Long-term hypoxia increases leptin receptors and plasma leptin concentrations in the late-gestation ovine fetus

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 291, Issue 5, 2006, Pages

  Ducsay, Charles A ^a   Hyatt, Kim ^b   Mlynarczyk, Malgorzata ^a   Kaushal, Kanchan M ^a   Myers, Dean A ^b  

^a LOMA LINDA UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Adrenal; Hypothalamus; OB R

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; NITROGEN;

ADIPOSE TISSUE; ADRENAL CORTEX CELL; ADRENAL GLAND; ALTITUDE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL BLOOD; ARTERY CATHETER; ARTICLE; BLOOD SAMPLING; BRAIN HYPOXIA; CONTROLLED STUDY; FETUS; GESTATION PERIOD; HYPOTHALAMUS; IMPLANTATION; LABORATORY; NONHUMAN; OXYGEN TENSION; PLACENTA; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADIPOSE TISSUE; ADRENAL GLANDS; ANIMALS; ANOXIA; FEMALE; FETUS; GENE EXPRESSION REGULATION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; LEPTIN; PITUITARY-ADRENAL SYSTEM; PREGNANCY; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SHEEP;

EID: 33751262674     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00077.2006     Document Type: Article

References (50)

1. Adachi K, Umezaki H, Kaushal KM, and Ducsay CA. Long-term hypoxia alters ovine fetal endocrine and physiological responses to hypotension. Am J Physiol Regul Integr Comp Physiol 287: R209-R217, 2004.
2. Ahima RS and Flier JS. Leptin. Annu Rev Physiol 62: 413-437, 2000.
3. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, and Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252, 1996.
4. Ahima RS, Saper CB, Flier JS, and Elmquist JK. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21: 263-307, 2000.
5. Akagi K and Challis JRG. Hormonal and biophysical responses to acute hypoxemia in fetal sheep at 0.7-0.8 gestation. Can J Physiol Pharmacol 68: 1527-1532, 1990.
6. Banks AS, Davis SM, Bates SH, and Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275: 14563-14572, 2000.
7. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, and Tartaglia LA. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378, 1996.
8. Boddy K, Jones CT, Mantnell C, Ratcliffe JG, and Robinson JS. Changes in plasma ACTH and corticosteroid of the maternal and fetal sheep during hypoxia. Endocrinology 94: 588-591, 1974.
9. Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, and Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes 46: 1235-1238, 1997.
10. Chelikani PK, Glimm DR, and Kennelly JJ. Short communication: tissue distribution of leptin and leptin receptor mRNA in the bovine. J Dairy Sci 86: 2369-2372, 2003.
11. Devaskar SU, Anthony R, and Hay W Jr. Ontogeny and insulin regulation of fetal ovine white adipose tissue leptin expression. Am J Physiol Regul Integr Comp Physiol 282: R431-R438, 2002.
12. Ehrhardt RA, Bell AW, and Boisclair YR. Spatial and developmental regulation of leptin in fetal sheep. Am J Physiol Regul Integr Comp Physiol 282: R1628-R1635, 2002.
13. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, and Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23: 775-786, 1999.
14. Forhead AJ, Thomas L, Crabtree J, Hoggard N, Gardner DS, Giussani DA, and Fowden AL. Plasma leptin concentration in fetal sheep during late gestation: ontogeny and effect of glucocorticoids. Endocrinology 143: 1166-1173, 2002.
15. Ge H, Huang L, Pourbahrami T, and Li C. Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem 277: 45898-45903, 2002.
16. Green LR, Kawagoe Y, Fraser M, Challis JR, and Richardson BS. Activation of the hypothalamic-pituitary-adrenal axis with repetitive umbilical cord occlusion in the preterm ovine fetus. J Soc Gynecol Investig 7: 224-232, 2000.
17. Harvey LM, Gilbert RD, Longo LD, and Ducsay CA. Changes in ovine fetal adrenocortical responsiveness after long-term hypoxemia. Am J Physiol Endocrinol Metab 264: E741-E747, 1993.
18. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, and Flier JS. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 138: 3859-3863, 1997.
19. Henry BA, Goding JW, Alexander WS, Tilbrook AJ, Canny BJ, Dunshea F, Rao A, Mansell A, and Clarke IJ. Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function. Endocrinology 140: 1175-1182, 1999.
20. Henson MC and Castracane VD. Leptin in pregnancy. Biol Reprod 63: 1219-1228, 2000.
21. Howe DC, Gertler A, and Challis JR. The late gestation increase in circulating ACTH and cortisol in the fetal sheep is suppressed by intracerebroventricular infusion of recombinant ovine leptin. J Endocrinol 174: 259-266, 2002.
