Long-term hypoxia enhances cortisol biosynthesis in near-term ovine fetal adrenal cortical cells

Reproductive Sciences

Volumn 18, Issue 3, 2011, Pages 277-285

  Vargas, Vladimir E ^a   Kaushal, Kanchan M ^a   Monau, Tshepo ^a   Myers, Dean A ^b   Ducsay, Charles A ^a  

^a LOMA LINDA UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

22 kDa pro ACTH; ACTH; cAMP; PKA; POMC; StAR

Indexed keywords

CORTICOTROPIN; CYCLIC AMP; HYDROCORTISONE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROOPIOMELANOCORTIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ADRENAL CORTEX CELL; ALTITUDE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EWE; FEMALE; FETUS; HORMONAL REGULATION; HORMONE SYNTHESIS; HYDROCORTISONE RELEASE; HYPOXIA; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADRENAL CORTEX; ANIMALS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; FETAL HYPOXIA; FETUS; HYDROCORTISONE; PHOSPHOPROTEINS; PREGNANCY; SHEEP;

EID: 79952512253     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719110386242     Document Type: Article

References (42)

1. Liggins GC, Fairclough RJ, Grieves SA, Kendall JZ, Knox BS. The mechanism of initiation of parturition in the ewe. Recent Prog Horm Res. 1973;29:111-159.
2. Meaney MJ, Viau V, Bhatnagar S, et al. Cellular mechanisms underlying the development and expression of individual differences in the hypothalamic-pituitary-adrenal stress response. J Steroid Biochem Mol Biol. 1991;39(2):265-274.
3. Challis JR, Richardson BS, Rurak D, Wlodek ME, Patrick JE. Plasma adrenocorticotropic hormone and cortisol and adrenal blood flow during sustained hypoxemia in fetal sheep. Am J Obstet Gynecol. 1986;155(6):1332-1336. (Pubitemid 17201701)
4. Fletcher AJ, Gardner DS, Edwards CM, Fowden AL, Giussani DA. Development of the ovine fetal cardiovascular defense to hypoxemia towards full term. Am J Physiol Heart Circ Physiol. 2006; 291(6):H3023-H3034. (Pubitemid 44904104)
5. Raff H, Wood CE. Effect of age and blood pressure on the heart rate, vasopressin, and renin response to hypoxia in fetal sheep. Am J Physiol. 1992;263(4 pt 2):R880-R884.
6. Towell ME, Figueroa J, Markowitz S, Elias B, Nathanielsz P. The effect of mild hypoxemia maintained for twenty-four hours on maternal and fetal glucose, lactate, cortisol, and arginine vasopressin in pregnant sheep at 122 to 139 days' gestation. Am J Obstet Gynecol. 1987;157(6):1550-1557. (Pubitemid 18022892)
7. Myers DA, Bell PA, Hyatt K, Mlynarczyk M, Ducsay CA. Long-term hypoxia enhances proopiomelanocortin processing in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2005;288(5):R1178-R1184. (Pubitemid 40593700)
8. Myers DA, Hyatt K, Mlynarczyk M, Bird IM, Ducsay CA. Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2005;289(6):R1707-R1714. (Pubitemid 41643215)
9. Schwartz J, Kleftogiannis F, Jacobs R, Thorburn GD, Crosby SR, White A. Biological activity of adrenocorticotropic hormone precursors on ovine adrenal cells. Am J Physiol. 1995;268(4 pt 1):E623-E629.
10. Imamura T, Umezaki H, Kaushal KM, Ducsay CA. Long-term hypoxia alters endocrine and physiologic responses to umbilical cord occlusion in the ovine fetus. J Soc Gynecol Investig. 2004;11(3):131-140. (Pubitemid 38406091)
11. Adachi K, Umezaki H, Kaushal KM, Ducsay CA. Long-term hypoxia alters ovine fetal endocrine and physiological responses to hypotension. Am J Physiol Regul Integr Comp Physiol. 2004;287(1):R209-R217. (Pubitemid 38856329)
12. Sewer MB, Waterman MR. ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex. Microsc Res Tech. 2003;61(3):300-307. (Pubitemid 36618456)
13. Stocco DM. Star protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol. 2001;63:193-213. (Pubitemid 32304316)
14. Bell ME, McDonald TJ, Myers DA. Proopiomelanocortin processing in the anterior pituitary of the ovine fetus after lesion of the hypothalamic paraventricular nucleus. Endocrinology. 2005;146(6):2665-2673. (Pubitemid 40695569)
15. Ducsay CA, Mlynarczyk M, Kaushal KM, Hyatt K, Hanson K, Myers DA. Long-term hypoxia enhances ACTH response to arginine vasopressin but not corticotropin-releasing hormone in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2009;297(3):R892-R899.
16. Monau TR, Vargas VE, Zhang L, Myers DA, Ducsay CA. Nitric oxide inhibits ACTH-induced cortisol production in nearterm, long term hypoxic ovine fetal adrenocortical cells. Reprod Sci. 2010;17(10):955-962.
17. Daniel PB, Walker WH, Habener JF. Cyclic AMP signaling and gene regulation. Annu Rev Nutr. 1998;18:353-383. (Pubitemid 28366872)
18. Kamenetsky M, Middelhaufe S, Bank EM, Levin LR, Buck J, Steegborn C. Molecular details of camp generation in mammalian cells: A tale of two systems. J Mol Biol. 2006;362(4):623-639. (Pubitemid 44332423)
19. Myers DA, Hyatt K, Mlynarczyk M, Bird IM, Ducsay CA. Longterm hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2005;289(6):R1707-R1714. (Pubitemid 41643215)
