Using cognitive enhancers to improve the treatment of anxiety disorders in young people: Examining the potential for D-cycloserine to augment exposure for child anxiety

Clinical Psychologist

Volumn 15, Issue 1, 2011, Pages 1-9

  Byrne, Simon P ^a   Farrell, Lara J ^b   Rapee, Ronald M ^a  

^a MACQUARIE UNIVERSITY   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

anxiety; cognitive enhancer; D cycloserine; exposure therapy; obsessive compulsive disorder

Indexed keywords

EID: 79952581381     PISSN: 13284207     EISSN: 17429552     Source Type: Journal    
DOI: 10.1111/j.1742-9552.2011.00005.x     Document Type: Review

References (51)

1. Abramowitz, J. S., Whiteside, S. P., &, Deacon, B. J., (2005). The effectiveness of treatment for paediatric obsessive-compulsive disorder: A meta-analysis. Behavior Therapy, 36, 55-63. (Pubitemid 43150332)
2. Amir, N., Freshman, M., &, Foa, E. B., (2000). Family distress and involvement in relatives of obsessive-compulsive disorder patients. Journal of Anxiety Disorders, 14, 209-217. (Pubitemid 30259296)
3. Aupperle, R. L., Hale, L. R., Chambers, R. J., Cain, S. E., Barth, F. X., Sharp, S. C.,., Savage, C. R., (2009). An fMRI study examining effects of acute D-cycloserine during symptom provocation in spider phobia. CNS Spectrum, 14 (10), 556-571.
4. Barrett, P., Healy-Farrell, L., Piacentini, J., &, March, J., (2004). Treatment of OCD in children and adolescents. In, P. Barrett, &, T. Ollendick, (Eds.), Handbook of interventions that work with children and adolescents: Prevention and treatment (pp. 187-216). West Sussex: Wiley.
5. Barrett, P. M., Farrell, L., Pina, A. A., Peris, T. S., &, Piacentini, J., (2008). Evidence-based psychosocial treatments for child and adolescent obsessive-compulsive disorder. Journal of Clinical Child and Adolescent Psychology, 37 (1), 131-155.
6. Barrett, P. M., Rasmussen, P. J., &, Healy, L., (2001). The effect of obsessive-compulsive disorder on sibling relationships in late childhood and early adolescence: Preliminary findings. The Australian Educational and Developmental Psychologist, 17 (2), 82-102.
7. Bouton, M. E., (2002). Context, ambiguity, and unlearning: Sources of relapse after behavioral extinction. Society of Biological Psychiatry, 52, 976-986. (Pubitemid 35356355)
8. Chasson, G. S., Buhlman, U., Tolin, D., Sowmya, R. R., Hannah, E. R., Rowley, T.,., Wilhelm, S., (2010). Need for speed: Evaluating slopes of OCD recovery in behavior therapy enhanced with D-cycloserine. Behaviour and Research Therapy, 48, 675-679.
9. Cooper, M., (1996). Obsessive compulsive disorder: Effects on family members. American Journal of Orthopsychiatry, 66, 296-304. (Pubitemid 26122936)
10. D'Souza, D. C., Charney, D. S., &, Krystal, J. H., (1995). Glycine site agonists of the NMDA receptor: A review. CNS Drug Reviews, 1, 227-260.
11. Davis, M., Ressler, K., Rothbaum, B. O., &, Richardson, R., (2006). Effects of D-cycloserine on extinction: Translation from preclinical to clinical work. Biological Psychiatry, 60 (4), 369-375. (Pubitemid 44215855)
12. Efron, D., Hiscock, H., Sewell, J., Cranswick, N., Vance, A., Tyl, Y., &, Luk, E., (2003). Prescribing of psychotropic medications for children by Australian pediatricians and child psychiatrists. Pediatrics, 111, 372-375. (Pubitemid 36177158)
13. Esua, C. A., Conradt, J., &, Petermann, F., (2000). Frequency, comorbidity and psychosocial impairment of specific phobia in adolescents. Journal of Clinical Child Psychology, 29, 221-231.
14. Evins, A. E., Amico, E., Posever, T. A., Toker, R., &, Goff, D. C., (2002). D-cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia. Schizophrenia Research, 56 (1-2), 19-23. (Pubitemid 34655463)
15. Falls, W. A., Miserendino, M. J., &, Davis, M., (1992). Extinction of fear-potentiated startle: Blockade by infusion of NMDA antagonist into the amygdala. Journal of Neuroscience, 12, 854-863.
