Need for speed: Evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserine

Behaviour Research and Therapy

Volumn 48, Issue 7, 2010, Pages 675-679

  Chasson, Gregory S ^a   Buhlmann, Ulrike ^b   Tolin, David F ^c   Rao, Sowmya R ^a   Reese, Hannah E ^a   Rowley, Theresa ^a   Welsh, Kaitlyn S ^a   Wilhelm, Sabine ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Behavior therapy; D Cycloserine; Exposure and response prevention; Obsessive Compulsive Disorder; OCD treatment

Indexed keywords

CYCLOSERINE; PLACEBO; PSYCHOTROPIC AGENT;

ADULT; ARTICLE; BEHAVIOR THERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; OBSESSIVE COMPULSIVE DISORDER; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; TREATMENT RESPONSE; YALE BROWN OBSESSIVE COMPULSIVE SCALE SELF REPORT; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; OBSESSIVE-COMPULSIVE DISORDER; PROCEDURES; PSYCHOLOGIC TEST; SELF EVALUATION; TIME; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; BEHAVIOR THERAPY; COMBINED MODALITY THERAPY; CYCLOSERINE; FEMALE; HUMANS; INTERVIEW, PSYCHOLOGICAL; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTROPIC DRUGS; SELF ASSESSMENT (PSYCHOLOGY); TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT; SELF-ASSESSMENT;

EID: 77953363194     PISSN: 00057967     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brat.2010.03.007     Document Type: Article

References (21)

1. APA Diagnostic and statistical manual of mental disorders 2000, American Psychiatric Association, Washington, DC. 4th, Text Revision ed.
2. Baer L., Brown-Beasley M.W., Sorce J., Henriques A.I. Computer-assisted telephone administration of a structured interview for obsessive-compulsive disorder. American Journal of Psychiatry 1993, 150(11):1737-1738.
3. Engels J.M., Diehr P. Imputation of missing longitudinal data: a comparison of methods. Journal of Clinical Epidemiology 2003, 56(10):968-976.
4. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured clinical interview for DMS-IV axis I disorders, patient edition (SCID-P version 2.0) 1995, New York State Psychiatric Institute, Biometrics Research Department, New York.
5. Foa E.B., Liebowitz M.R., Kozak M.J., Davies S., Campeas R., Franklin M.E., et al. Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. American Journal of Psychiatry 2005, 162:151-161.
6. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown Obsessive Compulsive Scale-I: development, use, and reliability. Archives in General Psychiatry 1989, 46:1006-1011.
7. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., et al. The Yale-Brown obsessive compulsive inventory (Y-BOCS): validity. Archives in General Psychiatry 1989, 46:1012-1016.
8. Grabill K., Merlo L., Duke D., Harford K.L., Keeley M.L., Geffken G.R., et al. Assessment of obsessive-compulsive disorder: a review. Journal of Anxiety Disorders 2008, 22(1):1-17.
9. Hofmann S.G., Meuret A.E., Smits J.A., Simon N.A., Pollack M.H., Eisenmenger K., et al. Augmentation of exposure therapy with d-cycloserine for social anxiety disorder. Archives in General Psychiatry 2006, 63:298-304.
10. Jenike M.A. Clinical practice. Obsessive-compulsive disorder. New England Journal of Medicine 2004, 350(3):259-265.
11. Kozak M.J., Foa E.B. Mastery of obsessive-compulsive disorder: A cognitive-behavioral approach 1997, Psychological Corporation, San Antonio.
12. Kushner M.G., Kim S.W., Donahue C., Thuras P., Adson D., Kotlyar M., et al. d-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biological Psychiatry 2007, 62(8):835-838.
13. Norberg M.M., Krystal J.H., Tolin D.F. A meta-analysis of d-cycloserine and the facilitation of fear extinction and exposure therapy. Biological Psychiatry 2008, 63(12):1118-1126.
14. Pollard C.A. Behavior Therapy Institute: handbook and program description Available from:Accessed 31.12.09. http://www.ocfoundation.org/uploadedFiles/BTTI_Handbook_and_Program_Description.pdf.
15. Ressler K.J., Rothbaum B.O., Tannenbaum L., Anderson P., Graap K., Zimand E., et al. Cognitive enhancers as adjuncts to psychotherapy: use of d-cycloserine in phobic individuals to facilitate extinction of fear. Archives in General Psychiatry 2004, 61:1136-1144.
16. Rothbaum B.O. Critical parameters for d-cycloserine enhancement of cognitive-behaviorial therapy for obsessive-compulsive disorder. American Journal of Psychiatry 2008, 165(3):293-296.
17. Schruers K., Koning K., Luermans J., Haack M.J., Griez E. Obsessive-compulsive disorder: a critical review of therapeutic perspectives. Acta Psychiatrica Scandinavica 2005, 111:261-271.
18. Steketee G., Frost R., Bogart K. The Yale-Brown obsessive compulsive scale: interview versus self-report. Behaviour Research and Therapy 1996, 34(8):675-684.
19. Storch E.A., Merlo L.J., Bengtson M., Murphy T.K., Lewis M.H., Yang M.C., et al. d-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder. Internaional Clinical Psychopharmacol 2007, 22(4):230-237.
20. Van Oppen P., De Haan E., Van Balkom A.J.L.M., Spinhoven P., Hoogduin K., Van Dyck R. Cognitive therapy and exposure in vivo in the treatment of obsessive compulsive disorder. Behaviour Research and Therapy 1995, 33(4):379-390.
21. Wilhelm S., Buhlmann U., Tolin D.F., Meunier S.A., Pearlson G.D., Reese H.E., et al. Augmentation of behavior therapy with d-cycloserine for obsessive-compulsive disorder. American Journal of Psychiatry 2008, 165(3):335-341. quiz 409.