Metabolic changes underlying the higher accumulation of glutathione in Saccharomyces cerevisiae mutants

Applied Microbiology and Biotechnology

Volumn 89, Issue 4, 2011, Pages 1029-1037

  Nisamedtinov, Ildar ^a,b,d   Kevvai, Kaspar ^a   Orumets, Kerti ^a,b   Arike, Liisa ^a,b   Sarand, Inga ^a,b   Korhola, Matti ^c   Paalme, Toomas ^b  

^a Competence Centre of Food and Fermentation Technologies ^*  (Estonia)

^b TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

^c UNIVERSITY OF HELSINKI   (Finland)

^d LALLEMAND SAS   (France)

Author keywords

CYS3; Cysteine; Glutathione; GSH1; Saccharomyces cerevisiae; YAP1

Indexed keywords

CYS3; CYSTEINE; GLUTATHIONE; GSH1; SACCHAROMYCES CEREVISIAE; YAP1;

AMINO ACIDS; CULTIVATION; GENE EXPRESSION;

YEAST;

CYSTEINE; GAMMA GLUTAMYLCYSTEINE; GLUTATHIONE; PROTEOME; TRANSCRIPTION FACTOR YAP1;

AMINO ACID; BIOACCUMULATION; COMPARATIVE STUDY; CONCENTRATION (COMPOSITION); GENE EXPRESSION; METABOLISM; MOLECULAR ANALYSIS; MUTATION; PEPTIDE; PROTEIN; PROTEOMICS; ULTRAVIOLET RADIATION; YEAST;

ARTICLE; CHEMOSTAT; FED BATCH CULTURE; FUNGAL METABOLISM; FUNGAL STRAIN; GENE EXPRESSION; GENETIC TRANSCRIPTION; MUTAGENESIS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; RANDOMIZED CONTROLLED TRIAL; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION; ULTRAVIOLET IRRADIATION; WILD TYPE;

CYSTEINE; DIPEPTIDES; GENE EXPRESSION PROFILING; GLUTATHIONE; MUTATION; PROTEOME; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ANALYSIS, DNA; ULTRAVIOLET RAYS;

SACCHAROMYCES CEREVISIAE;

EID: 79952535074     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2946-z     Document Type: Article

References (35)

