resistance mutations among the uniformed services in Kinshasa, Democratic Republic of the Congo

AIDS Research and Human Retroviruses

Volumn 27, Issue 3, 2011, Pages 323-329

  Djoko, Cyrille F ^a,b,c   Rimoin, Anne W ^d   Vidal, Nicole ^e   Tamoufe, Ubald ^a,b   Wolfe, Nathan D ^a,b,f   Butel, Christelle ^e   Lebreton, Matthew ^a,b   Tshala, Felix M ^g   Kayembe, Patrick K ^h   Muyembe, Jean Jacques ⁱ   Edidi Basepeo, Samuel ^j   Pike, Brian L ^a,b   Fair, Joseph N ^a,b   Mbacham, Wilfred F ^c   Saylors, Karen E ^a,b   Mpoudi Ngole, Eitel ^k   Delaporte, Eric ^e,l   Grillo, Michael ^m   Peeters, Martine ^e  

^a Global Viral Forecasting Initiative   (United States)

^b Global Viral Forecasting Initiative   (Cameroon)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^f STANFORD UNIVERSITY   (United States)

^g Military Health Services   (Congo)

^h Kinshasa School of Public Health   (Congo)

ⁱ National Institute for Biomedical Research   (Congo)

^j National AIDS Control Program Laboratory   (Congo)

^k Institute of Medical Research and Medicinal Plant Studies Yaounde   (Cameroon)

^l MONTPELLIER UNIVERSITY HOSPITAL   (France)

^m NONE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PROTEINASE INHIBITOR;

ADULT; ARTICLE; DEMOCRATIC REPUBLIC CONGO; FEMALE; GENE MUTATION; GENETIC VARIABILITY; HIGH RISK BEHAVIOR; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFORMED CONSENT; MAJOR CLINICAL STUDY; MALE; MOSAIC VIRUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOLDIER; VIRUS CLASSIFICATION; VIRUS MUTATION; VIRUS STRAIN;

ADULT; ANTI-RETROVIRAL AGENTS; DEMOCRATIC REPUBLIC OF THE CONGO; DRUG RESISTANCE, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENES, POL; GENETIC VARIATION; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; MILITARY PERSONNEL; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION;

EID: 79952587398     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2010.0201     Document Type: Article

References (26)

