Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: Alone and in combination with ethanol or THC (delta-9- tetrahydrocannabinol)

Psychopharmacology

Volumn 213, Issue 4, 2011, Pages 745-756

  Lansbergen, Marieke M ^a   Dumont, Glenn J H ^a,b   Van Gerven, Joop M A ^d   Buitelaar, Jan K ^a,c   Verkes, Robbert Jan ^a  

^a RADBOUD UNIVERSITY   (Netherlands)

^b Moleman Psychopharmacology   (Netherlands)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

Author keywords

Acute effects; Alcohol; Cannabis; Ecstasy; EEG; Ethanol; Healthy volunteers; MDMA; Neuronal oscillations; THC

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; DRONABINOL; PLACEBO;

ADULT; ALCOHOL CONSUMPTION; ALPHA RHYTHM; ARTICLE; BLOOD LEVEL; BRAIN FUNCTION; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; FEMALE; HALLUCINATION; HUMAN; HUMAN EXPERIMENT; MALE; NEUROTOXICOLOGY; NORMAL HUMAN; OSCILLATION; PRIORITY JOURNAL; TASK PERFORMANCE; THETA RHYTHM; TOXICOKINETICS;

ADOLESCENT; ADULT; BRAIN; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; ELECTROENCEPHALOGRAPHY; ETHANOL; FEMALE; HALLUCINOGENS; HUMANS; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; TETRAHYDROCANNABINOL; YOUNG ADULT;

EID: 79952486269     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2031-4     Document Type: Article

References (62)

