Synthesis, in vitro antimalarial and cytotoxicity of artemisinin- aminoquinoline hybrids

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1683-1686

  Lombard, Marli C ^a   N'Da, David D ^a   Breytenbach, Jaco C ^a   Smith, Peter J ^b   Lategan, Carmen A ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Artemisinin; Hybrids; Malaria; Quinoline

Indexed keywords

1 [7 CHLORO 4 (1,2 DIAMINOETHYL)QUINOLYL] 2 (10BETA DIHYDROARTEMISINOXY)ETHANE; 1 [7 CHLORO 4 (1,2 DIAMINOPROPYL)QUINOLYL] 2 (10BETA DIHYDROARTEMISINOXY)ETHANE; 1 [7 CHLORO 4 (1,3 DIAMINOPROPYL)QUINOLYL] 2 (10BETA DIHYDROARTEMISINOXY)ETHANE; 1 [7 CHLORO 4 (1,4 DIAMINOPHENYL)QUINOLYL] 2 (10BETA DIHYDROARTEMISINOXY)ETHANE; 1 [7 CHLORO 4 (2 PIPERAZINYLETHYLAMINO)QUINOLYL] 2 (10BETA DIHYDROARTEMISINOXY)ETHANE; 1 [7 CHLORO 4 (PIPERAZIN 1 YL)QUINOLYL] 2 (10BETA DIHYDROARTEMISINOXY)ETHANE; AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; CHLOROQUINE; DIHYDROARTEMISININ; OXALATE SALT; OXALIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; ARTEMISININS; CELL SURVIVAL; PLASMODIUM FALCIPARUM;

EID: 79952533967     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.103     Document Type: Article

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