1. Alfafara CG, Kanda A, Shioi T, Shimizu H, Shioya S, Suga K (1992a) Effect of amino acids on glutathione production by Saccharomyces cerevisiae. Appl Microbiol Biotechnol 36:538-540
2. Alfafara CG, Miura K, Shimizu H, Shioya S, Suga K (1992b) Cysteine addition strategy for maximum glutathione production in fed-batch culture of Saccharomyces cerevisiae. Appl Microbiol Biotechnol 37:141-146
3. Bachhawat AK, Ganguli D, Kaur J, Kasturia N, Thakur A, Kaur H, Kumar A, Yaday A (2009) Glutathione production in yeast. In: Satyanarayana T, Kunze G (eds) Yeast biotechnology: diversity and applications. Springer, Dordrecht, pp 259-280
4. Bagnyukova TV, Vasylkiv OY, Storey KB, Lushchak VI (2005) Catalase inhibition by amino triazole induces oxidative stress in goldfish brain. Brain Res 1052:180-186 (Pubitemid 41116776)
5. Biterova EI, Barycki JJ (2010) Structural basis for feedback and pharmacological inhibition of Saccharomyces cerevisiae glutamate cysteine ligase. J Biol Chem 285:14459-14466
6. Delaunay A, Isnard AD, Toledano MB (2000) H2O2 sensing through oxidation of the Yap1 transcription factor. EMBO J 19:5157-5166
7. Galant NJ, Wang H, Lee DR, Mucsi Z, Setiadi DH, Viskolcz B, Csizmadia IG (2009) Thermodynamic role of glutathione oxidation by peroxide and peroxybicarbonate in the prevention of Alzheimer's disease and cancer. J Phys Chem A 113:9138-9149
8. Grant CM, MacIver FH, Dawes IW (1997) Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide γ-glutamylcysteine. Mol Biol Cell 8:1699-1707 (Pubitemid 27411135)
9. Gulshan K, Rovinsky SA, Coleman ST, Moye-Rowley WS (2005) Oxidant-specific folding of Yap1p regulates both transcriptional activation and nuclear localization. J Biol Chem 280:40524-40533 (Pubitemid 41780541)
10. Hamada S, Tanaka H, Sakato K (1986) Process for producing glutathione. US Patent 4(582):801
11. Hiraishi H, Miyake T, Ono B (2008) Transcriptional regulation of Saccharomyces cerevisiae CYS3 encoding cystathionine γ-lyase. Curr Genet 53:225-234
12. Ikeno Y, Tanno K, Omori I, Yamada R (1977) Glutathione. JP patent 52(087):296
13. 30-mediated inactivation of the transcription factor Met4. Cell 102:303-314
14. Kasemets K, Nisamedtinov I, Laht T, Abner K, Paalme T (2007) Growth characteristics of Saccharomyces cerevisiae S288C in changing environmental conditions: auxo-accelerostat study. Antonie Leeuwenhoek 92:109-128 (Pubitemid 46681581)
15. Köcher T, Pichler P, Schutzbier M, Stingl C, Kaul A, Teucher N, Hasenfuss G, Penninger JM, Mechtler K (2009) High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res 8:4743-4752
16. Kono G, Harada M, Sugisaki K, Nishida M (1977) High glutathione- containing yeast. JP Patent 52(125):687
17. Kuge S, Jones N, Nomoto A (1997) Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J 16:1710-1720 (Pubitemid 27151965)
18. Lai J, Lee S, Hsieh C, Hwang C, Liao C (2008) Saccharomyces cerevisiae strains for hyper-producing glutathione and γ-glutamylcysteine and process of use. US Patent 7(371):557
19. Lee J, Godon C, Lagniel G, Spector D, Garin J, Labarre J, Toledano MB (1999) Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. J Biol Chem 274:16040-16046
20. Li Y, Wei G, Chen J (2004) Glutathione: a review on biotechnological production. Appl Microbiol Biotechnol 66:233-242 (Pubitemid 40064351)
21. Liang G, Du G, Chen J (2008) Enhanced glutathione production by using low-pH stress coupled with cysteine addition in the treatment of high cell density culture of Candida utilis. Lett Appl Microbiol 46:507-512 (Pubitemid 351537637)
22. Martin HL, Teismann P (2009) Glutathione-a review on its role and significance in Parkinson's disease. FASEB J 23:3263-3272
23. Menant A, Baudouin-Cornu P, Peyraud C, Tyers M, Thomas D (2006) Determinants of the ubiquitin-mediated degradation of the Met4 transcription factor. J Biol Chem 281:11744-11754 (Pubitemid 43855433)
24. Nisamedtinov I, Kevvai K, Orumets K, Rautio JJ, Paalme T (2010) Glutathione accumulation in ethanol-stat fed-batch culture of Saccharomyces cerevisiae with a switch to cysteine feeding. Appl Microbiol Biotechnol 87:175-183
25. Pócsi I, Prade R, Penninckx M (2004) Glutathione, altruistic metabolite in fungi. Adv Microb Physiol 49:1-76 (Pubitemid 39424007)
26. Rappsilber J, Mann M, Ishihama Y (2007) Protocol for micropurification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat Protoc 2:1896-1906 (Pubitemid 47308128)
27. Met30 complex. EMBO J 19:282-294
28. Soltaninassab SR, Sekhar KR, Meredith MJ, Freeman ML (2000) Multi-faceted regulation of γ-glutamylcysteine synthetase. J Cell Physiol 182:163-170
29. Sugiyama K, Izawa S, Inoue Y (2000) The Yap1p-dependent induction of glutathione synthesis in heat shock response of Saccharomyces cerevisiae. J Biol Chem 275:15535-15540 (Pubitemid 30337287)
30. Thomas D, Surdin-Kerjan Y (1997) Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol Mol Biol R 61:503-532 (Pubitemid 28006958)
31. Trotter EW, Grant CM (2003) Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems. EMBO Rep 4:184-188 (Pubitemid 36322161)
32. Wang Z, Tan T, Song J (2007) Effect of amino acids addition and feedback control strategies on the high-cell-density cultivation of Saccharomyces cerevisiae for glutathione production. Process Biochem 42:108-111 (Pubitemid 44738653)
33. Wen S, Zhang T, Tan T (2006) Maximizing production of glutathione by amino acid modulation and high-cell-density fed-batch culture of Saccharomyces cerevisiae. Process Biochem 41:2424-2428 (Pubitemid 44602563)
34. Wheeler GL, Trotter EW, Dawes IW, Grant CM (2003) Coupling of the transcriptional regulation of glutathione biosynthesis to the availability of glutathione and methionine via the Met4 and Yap1 transcription factors. J Biol Chem 278:49920-49928 (Pubitemid 37548827)
35. Xu H, Freitas MA (2009) MassMatrix: a database search program for rapid characterization of proteins and peptides from tandem mass spectrometry data. Proteomics 9:1548-1555