1. Abrams DI, Vizoso HP, Shade SB, Jay C, Kelly ME, Benowitz NL (2007) Vaporization as a smokeless cannabis delivery system: a pilot study. Clin Pharmacol Ther 82:572-578
2. Barrett SP, Gross SR, Garand I, Pihl RO (2005) Patterns of simultaneous polysubstance use in Canadian rave attendees. Subst Use Misuse 40:1525-1537 (Pubitemid 41098807)
3. Böcker KBE, Hunault CC, Gerritsen J, Kruidenier M, Mensinga TT, Kenemans JL (2010) Cannabinoid modulations of resting state EEG theta power and working memory are correlated in humans. J Cogn Neurosci 22:1906-1916
4. Boha R, Molnar M, Gaal ZA, Czigler B, Rona K, Kass K et al (2009) The acute effect of low-dose alcohol on working memory during mental arithmetic: I. Behavioral measures and EEG theta band spectral characteristics. Int J Psychophysiol 73:133-137
5. Boys A, Marsden J, Strang J (2001) Understanding reasons for drug use amongst young people: a functional perspective. Health Educ Res 16:457-469 (Pubitemid 32769161)
6. Choi YH, Hazekamp A, Peltenburg-Looman AM, Frederich M, Erkelens C, Lefeber AW et al (2004) NMR assignments of the major cannabinoids and cannabiflavonoids isolated from flowers of Cannabis sativa. Phytochem Anal 15:345-354 (Pubitemid 39591953)
7. Colado MI, O'Shea E, Green AR (2004) Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function. Psychopharmacology (Berl) 173:249-263 (Pubitemid 38703798)
8. de la Torre R, Farre M, Roset PN, Pizarro N, Abanades S, Segura M et al (2004) Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit 26:137-144 (Pubitemid 38501207)
9. Doppelmayr M, Klimesch W, Pachinger T, Ripper B (1998) Individual differences in brain dynamics: important implications for the calculation of event-related band power. Biol Cybern 79:49-57 (Pubitemid 128636495)
10. Dumont GJ, Verkes RJ (2006) A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers. J Psychopharmacol 20:176-187
11. Dumont GJ, Wezenberg E, Valkenberg MM, de Jong CA, Buitelaar JK, van Gerven JM et al (2008) Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers. Psychopharmacology (Berl) 197:465-474
12. Dumont GJ, Kramers C, Sweep FC, Touw DJ, van Hasselt JG, de Kam M et al (2009a) Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans. Clin Pharmacol Ther 86:160-166
13. Dumont GJ, Sweep FC, van der Steen R, Hermsen R, Donders AR, Touw DJ et al (2009b) Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. Soc Neurosci 4:359-366
14. Dumont GJ, Kramers C, Sweep FC, Willemsen JJ, Touw DJ, Schoemaker RC et al (2010a) Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology. J Psychopharmacol 24:165-174
15. Dumont GJ, Schoemaker RC, Touw DJ, Sweep FC, Buitelaar JK, van Gerven JM et al (2010b) Acute psychomotor effects of MDMA and ethanol (co-)administration over time in healthy volunteers. J Psychopharmacol 24:155-164
16. Dumont GJ, van Hasselt JGC, de Kam M, van Gerven JM, Touw DJ, Buitelaar JK et al (2010c) Acute psychomotor, memory and subjective effects of MDMA and THC (co-)administration over time in healthy volunteers. J Psychopharmacol (in press). doi:10.1177/0269881110376687
17. Duzel E, Penny WD, Burgess N (2010) Brain oscillations and memory. Curr Opin Neurobiol 20:143-149
18. Ehlers CL, Wall TL, Schuckit MA (1989) EEG spectral characteristics following ethanol administration in young men. Electroencephalogr Clin Neurophysiol 73:179-187 (Pubitemid 19212498)
19. First MB, Frances AJ, Pincus HA, Vettorello N, Davis WW (1994) DSM-IV in progress. Changes in substance-related, schizophrenic, and other primarily adult disorders. Hosp Community Psychiatry 45:18-20
20. Frei E, Gamma A, Pascual-Marqui R, Lehmann D, Hell D, Vollenweider FX (2001) Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA). Hum Brain Mapp 14:152-165 (Pubitemid 33032348)
21. Gouzoulis-Mayfrank E, Daumann J (2006) The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview. J Psychopharmacol 20:188-193
22. Gratton G, Coles MG, Donchin E (1983) A new method for off-line removal of ocular artifact. Electroencephalogr Clin Neurophysiol 55:468-484 (Pubitemid 13112654)
23. Green B, Kavanagh D, Young R (2003) Being stoned: a review of self-reported cannabis effects. Drug Alcohol Rev 22:453-460 (Pubitemid 37496019)
24. Greicius MD, Krasnow B, Reiss AL, Menon V (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100(1):253-258 (Pubitemid 36078061)
25. Gulick D, Gould TJ (2007) Acute ethanol has biphasic effects on short- and long-term memory in both foreground and background contextual fear conditioning in C57BL/6 mice. Alcohol Clin Exp Res 31:1528-1537 (Pubitemid 47319666)
26. 1H-NMR. Chem Pharm Bull (Tokyo) 52:718-721
27. Hazekamp A, Ruhaak R, Zuurman L, van Gerven J, Verpoorte R (2006) Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetrahydrocannabinol. J Pharm Sci 95:1308-1317 (Pubitemid 43874444)
28. Ilan AB, Gevins A (2001) Prolonged neurophysiological effects of cumulative wine drinking. Alcohol 25:137-152 (Pubitemid 34143109)
29. Ilan AB, Smith ME, Gevins A (2004) Effects of marijuana on neurophysiological signals of working and episodic memory. Psychopharmacology (Berl) 176:214-222 (Pubitemid 39517951)
30. Ilan AB, Gevins A, Coleman M, ElSohly MA, de Wit H (2005) Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids. Behav Pharmacol 16:487-496 (Pubitemid 41404822)
31. Jann K, Dierks T, Boesch C, Kottlow M, Strik W, Koenig T (2009) BOLD correlates of EEG alpha phase-locking and the fMRI default mode network. Neuroimage 45(3):903-916