22. Imamura T, Umezaki H, Kaushal KM, and Ducsay CA. Long-term hypoxia alters endocrine and physiologic responses to umbilical cord occlusion in the ovine fetus. J Soc Gynecol Investig 11: 131-140, 2004.
23. Ip MS, Lam KS, Ho C, Tsang KW, and Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 118: 580-586, 2000.
24. Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, and Clarke IJ. Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus. Brain Res 920: 55-64, 2001.
25. Kruse M, Bornstein SR, Uhlmann K, Paeth G, and Scherbaum WA. Leptin down-regulates the steroid producing system in the adrenal. Endocr Res 24: 587-590, 1998.
26. Linnemann K, Malek A, Sager R, Blum WF, Schneider H, and Fusch C. Leptin production and release in the dually in vitro perfused human placenta. J Clin Endocrinol Metab 85: 4298-4301, 2000.
27. Liu JP, Clarke IJ, Funder JW, and Engler D. Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. J Clin Invest 93: 1439-1450, 1994.
28. Lolmede K, Durand dSF, V, Galitzky J, Lafontan M, and Bouloumie A. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord 27: 1187-1195, 2003.
29. Maamra M, Bidlingmaier M, Postel-Vinay MC, Wu Z, Strasburger CJ, and Ross RJ. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 142: 4389-4393, 2001.
30. Malendowicz LK, Neri G, Markowska A, Hochol A, Nussdorfer GG, and Majchrzak M. Effects of leptin and leptin fragments on steroid secretion of freshly dispersed rat adrenocortical cells. J Steroid Biochem Mol Biol 87: 265-268, 2003.
31. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, and Nakao K. Non-adipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029-1033, 1997.
32. McMillen IC, Muhlhausler BS, Duffield JA, and Yuen BS. Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth. Proc Nutr Soc 63: 405-412, 2004.
33. Mercer JG, Moar KM, Rayner DV, Trayhurn P, and Hoggard N. Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett 402: 185-188, 1997.
34. Muhlhausler BS, McMillen IC, Rouzaud G, Findlay PA, Marrocco EM, Rhind SM, and Adam CL. Appetite regulatory neuropeptides are expressed in the sheep hypothalamus before birth. J Neuroendocrinol 16: 502-507, 2004.
35. Murotsuki J, Gagnon R, Matthews SG, and Challis JR. Effects of long-term hypoxemia on pituitary-adrenal function in fetal sheep. Am J Physiol Endocrinol Metab 271: E678-E685, 1996.
36. Myers DA, Bell PA, Hyatt K, Mlynarczyk M, and Ducsay CA. Long-term hypoxia enhances proopiomelanocortin processing in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol 288: R1178-R1184, 2005.
37. Myers DA, Hyatt K, Mlynarczyk M, Bird IM, and Ducsay CA. Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol 289: R1707-R1714, 2005.
38. Niswender KD, Baskin DG, and Schwartz MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab 15: 362-369, 2004.
39. Plum L, Schubert M, and Bruning JC. The role of insulin receptor signaling in the brain. Trends Endocrinol Metab 16: 59-65, 2005.
40. Polotsky VY, Li J, Punjabi NM, Rubin AE, Smith PL, Schwartz AR, and O'Donnell CP. Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol 552: 253-264, 2003.
41. Pralong FP, Roduit R, Waeber G, Castillo E, Mosimann F, Thorens B, and Gaillard RC. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology 139: 4264-4268, 1998.
42. Rondini TA, Baddini SP, Sousa LF, Bittencourt JC, and Elias CF. Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats. Neuroscience 125: 735-748, 2004.
43. Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 24: 225-253, 2003.
44. Scott J, Hyatt K, and Myers DA. Developmental changes in adrenal leptin receptor expression and adrenocortical response to leptin in the ovine fetus (Abstract). J Soc Gynecol Investig 12: 239A, 2005.
45. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, and Kriauciunas A. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532, 1995.
46. Tartaglia LA. The leptin receptor. J Biol Chem 272: 6093-6096, 1997.
47. Tschop M, Strasburger CJ, Hartmann G, Biollaz J, and Bartsch P. Raised leptin concentrations at high altitude associated with loss of appetite. Lancet 352: 1119-1120, 1998.
48. Tschop M, Strasburger CJ, Topfer M, Hautmann H, Riepl R, Fischer R, Hartmann G, Morrison K, Appenzeller M, Hildebrandt W, Biollaz J, and Bartsch P. Influence of hypobaric hypoxia on leptin levels in men (Abstract). Int J Obes Relat Metab Disord 24, Suppl 2: S151, 2000.
49. Yamashita T, Murakami T, Otani S, Kuwajima M, and Shima K. Leptin receptor signal transduction: OBRa and OBRb of fa type. Biochem Biophys Res Commun 246: 752-759, 1998.
50. Yuen BS, Owens PC, Symonds ME, Keisler DH, McFarlane JR, Kauter KG, and McMillen IC. Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep. Biol Reprod 70: 1650-1657, 2004.