Preventive and therapeutic coenzyme Q10 supplementation in rat subjected to cerebrovascular ischemia-reperfusion injury

Current Neurobiology

Volumn 1, Issue 1, 2010, Pages 30-36

  Horecky J ^a   Aliev, G ^b   Gvozdjakova A ^c   Kucharska J ^c   Vancova O ^c  

^a SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^b The University of Texas at San Antonio   (United States)

^c Comenius University School of Medicine ^*  (Slovakia)

Author keywords

Coenzyme Q10; Endogenous antioxidants; Rat; TBARS; Three vessel occlusion

Indexed keywords

ALPHA TOCOPHEROL; LI Q SORB; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UBIDECARENONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN DAMAGE; BRAIN MITOCHONDRION; BRAIN PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIMARY PREVENTION; RAT; REPERFUSION INJURY; SUPPLEMENTATION; TRANSIENT ISCHEMIC ATTACK; VITAMIN BLOOD LEVEL;

EID: 79952463768     PISSN: 09759042     EISSN: 09761705     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. De la Torre JC. Critical threshold cerebral hypoperfusion causes Alzheimer's disease? Acta Neuropathol 1999; 98:1-8.
2. Aliev G, Palacios HH, Walrafen B, Lipssid AE, Obrenovich ME, Morales L. Brian mitochondria as a primary target in the development of treatment strategies for Alzheimer disease. Int J Biochem Cell Biol 2009;41:1989-2004.
3. Kogure K, Arai H, Abe K, Nakano M. Free radical damage of the brain following ischemia. Prog Brain Res 1985;63:237-259.
4. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21:2-14.
5. Jenkins LW, Povlishock JT, Lewelt W, Miller JD, Becker DP. The role of postischemic recirculation on the development of ischemic neuronal injury following complete cerebral ischemia. Acta Neuropathol 1981;55:205.
6. Mori T, Asano T, Matsui T, Muramatsu H, Ueda M, Kamiya T, Katayama Y, Abe T. Intraluminal increase of superoxide anion following transient focal cerebral ischemia in rats. Brain Res 1999;816:350-357.
7. Horecký J, BaČiak L, VanČová O, Wimmerová S, Kašparová S. Effects of transient ischemia on rat brain energy metabolism assessed in vivo by 31P MRS and in vitro by mitochondrial OXPHOS. Biochim Biophys Acta - Bioenergetics 2006;Suppl S:178-179.
8. Horecký J, BaČiak L, Kašparová S, Pacheco G, Aliev G, VanČová O. Minimally invasive surgical approache for three-vessel occlusion as a model of vascular dementia in the rat - brain bioenergetics assay. J Neurol Sci 2009;283(1-2):178-181.
9. Sarma JSM, Shigeaki I, Fischer R, Maruyama Y, Weishaar R, Bing RJ. Biochemical and contractile properties of heart muscle after prolonged alcohol administration. J Mol Cell Cardiol 1976;8(12):951-972.
10. Lowry HO, Rosebrough NJ, Farr AL, Randal RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265.
11. Lang JK, Gohil K, Packer L. Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal Biochem 1986;157:106-116.
12. Kucharska J, Gvozdiakova A, Mizera S, Braunová Z, Schreinerova Z, Schramekova E, Pechan I, Fabian J. Participation of coenzyme Q10 in the rejection development of the transplanted heart: a clinical study. Physiol Res 1998;47:399-404.
13. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358.
14. Janero DR, Burghardt B. Thiobarbituric acid-reactive malondialdehyde formation during superoxide-dependent, iron-catalyzed lipid peroxidation: Influence of peroxidation conditions. Lipids 1989;24:125-131.
15. Aliev G, Smith MA, de la Torre JC, Perry G. Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzhaimer̀s disease. Mitochondrion 2004; (5-6): 649-663.
16. De la Torre JC, Fortin T, Park GAS Pappas BA, Richard MT. Brain blood flow restoration ̀rescues̀ chronically damaged rat CA1 neurons. Brain Res 1993; 623: 6-15-28.
17. Pulsinelly WA, Brierley JB, Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 1982;11: 491-498.
18. Schmidt-Kastner R, Freund TF. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991; 40: 599-636.
19. Sims NR, Pulsinelli WA. Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat. J Neurochem 1987;49(5):1367-1374.
20. Sciamanna MA, Lee CP. Ischemia/reperfusion-induced injury of forebrain mitochondria and protection by ascorbate. Arch Biochem Biophys 1993;35(2):215-224.
21. Aliev G, Gasimov E, Obrenovich ME, Fischbach K, Shenk JC, Smith MA, Perry G. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: Implication in the pathogenesis of Alzheimer̀s disease. Vascular Health and Risk Management 2008;4(3):721-730.
22. Halliwell B, Gutteridge JMC. Oxygen radicals and the nervous system. Trends Neurosci 1985;8:22-26.
23. Aliev G, Obrenovich ME, Reddy VP, Shenk JC, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Antioxidant therapy in Alzheimer̀s disease: theory and practice. Mini Rev Med Chem 2008;8(13):1395-1406.
24. Candelairo-Jalil E, Mhadu NH, Al-Dalain SM, Martinez G, Leon OS. The course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci Res 2001;41:233-241.
25. Frank L, Massaro D. Oxygen toxicity. Am J Med 1980;69:117-126.
26. Ames BN, Shigenda MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993;90:7915-7922.
27. Crane FL, Navas P. The diversity of coenzyme Q function. Molec Aspects Med 1997;18:81-86.
28. James AM, Smith RA, Murphy MP. Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch Biochem Biophys 2004;423:47-56.
29. Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta 2004;1660:171-199.
30. ZhangY, Aberg F, Appelkvist E-L, Dallner G, Ernster L. Uptake of dietary coenzyme Q supplement is limited in rats. J Nutr 1995;125:446-453.
31. Zhang Y, Turunen M, Appelkvist E-L. Restricted uptake of coenzyme Q is in contrast to unrestricted uptake of α-tocopherol into rat organs and cells. J Nutr 1996;126:2089-2097.
32. 10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med 2002;33:627-638.