32. Jensen O, Tesche CD (2002) Frontal theta activity in humans increases with memory load in a working memory task. Eur J Neurosci 15:1395-1399 (Pubitemid 35478001)
33. Jensen O, Gelfand J, Kounios J, Lisman JE (2002) Oscillations in the alpha band (9-12 Hz) increase with memory load during retention in a short-term memory task. Cereb Cortex 12:877-882 (Pubitemid 34803887)
34. Kahana MJ (2006) The cognitive correlates of human brain oscillations. J Neurosci 26:1669-1672
35. Klimesch W (1999) EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res Rev 29:169-195
36. Knyazev GG (2007) Motivation, emotion, and their inhibitory control mirrored in brain oscillations. Neurosci Biobehav Rev 31:377-395
37. Kuypers KP, Ramaekers JG (2007) Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected. Psychopharmacology (Berl) 189(4):557-563 (Pubitemid 44791224)
38. Lamers CT, Ramaekers JG, Muntjewerff ND, Sikkema KL, Samyn N, Read NL et al (2003) Dissociable effects of a single dose of ecstasy (MDMA) on psychomotor skills and attentional performance. J Psychopharmacol 17(4):379-387 (Pubitemid 38076332)
39. Laufs H (2008) Endogenous brain oscillations and related networks detected by surface EEG-combined fMRI. Hum Brain Mapp 29(7):762-769
40. Liechti ME, Vollenweider FX (2000) Acute psychological and physiological effects of MDMA ("ecstasy") after haloperidol pretreatment in healthy humans. Eur Neuropsychopharmacol 10:289-295 (Pubitemid 30394604)
41. Liechti ME, Vollenweider FX (2001) Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies. Hum Psychopharmacol 16:589-598 (Pubitemid 34036939)
42. Little HJ (1999) The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol. Pharmacol Ther 84:333-353
43. Lukas SE, Mendelson JH, Benedikt RA, Jones B (1986) EEG alpha activity increases during transient episodes of ethanol-induced euphoria. Pharmacol Biochem Behav 25:889-895 (Pubitemid 17179910)
44. Lukas SE, Mendelson JH, Benedikt R (1995) Electroencephalographic correlates of marihuana-induced euphoria. Drug Alcohol Depend 37:131-140
45. Mitchell DJ, McNaughton N, Flanagan D, Kirk IJ (2008) Frontal-midline theta from the perspective of hippocampal "theta". Prog Neurobiol 86:156-185
46. Mlinar B, Corradetti R (2003) Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons. Eur J Neurosci 18:1559-1571 (Pubitemid 37215109)
47. Oken BS, Salinsky MC, Elsas SM (2006) Vigilance, alertness, or sustained attention: physiological basis and measurement. Clin Neurophysiol 117:1885-1901 (Pubitemid 44262514)
48. Parrott AC (2007) Ecstasy versus alcohol: Tolstoy and the variations of unhappiness. J Psychopharmacol 21:3-6
49. Pifl C, Drobny H, Reither H, Hornykiewicz O, Singer EA (1995) Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Mol Pharmacol 47:368-373
50. Sauseng P, Klimesch W, Heise KF, Gruber WR, Holz E, Karim AA et al (2009) Brain oscillatory substrates of visual short-term memory capacity. Curr Biol 19:1846-1852
51. Sauseng P, Griesmayr B, Freunberger R, Klimesch W (2010) Control mechanisms in working memory: a possible function of EEG theta oscillations. Neurosci Biobehav Rev 34:1015-1022
52. Sprague JE, Brutcher RE, Mills EM, Caden D, Rusyniak DE (2004) Attenuation of 3, 4-methylenedioxymethamphetamine (MDMA, ecstasy)-induced rhabdomyolysis with alpha1-plus beta3-adrenoreceptor antagonists. Br J Pharmacol 142:667-670
53. Stenberg G, Sano M, Rosen I, Ingvar DH (1994) EEG topography of acute ethanol effects in resting and activated normals. J Stud Alcohol 55:645-656 (Pubitemid 24356266)
54. Strougo A, Zuurman L, Roy C, Pinquier JL, van Gerven JM, Cohen AF et al (2008) Modelling of the concentration-effect relationship of THC on central nervous system parameters and heart rate - insight into its mechanisms of action and a tool for clinical research and development of cannabinoids. J Psychopharmacol 22:717-726
55. Svrakic DM, Whitehead C, Przybeck TR, Cloninger CR (1993) Differential diagnosis of personality disorders by the seven-factor model of temperament and character. Arch Gen Psychiatry 50:991-999 (Pubitemid 23361479)
56. Tran Y, Craig A, Bartrop R, Nicholson G (2004) Time course and regional distribution of cortical changes during acute alcohol ingestion. Int J Neurosci 114:863-878 (Pubitemid 38856529)
57. Vengeliene V, Bilbao A, Molander A, Spanagel R (2008) Neuropharmacology of alcohol addiction. Br J Pharmacol 154:299-315 (Pubitemid 351670598)
58. Zoethout RW, van Gerven JM, Dumont GJ, Paltansing S, van Burgel ND, van der Linden M et al (2008) A comparative study of two methods for attaining constant alcohol levels. Br J Clin Pharmacol 66:674-681
59. Zoethout RW, Schoemaker RC, Zuurman L, van Pelt H, Dahan A, Cohen AF et al (2009) Central nervous system effects of alcohol at a pseudo-steady-state concentration using alcohol clamping in healthy volunteers. Br J Clin Pharmacol 68:524-534
60. Zuurman L, Roy C, Schoemaker RC, Hazekamp A, den Hartigh J, Bender JC et al (2008) Effect of intrapulmonary tetrahydrocannabinol administration in humans. J Psychopharmacol 22:707-716
61. Zuurman L, Ippel AE, Moin E, van Gerven JM (2009) Biomarkers for the effects of cannabis and THC in healthy volunteers. Br J Clin Pharmacol 67:5-21
62. Zuurman L, Roy C, Schoemaker RC, Amatsaleh A, Guimaeres L, Pinquier JL et al (2010) Inhibition of THC-induced effects on the central nervous system and heart rate by a novel CB1 receptor antagonist AVE1625. J Psychopharmacol 24:363-371