On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 7, 2011, Pages 2129-2132

  Haider, Shozeb ^a   Joseph, Caleb G ^b   Neidle, Stephen ^c   Fierke, Carol A ^d   Fuchter, Matthew J ^e  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF MICHIGAN   (United States)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Acetylation; Chromatin; Epigenetic; HDAC; Histones

Indexed keywords

ACETIC ACID; ARGININE; GLUTAMIC ACID; GLYCINE; HISTONE DEACETYLASE 8; HYDROGEN; OXYGEN;

ACETYLATION; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GENETIC CONSERVATION; HYDROGEN BOND; MOLECULAR INTERACTION; RESIDUE ANALYSIS; STRUCTURE ANALYSIS;

BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; HISTONE DEACETYLASES; HUMANS; MODELS, MOLECULAR; REPRESSOR PROTEINS;

EID: 79952486549     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.128     Document Type: Article

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