1. Keele BF, Van Heuverswyn F, Li Y, et al.: Chimpanzee res-ervoirs of pandemic and non-pandemic HIV-1. Science 2006;313: 523-526. (Pubitemid 44148457)
2. Van Heuverswyn F, Li Y, Neel C, et al.: Human immuno-deficiency viruses: SIV infection in wild gorillas. Nature 2006;444:164. (Pubitemid 44722051)
3. Worobey M, Gemmel M, Teuwen DE, et al.: Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960. Nature 2008;455:661-664.
4. Vidal N, Peeters M, Mulanga-Kabeya C, et al.: Un-precedented degree of human immunodeficiency virus type 1 (HIV-1) group M genetic diversity in the Democratic Re-public of Congo suggests that the HIV-1 pandemic origi-nated in Central Africa. J Virol 2000;74:10498-10507.
5. Yang C, Li M, Mokili JL, et al.: Genetic diversification and recombination of HIV type 1 group M in Kinshasa, Demo-cratic Republic of Congo. AIDS Res Hum Retroviruses 2005;21:661-666. (Pubitemid 41113655)
6. Vidal N, Mulanga C, Bazepeo SE, et al.: Distribution of HIV-1 variants in the Democratic Republic of Congo suggests increase of subtype C in Kinshasa between 1997 and 2002. J Acquir Immune Defic Syndr 2005;40:456-462. (Pubitemid 41669181)
7. Behets F, Edmonds A, Kitenge F, Crabbé F, and Laga M for the PTME Group: Heterogeneous and decreasing HIV prevalence among women seeking antenatal care in Kin-shasa, Democratic Republic of Congo. Int J Epidemiol 2010;39(4):1066-1073.
8. Ba O, O'Regan C, Nachega J et al.: HIV/AIDS in African militaries: An ecological analysis. Med Confl Surviv 2008;24:88-100.
9. Omba Kalonda JC: Sexual violence in the Democratic Re-public of Congo: Impact on public health? Med Trop (Mars) 2008;68:576-578.
10. Vergne L, Bourgeois A, Mpoudi-Ngole E, et al.: Biological and genetic characteristics of HIV infections in Cameroon reveals dual group M and O infections and a correlation between SI-inducing phenotype of the predominant CRF02-AG variant and disease stage. Virology 2003;17:851-855.
11. Vidal N, Mulanga C, Bazepeo ES, Kasali MJ, et al.: HIV type 1 pol gene diversity and antiretroviral drug resistance mu-tations in the Democratic Republic of Congo (DRC). AIDS Res Hum Retroviruses 2006;22:202-206. (Pubitemid 43277157)
12. Vidal N, Bazepeo SE, Mulanga C, Delaporte E, and Peeters M: Genetic characterization of eight full-length HIV type 1 genomes from the Democratic Republic of Congo (DRC) reveal a new subsubtype, A5, in the A radiation that pre-dominates in the recombinant structure of CRF26-A5U. AIDS Res Hum Retroviruses 2009;25:823-832.
13. Niama FR, Vidal N, Bazepeo SE, et al.: CRF45-AKU, a cir-culating recombinant from Central Africa, is probably the common ancestor of HIV type 1 MAL and HIV type 1 NOGIL. AIDS Res Hum Retroviruses 2009;25:1345-1353.
14. Thompson JD, Gibson TJ, Plewniak F, et al.: The CLUS-TAL-X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997;25:4876-4882.
15. Bennett DE, Camacho RJ, Otelea D, et al.: Drug resistance mutations for surveillance of transmitted HIV-1 drug resis-tance: 2009 update. Plos One 2009;4(3):e4724.
16. Kalish ML, Robbins KE, Pieniazek D, et al.: Recombinant viruses and early global HIV-1 epidemic. Emerg Infect Dis 2004;10:1227-1234. (Pubitemid 38890933)
17. Kita K, Ndembi N, Ekwalanga M, et al.: Genetic diversity of HIV type 1 in Likasi, Southeast of the Democratic Republic of Congo. AIDS Res Hum Retroviruses 2004;20: 1352-1357. (Pubitemid 40065931)
18. Niama FR, Toure-Kane C, Vidal N, et al.: HIV-1 subtypes and recombinants in the Republic of Congo. Infect Genet Evol 2006;6:337-343. (Pubitemid 43964477)
19. Bártolo I, Rocha C, Bartolomeu J, et al.: Highly divergent subtypes and new recombinant forms prevail in the HIV/AIDS epidemic in Angola: New insights into the origins of the AIDS pandemic. Infect Genet Evol 2009;9:672-682.
20. Yamaguchi J, Badreddine S, Swanson P, et al.: Identification of new CRF43-02G and CRF25-cpx in Saudi Arabia based on full genome sequence analysis of six HIV type 1 isolates. AIDS Res Hum Retroviruses 2008;24:1327-1335.
21. Powell RL, Zhao J, Konings FA, et al.: Circulating recombi-nant form (CRF) 37-cpx: An old strain in Cameroon com-posed of diverse, genetically distant lineages of subtypes A and G AIDS Res Hum Retroviruses 2007;23:923-933.
22. Peeters M, Toure-Kane C, and Nkengasong JN: Genetic di-versity of HIV in Africa: Impact on diagnosis, treatment, vaccine development and trials. AIDS 2003;17:2547-2560. (Pubitemid 38402333)
23. Carr JK, Wolfe ND, Torimiro JN, et al.: HIV-1 recombinants with multiple parental strains in low-prevalence, remote regions of Cameroon: Evolutionary relics? Retrovirology 2010;7:39.
24. Djoko CF, Wolfe ND,Vidal N, et al.: HIV-1 pol gene diversity and genotypic antiretroviral drug resistance mutations in Malabo, Equatorial Guinea. AIDS Res Hum Retroviruses 2010;26(9):1027-1031.
25. Herbinger KH, Gerhardt M, Piyasirisilp S, et al.: Frequency of HIV type 1 dual infection and HIV diversity: Analysis of low-and high-risk populations in Mbeya Region, Tanzania. AIDS Res Hum Retroviruses 2006;22:599-606. (Pubitemid 44061395)
26. Hamers RL, Derdelinckx I, van Vugt M, et al.: The status of HIV-1 resistance to antiretroviral drugs in sub-Saharan Africa. Antivir Ther 2008;13:625-639.