16. Goodman, W. K., Price, L. H., Rasmussen, S. A., Mazure, C., Delgado, P., Heninger, G. R., &, Charney, D. S., (1989). The Yale-Brown Obsessive Compulsive Scale II. Validity. Archives of General Psychiatry, 46, 1012-1016. (Pubitemid 19278230)
17. Guastella, A. J., Dadds, M. R., Lovibond, P., Mitchell, P., &, Richardson, R., (2007). A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear. Journal of Psychiatric Research, 41, 446-471.
18. Guastella, A. J., Richardson, R., Lovibond, P. F., Rapee, R. M., Gaston, J. E., Mitchell, P., &, Dadds, M. R., (2008). A randomised controlled trial of D-cycloserine enhancement of exposure therapy for social phobia. Biological Psychiatry, 63, 544-549.
19. Hofmann, S. G., Meuret, A. E., Smits, J. A. J., Simon, N. M., Pollack, M. H., Eisenmenger, K.,., Otto, M. W., (2006). Augmentation of exposure therapy for social anxiety disorder with D-cycloserine. Archives of General Psychiatry, 63, 298-304. (Pubitemid 43345354)
20. Hunt, C., (2000). The diagnosis and nature of generalized anxiety disorder. Current Opinion in Psychiatry, 13, 157-161. (Pubitemid 30168598)
21. James, A., Soler, A., &, Weatherall, R., (2006). Cognitive behavioural therapy for anxiety disorders in children and adolescents. The Cochrane Library, 1, 1-25.
22. Kushner, M. G., Kim, S. W., Donahue, C., Thuras, P., Adson, D., Kotlyar, M.,., Foa, E. B., (2007). D-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biological Psychiatry, 62 (8), 835-838. (Pubitemid 47488217)
23. Langton, J. M., Kim, J. H., Nicholas, J., &, Richardson, R., (2007). The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat. Learning and Memory, 14, 665-668. (Pubitemid 350036777)
24. Ledgerwood, L., Richardson, R., &, Cranney, J., (2005). D-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction. Biological Psychiatry, 57 (8), 841-847. (Pubitemid 40488352)
25. Lyneham, H. J., &, Rapee, R. M., (2002). Generalized anxiety disorder in children and adolescents. In, S. Schneider, (Ed.), Anxiety disorders (pp. 158-185). Berlin: Springer-Verlag.
26. McCallum, J., Kim, J., &, Richardson, R., (2010). Impaired extinction retention of extinguished fear in adolescent rats: Effects of D-cycloserine. Neuropsychopharmacology, 35, 2134-2142.
27. Norberg, M. M., Krystal, J. H., &, Tolin, D. F., (2008). A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biological Psychiatry, 63, 1118-1126.
28. Onur, O. A., Schlaepfer, T. E., Kukolja, J., Bauer, A., Jeung, H., Patin, A.,., Hurlemann, R., (2010). The N-Methyl-D-Aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans. Biological Psychiatry, 67 (12), 1205-1211.
29. Ã-st, L. G., Svensson, L., Hellstrom, K., &, Lindwall, R., (2001). One-session treatment of specific phobias in youths: A randomized clinical trial. Journal of Consulting and Clinical Psychology, 69, 814-824. (Pubitemid 32973257)
30. Otto, M. W., Smits, J. A., &, Reese, H., (2005). Combined psychoptherapy and pharmacotherapy for mood and anxiety disorders in adults: Review and analysis. Clinical Psychologist, 12, 72-86. (Pubitemid 40309355)
31. Otto, M. W., Tolin, D., Simon, N. M., Godfrey, C., Pearlson, G. D., Shawnee, B.,., Pollack, M. H., (2010). Efficacy of D-cycloserine for enhancing response to cogntive-behavior therapy for panic disorder. Biological Psychiatry, 67, 365-370.
32. Parnas, A. S., Weber, M., &, Richardson, R., (2005). Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats. Neurobiological Learning and Memory, 83, 224-231. (Pubitemid 40488810)
33. Pediatric OCD Treatment Study Team. (2004). Cognitive-behaviour therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder. JAMA, 292, 1969-1976.
34. Posey, D. J., Kem, D. L., Swiezy, N. B., Sweeten, T. L., Wiegand, R. E., &, McDougle, C. J., (2004). A pilot study of D-cycloserine in subjects with autistic disorder. American Journal of Psychiatry, 161 (11), 2115-2117. (Pubitemid 39441414)
