Acute psychomotor effects of MDMA and ethanol (co-) administration over time in healthy volunteers

Journal of Psychopharmacology

Volumn 24, Issue 2, 2010, Pages 155-164

  Dumont, G J H ^a   Schoemaker, R C ^b   Touw, D J ^c   Sweep, F C G J ^a   Buitelaar, J K ^a   Van Gerven, J M A ^b   Verkes, R J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

^c Clinical Pharmaceutical and Toxicological Laboratory   (Netherlands)

Author keywords

Dynamics; Ethanol; Human; Kinetics; MDMA; Psychomotor

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; HYDROCORTISONE; PLACEBO; PROLACTIN;

ADULT; ALCOHOL BLOOD LEVEL; ARTICLE; BLOOD LEVEL; BODY EQUILIBRIUM; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PSYCHOMOTOR ACTIVITY; PSYCHOMOTOR DISORDER; SACCADIC EYE MOVEMENT; SEDATION; SMOOTH PURSUIT EYE MOVEMENT;

ADOLESCENT; ADULT; ALCOHOLIC INTOXICATION; AROUSAL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; ETHANOL; FEMALE; HALLUCINOGENS; HUMANS; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PSYCHOMOTOR PERFORMANCE; TIME FACTORS; YOUNG ADULT;

EID: 76649095990     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108099214     Document Type: Article

References (44)