20. Darbeida H, Durand P. Glucocorticoid enhancement of adrenocorticotropin- induced 3′,5′-cyclic adenosine monophosphate production by cultured ovine adrenocortical cells. Endocrinology. 1987;121(3):1051-1055. (Pubitemid 17139158)
21. Su Y, Rose JC. The impact of acth receptor knockdown on fetal and adult ovine adrenocortical cell function. Reprod Sci. 2008;15(3):253-262. (Pubitemid 351550935)
22. Valego NK, Rose JC. A specific crh antagonist attenuates acth-stimulated cortisol secretion in ovine adrenocortical cells. Reprod Sci. 2010;17(5):477-486.
23. Manna PR, Dyson MT, Eubank DW, et al. Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the camp response-element binding protein family. Mol Endocrinol. 2002;16(1):184-199. (Pubitemid 34044507)
24. Raff H, Hong JJ, Oaks MK, Widmaier EP. Adrenocortical responses to acth in neonatal rats: Effect of hypoxia from birth on corticosterone, star, and pbr. Am J Physiol Regul Integr Comp Physiol. 2003;284(1):R78-R85. (Pubitemid 36008658)
25. Gorostizaga A, Cornejo Maciel F, Brion L, Maloberti P, Podesta EJ, Paz C. Tyrosine phosphatases in steroidogenic cells: regulation and function. Mol Cell Endocrinol. 2007;265-266:131-137. (Pubitemid 46273956)
26. Cohen P. The structure and regulation of protein phosphatases. Annu Rev Biochem. 1989;58:453-508. (Pubitemid 19172978)
27. Ford SL, Abayasekara DR, Persaud SJ, Jones PM. Role of phosphoprotein phosphatases in the corpus luteum: I Identification and characterisation of serine/threonine phosphoprotein phosphatases in isolated rat luteal cells. J Endocrinol. 1996;150(2):205-211. (Pubitemid 26295615)
28. Sayed SB, Whitehouse BJ, ones PM. Phosphoserine/threonine phosphatases in the rat adrenal cortex: a role in the control of steroidogenesis? J Endocrinol. 1997;154(3):449-458. (Pubitemid 27375040)
29. Burns CJ, Gyles SL, Persaud SJ, Sugden D, Whitehouse BJ, Jones PM. Phosphoprotein phosphatases regulate steroidogenesis by influencing star gene transcription. Biochem Biophys Res Commun. 2000;273(1):35-39.
30. Jones PM, Sayed SB, Persaud SJ, Burns CJ, Gyles S, Whitehouse BJ. Cyclic amp-induced expression of steroidogenic acute regulatory protein is dependent upon phosphoprotein phosphatase activities. J Mol Endocrinol. 2000;24(2233-239.
31. Poderoso C, Maciel FC, Gorostizaga A, Bey P, Paz C, Podesta EJ. The obligatory action of protein tyrosine phosphatases in acthstimulated steroidogenesis is exerted at the level of star protein. Endocr Res. 2002;28(4):413-417.
32. Sewer MB, Waterman MR. cAMP-dependent transcription of steroidogenic genes in the human adrenal cortex requires a dual-specificity phosphatase in addition to protein kinase a. J Mol Endocrinol. 2002;29(1):163-174. (Pubitemid 34965754)
33. Arakane F, King SR, Du Y, et al. Phosphorylation of steroidogenic acute regulatory protein (star) modulates its steroidogenic activity. J Biol Chem. 1997;272(51):32656-32662.
34. Fleury A, Mathieu AP, Ducharme L, Hales DB, LeHoux JG. Phosphorylation and function of the hamster adrenal steroidogenic acute regulatory protein (star). J Steroid Biochem Mol Biol. 2004;91(4):259-271. (Pubitemid 39164608)
35. LeHoux JG, Fleury A, Ducharme L, Hales DB. Phosphorylation of the hamster adrenal steroidogenic acute regulatory protein as analyzed by two-dimensional polyacrylamide gel electrophoreses. Mol Cell Endocrinol. 2004;215(1-2):127-134. (Pubitemid 38333251)
36. Manna PR, Stocco DM. Regulation of the steroidogenic acute regulatory protein expression: functional and physiological consequences. Curr Drug Targets Immune Endocr Metabol Disord. 2005;5(1):93-108. (Pubitemid 40394307)
37. Orme-Johnson NR. Distinctive properties of adrenal cortex mitochondria. Biochim Biophys Acta. 1990;1020(3):213-231. (Pubitemid 120038260)
38. Pon LA, Hartigan JA, Orme-Johnson NR. Acute ACTH regulation of adrenal corticosteroid biosynthesis. Rapid accumulation of a phosphoprotein. J Biol Chem. 1986;261(28):13309-13316. (Pubitemid 17006911)
39. Yuen BS, Owens PC, Symonds ME, et al. Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep. Biol Reprod. 2004;70(6):1650-1657. (Pubitemid 38720186)
40. Pralong FP, Roduit R, Waeber G, et al. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology. 1998;139(10):4264-4268. (Pubitemid 28513714)
41. Ducsay CA, Hyatt K, Mlynarczyk M, Kaushal KM, Myers DA. Long-term hypoxia increases leptin receptors and plasma leptin concentrations in the late-gestation ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2006;291(5):R1406-R1413. (Pubitemid 44794219)
42. Vargas VE, Myers DA, Kaushal KM, Ducsay CA. ACTH induced cortisol synthesis in ovine fetal adrenocortical cells is mediated in part by extracellular signal regulated kinase (erk) 1 and 2: effect of long term hypoxia (lth). Reprod Sci. 2009;16(3):250A.