35. Randolph, C., Roberts, J. W., Tierney, M. C., Bravi, D., Mouradian, M. M., &, Chase, T. N., (1994). D-cycloserine treatment of Alzheimers disease. Alzheimers Disease and Associated Disorders, 8, 198-205.
36. Rapee, R. M., Kennedy, S., Ingram, M., Edwards, S. L., &, Sweeney, L., (2005). Prevention and early intervention of anxiety disorders in inhibited preschool children. Journal of Consulting and Clinical Psychology, 73 (3), 488-497. (Pubitemid 40885098)
37. Rapee, R. M., Schniering, C. A., &, Hudson, J. L., (2009). Anxiety disorders during childhood and adolescence: Origins and treatment. Annual Review of Clinical Psychology, 5, 311-341.
38. Rasmussen, S. A., &, Eisen, J. L., (1992). The epidemiology and differential diagnosis of obsessive compulsive disorder. Journal of Clinical Psychiatry, 53, 4-10.
39. Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E.,., Davis, M., (2004). Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobics to facilitate extinction of fear. Archives of General Psychiatry, 61, 1136-1144. (Pubitemid 39463415)
40. Richardson, R., Ledgerwood, L., &, Cranney, J., (2004). Facilitation of fear extinction by D-cycloserine: Theoretical and clinical implications. Learning and Memory, 11, 510-516. (Pubitemid 39299697)
41. Shaffer, D., Gould, M. S., Fisher, P., Trautman, P., Moreau, D., Kleinman, M., &, Flory, M., (1996). Psychiatric diagnosis in child and adolescent suicide. Archives General Psychiatry, 53 (4), 339-348. (Pubitemid 26115307)
42. Storch, E. A., McKay, D., Reid, J. B., Geller, D. A., Goodman, C., Lewin, A. B., &, Murphy, T. K., (2010a). D-cycloserine augmentation of cognitive-behavioral therapy: Directions for pilot research in pediatric obsessive-compulsive disorder. Child Youth Care Forum, 39, 101-112.
43. Storch, E. A., Merlo, L. J., Bengtson, M., Murphy, T. K., Lewis, M. H., Yang, M. C.,., Goodman, W. K., (2007). D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder. International Clinical Psychopharmacology, 22 (4), 230-237. (Pubitemid 46801947)
44. Storch, E. A., Murphy, T. K., Goodman, W. K., Geffken, G. R., Lewin, A. B., Henin, A.,., Geller, D. A., (2010b). A preliminary study of D-cycloserine augmentation of cognitive-behavioural therapy in pediatric obsessive-compulsive disorder. Biological Psychiatry, 68, 1073-1076.
45. Toro, J., Cervera, M., Osejo, E., &, Salamero, M., (1992). Obsessive compulsive disorder in childhood and adolescence: A clinical study. Journal of Child Psychology and Psychiatry and Allied Disciplines, 33, 1025-1037.
46. Valleni-Basile, L. A., Garrison, C. Z., Jackson, K. L., Waller, J. L., McKeown, R. E., Addy, C. L., &, Cuffe, S. P., (1995). Family and psychosocial predictors of obsessive compulsive disorder in a community sample of young adolescents. Journal of Child and Family Studies, 4, 193-206.
47. Vervliet, B., (2008). Learning and memory in conditioned fear extinction: Effects of D-cycloserine. Acta Psychologica Sinica, 127, 601-613.
48. Walker, D. L., &, Davis, M., (2002). The role of amygdala glutamate receptors in fear learning, potentiated startle, and extinction. Pharmacology, Biochemistry and Behavior, 71 (3), 379-392. (Pubitemid 34117707)
49. Wilhelm, S., Buhlmann, U., Tolin, D. F., Meunier, S. A., Pearlson, G. D., &, Reese, H., (2008). D-cycloserine augmentation of behavior therapy for obsessive compulsive disorder. American Journal of Psychiatry, 165, 335-341. (Pubitemid 351704489)
50. Woods, A. M., &, Bouton, M. E., (2006). D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response. Behavioral Neuroscience, 120 (5), 1159-1162. (Pubitemid 44584025)
51. Zohar, A. H., (1999). The epidemiology of obsessive-compulsive disorder in children and adolescents. Child and Adolescent Psychiatric Clinics of North America, 8 (3), 445-460. (Pubitemid 29360203)