1. Amatsaleh, AA, Dumont, GJ, Schoemaker, RC, van Gerven, JM (2006 a) Optimisation of a novel method for alcohol infusion by clamping of breath alcohol concentration. Br J Clin Pharmacol 61: 475.
2. Amatsaleh, AA, Schoemaker, RC, van Gerven, JM (2006 b) Investigation of the effects of ethanol on central nervous system parameters in healthy volunteers. Br J Clin Pharmacol 61: 626.
3. Barrett, SP, Gross, SR, Garand, I., Pihl, RO (2005) Patterns of simultaneous polysubstance use in Canadian rave attendees. Subst Use Misuse 40: 1525-1537.
4. Colado, MI, OShea, E., Green, AR (2004) Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function. Psychopharmacology (Berl) 173: 249-263.
5. de la Torre, R., Farre, M., Ortuno, J., Mas, M., Brenneisen, R., Roset, PN, et al. (2000 a) Non-linear pharmacokinetics of MDMA (ecstasy) in humans. BrJ Clin Pharmacol 49: 104-109.
6. de la Torre, R., Farre, M., Roset, PN, Lopez, CH, Mas, M., Ortuno, J., et al. (2000 b) Pharmacology of MDMA in humans. Ann N Y Acad Sci 914: 225-237.
7. de la Torre, R., Farre, M., Roset, PN, Pizarro, N., Abanades, S., Segura, M., et al. (2004) Human pharmacology of MDMA - pharmacokinetics, metabolism, and disposition. Ther Drug Monit 26: 137-144.
8. Dumont, GJ, Valkenberg, MM, Schoemaker, R., Buitelaar, JK, van Gerven, JM, Verkes, RJ (2007) Acute MDMA and ethanol interaction effects on psychomotor performance. Br J Clin Pharmacol 63: 503.
9. Dumont, GJ, Wezenberg, E., Valkenberg, Mmgj Jong de, CAJ, Buitelaar, JK, Gerven van, JMA, et al. (2008) Acute neuropsychological effects of MDMA and ethanol (co-) administration in healthy volunteers. Psychopharmacology (Berl) 197: 465-474.
10. First, MB, Frances, AJ, Pincus, HA, Vettorello, N., Davis, WW (1994) DSM-IV in progress. Changes in substance-related, schizophrenic, and other primarily adult disorders. Hosp Community Psychiatry 45: 18-20.
11. Gijsman, HJ, van Gerven, JM, Verkes, RJ, Schoemaker, RC, Pieters, MS, Pennings, EJ, et al. (2002) Saccadic peak velocity and EEG as end-points for a serotonergic challenge test. Hum Psychopharmacol 17: 83-89.
12. Gouzoulis-Mayfrank, E., Daumann, J. (2006) The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overview. J Psychopharmacol 20: 188-193.
13. Green, AR, Mechan, AO, Elliott, JM, OShea, E., Colado, MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Rev 55: 463-508.
14. Gross, SR, Barrett, SP, Shestowsky, JS, Pihl, RO (2002) Ecstasy and drug consumption patterns: a Canadian rave population study. Can J Psychiatry 47: 546-551.
15. Gulick, D., Gould, TJ (2007) Acute ethanol has biphasic effects on short- and long-term memory in both foreground and background contextual fear conditioning in C57BL/6 mice. Alcohol Clin Exp Res 31: 1528-1537.
16. Harris, DS, Baggott, M., Mendelson, JH, Mendelson, JE, Jones, RT (2002) Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans. Psychopharmacology (Berl) 162: 396-405.
17. Hernandez-Lopez, C., Farre, M., Roset, PN, Menoyo, E., Pizarro, N., Ortuno, J., et al. (2002) 3,4-methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics. J Pharmacol Exp Ther 300: 236-244.
18. Izco, M., Orio, L., OShea, E., Colado, MI (2007) Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain. Psychopharmacology (Berl) 189: 459-470.
19. Kuypers, KP, Samyn, N., Ramaekers, JG (2006) MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function. Psychopharmacology (Berl) 187: 467-475.
20. Lamas, X., Farre, M., Llorente, M., Cami, J. (1994) Spanish version of the 49-item short form of the Addiction Research Center Inventory (ARCI). Drug Alcohol Depend 35: 203-209.
21. Lamers, CTJ, Ramaekers, JG, Muntjewerff, ND, Sikkema, KL, Samyn, N., Read, NL, et al. (2003) Dissociable effects of a single dose of ecstasy (MDMA) on psychomotor skills and attentional performance. J Psychopharmacol (Oxf) 17: 379-387.
22. Liechti, ME, Vollenweider, FX (2000) The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine (Ecstasy) in healthy volunteers. J Psychopharmacol (Oxf) 14: 269-274.
23. Liechti, ME, Vollenweider, FX (2001) Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies. Hum Psychopharmacol 16: 589-598.
24. Mas, M., Farre, M., de la Torre, R., Roset, PN, Ortuno, J., Segura, J., et al. (1999) Cardiovascular and neuroendocrine effects and pharmacokinetics of 3, 4-methylenedioxymethamphetamine in humans. J Pharmacol Exp Ther 290: 136-145.
25. Meeren, HK, Van Luijtelaar, EL, Coenen, AM (1998) Cortical and thalamic visual evoked potentials during sleep-wake states and spike-wave discharges in the rat. Electroencephalogr Clin Neuro-physiol 108: 306-319.
26. Mehta, MA, Riedel, WJ (2006) Dopaminergic enhancement of cognitive function. Curr Pharm Des 12: 2487-2500.
27. Mlinar, B., Corradetti, R. (2003) Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons. Eur J Neuroscience 18: 1559-1571.
28. Nyberg, S., Wahlstrom, G., Backstrom, T., Poromaa, IS (2004) No difference in responsiveness to a low dose of alcohol between healthy women and men. Pharmacol Biochem Behav 78: 603-610.
29. Orban de Xivry, JJ, Lefevre, P. (2007) Saccades and pursuit: two outcomes of a single sensorimotor process. J Physiol 584: 11-23.
30. Pacifici, R., Zuccaro, P., Lopez, CH, Pichini, S., Di Carlo, S., Farre, M., et al. (2001) Acute effects of 3,4-methylenedioxymethamphetamine alone and in combination with ethanol on the immune system in humans. J Pharmacol Exp Ther 296: 207-215.
31. Parrott, AC (2001) Human psychopharmacology of Ecstasy (MDMA). a review of 15 years of empirical research. Hum Psychopharmacol 16: 557-577.
32. Parrott, AC (2006) MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress. J Psychopharmacol 20: 147-163.
33. Pifl, C., Drobny, H., Reither, H., Hornykiewicz, O., Singer, EA (1995) Mechanism of the dopamine-releasing actions of amphetamine and cocaine - plasmalemmal dopamine transporter versus vesicular monoamine transporter. Mol Pharmacol 47: 368-373.
34. Pohorecky, LA, Brick, J. (1988) Pharmacology of ethanol. Pharmacol Ther 36: 335-427.
35. Ramaekers, JG, Kuypers, KP (2006) Acute effects of 3,4- methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol. Neuropsychopharmacology 31: 1048-1055.
36. Riley, SC, James, C., Gregory, D., Dingle, H., Cadger, M. (2001) Patterns of recreational drug use at dance events in Edinburgh, Scotland. Addiction 96: 1035-1047.
37. Sprague, JE, Brutcher, RE, Mills, EM, Caden, D., Rusyniak, DE (2004) Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists. Br J Pharmacol 142: 667-670.
38. Sundstrom, I., Backstrom, T. (1998) Citalopram increases pregnanolone sensitivity in patients with premenstrual syndrome: an open trial. Psychoneuroendo 23: 73-88.
39. Suzdak, PD, Schwartz, RD, Skolnick, P., Paul, SM (1988) Alcohols stimulate gamma-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency. Brain Res 444: 340-345.
40. Svrakic, DM, Whitehead, C., Przybeck, TR, Cloninger, CR (1993) Differential diagnosis of personality disorders by the seven-factor model of temperament and character. Arch Gen Psychiatry 50: 991-999.
41. Tanner-Smith, EE (2006) Pharmacological content of tablets sold as "ecstasy": results from an online testing service. Drug Alcohol Depend 83: 247-254.
42. van Steveninck, AL, van Berckel, BN, Schoemaker, RC, Breimer, DD, van Gerven, JM, Cohen, AF (1999) The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation. J Psychopharmacol 13: 10-17.
43. Winstock, AR, Griffiths, P., Stewart, D. (2001) Drugs and the dance music scene: a survey of current drug use patterns among a sample of dance music enthusiasts in the UK. Drug Alcohol Depend 64: 9-17.
44. Wright, BM (1971) A simple mechanical ataxia-meter. J Physiol 218: 27P - 28P.