Interference potential of personal lubricants and vaginal medications on ThinPrep® pap tests

Journal of the American Board of Family Medicine

Volumn 24, Issue 2, 2011, Pages 181-186

  Feit, Tim D ^a   Mowry, Debra A ^b  

^a Dane County Cytology Center Inc   (United States)

^b UNIVERSITY OF NEBRASKA AT KEARNEY   (United States)

Author keywords

Cervical cancer; Human sexuality; Lubricants; Pap smears; Pap tests; ThinPrep ; Vaginal medications; Women's health

Indexed keywords

CARBOMER; LUBRICATING AGENT; MICONAZOLE;

ARTICLE; CELL COUNT; CELL TRANSFER; CONTROLLED STUDY; CYTOLOGY; DIAGNOSTIC TEST; FEMALE; HUMAN; HUMAN CELL; PAPANICOLAOU TEST;

ANALYSIS OF VARIANCE; ANTIFUNGAL AGENTS; FEMALE; HUMANS; LIPIDS; LUBRICANTS; MICONAZOLE; VAGINAL CREAMS, FOAMS, AND JELLIES; VAGINAL SMEARS;

EID: 79952564395     PISSN: 15572625     EISSN: 15587118     Source Type: Journal    
DOI: 10.3122/jabfm.2011.02.100086     Document Type: Article

References (30)

1. Demay RM. The Pap test. Chicago, IL: ASCP Press; 2005.
2. Dobosz J. Cytyc: testing positive for growth. 2005. Available at: http://www.forbes.com/2005/03/30/cz-jd-0330gurusow-inl.html. Accessed March 19, 2009.
3. Adams AL, Gidley J, Roberson J, Wang W, Eltoum I, Chieng DC. Clinical significance of unsatisfactory conventional Pap smears owing to inadequate squamous cellularity defined by the Bethesda 2001 criterion. Am J Clin Pathol 2005;123:738-43. (Pubitemid 40586491)
4. Nygård JF, Sauer T, Nygård M, Skare GB, Thoresen SO. CIN 2/3 and cervical cancer in an organised screening programme after an unsatisfactory or a normal Pap smear: a seven-year prospective study of the Norwegian population-based screening programme. J Med Screen 2004;11:70-6. (Pubitemid 38832525)
5. Charoenkwan K, Ninunanahaeminda K, Khunamornpong S, Srisomboon J, Thorner PS. Effects of gel lubricant on cervical cytology. Acta Cytol 2008;52:654-58.
6. Zardawi IM, Catterall N, Duncan J, Sullivan J, Warwick L. Effects of lubricant gel on conventional and liquid-based cervical smears. Acta Cytol 2003;47: 704-5. (Pubitemid 36876733)
7. Holton T, Smith D, Terry M, Madgwick A, Levine T. The effect of lubricant contamination on Thin-Prep (Cytyc) cervical cytology liquid-based preparations. Cytopathology 2008;19:236-43. (Pubitemid 351952113)
8. Evantash E. Lubricant use during Pap test collection. Bedford, MA: Hologic Inc., 2009.
9. Amies AM, Miller L, Lee SK, Koutsky L. The effect of vaginal speculum lubrication on the rate of unsatisfactory cervical cytology diagnosis. Obstet Gynecol 2002;100:889-92. (Pubitemid 35387457)
10. Casselman CW, Crutcher RA, Jadusingh IH. Use of water-soluble gel in obtaining the cervical cytologic smear. Acta Cytol 1997;41:1861-2.
11. Gilson M, Desai A, Cardoza-Favarato G, Vroman P, Thornton JA. Does gel affect cytology or comfort in the screening papanicolaou smear? J Am Board Fam Med 2006;19:340-4.
12. Griffith WF, Stuart GS, Gluck KL, Heartwell SF. Vaginal speculum lubrication and its effects on cervical cytology and microbiology. Contraception 2005;72: 60-4. (Pubitemid 40827120)
13. Harer WB, Valenzuela G Jr, Lebo D. Lubrication of the vaginal introitus and speculum does not affect Papanicolaou smears. Obstet Gynecol 2002;100:887-8. (Pubitemid 35387456)
14. Harmanli O, Jones KA. Using lubricant for speculum insertion. Obstet Gynecol 2010;116:415-7.
15. Hathaway JK, Pathak PK, Maney R. Is liquid-based Pap testing affected by water-based lubricant? Obstet Gynecol 2006;107:66-70.
16. Tavernier LA, Connor PD, Gates D. Water vs gel lubricant for cervical cytology specimens. J Fam Pract 2003;52:701-4. (Pubitemid 37412719)
17. Adriaens E, Remon JP. Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay. Sex Transm Dis 2008;35:512-6. (Pubitemid 351670547)
18. Hoda RS, Hoda SA. Fundamentals of Pap test cytology, Totowa, NJ: Humana Press; 2007.
19. Wilbur DC, Henry MR. College of American Pathologists practical guide to gynecologic cytopathology: morphology, management, and molecular methods. Northfield, IL: College of American Pathologists Press; 2008.
20. Barnhart K, Pretorius ES, Stolpen A, Malamud D. Distribution of topical medication in the human vagina as imaged by magnetic resonance imaging. Fertil Steril 2001;76:189-95. (Pubitemid 32600980)
21. Barnhart KT, Pretorius ES, Timbers K, Shera D, Shabbout M, Malamud D. In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourse. Contraception 2004;70:498-505.
22. Henderson MH, Couchman GM, Walmer DK, et al. Optical imaging and analysis of human vaginal coating by drug delivery gels. Contraception 2007;75:142-51. (Pubitemid 46108724)
23. Mauck CK, Katz D, Sandefer EP, et al. Vaginal distribution of Replens and K-Y Jelly using three imaging techniques. Contraception 2008;77:195-204.
24. Menon S, Izquierdo A, Rosen M, Hummel A, Barnhart K. The effect of ambulation on vaginal distribution of miconazole nitrate (1200 mg). J Womens Health 2007;16:703-6. (Pubitemid 47093913)
25. Pretorius ES, Timbers K, Malamud D, Barnhart K. Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse. Contraception 2002;66:443-51. (Pubitemid 37338061)
26. Bentz JS, Rowe LR, Gopez EV, Marshall CJ. The unsatisfactory ThinPrep® Pap test: missed opportunity for disease detection? Am J Clin Pathol 2002; 117:457-63.
27. Brown J, Hooper G, Kenyon CJ, et al. Spreading and retention of vaginal formulations in post-menopausal women as assessed by gamma scintigraphy. Pharm Res 1997;14:1073-8. (Pubitemid 27371409)
28. Asane GS, Nirmal SA, Rasal KB, Naik AA, Mahadik MS, Rao YM. Polymers for mucoadhesive drug delivery system: a current status. Drug Dev Ind Pharm 2008;34:1246-66.
29. Dalton P, MacDonald S, Boerner S. Acetic acid recovery of gynecologic liquid-based samples of apparent low squamous cellularity. Acta Cytol 2006;50:136-40.
30. Ransdell JS, Davey DD, Zaleski S. Clinicopathologic correlation of the unsatisfactory Papanicolaou smear. Cancer 1997;81:139-43. (Pubitemid 28275303)