B cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model

Cell Communication and Signaling

Volumn 9, Issue , 2011, Pages

  Dufner, Almut ^a,b,d   Schamel, Wolfgang W ^b,c,d  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CASPASE RECRUITMENT DOMAIN PROTEIN 11; CELL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; PROTEIN BCL 10; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; GENE; LIPID RAFT; MALT1 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 79952457236     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-9-6     Document Type: Article

References (41)

1. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. J Ruland, GS Duncan, A Elia, I del Barco Barrantes, L Nguyen, S Plyte, DG Millar, D Bouchard, A Wakeham, PS Ohashi, TW Mak, Cell 2001 104 33 42 10.1016/S0092-8674(01)00189-1 11163238 (Pubitemid 32144970)
2. The MAGUK family protein CARD11 is essential for lymphocyte activation. H Hara, T Wada, C Bakal, I Kozieradzki, S Suzuki, N Suzuki, M Nghiem, EK Griffiths, C Krawczyk, B Bauer, F D'Acquisto, S Ghosh, WC Yeh, G Baier, R Rottapel, JM Penninger, Immunity 2003 18 763 775 10.1016/S1074-7613(03)00148-1 12818158 (Pubitemid 36776426)
3. MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit. U Ferch, CM zum Buschenfelde, A Gewies, E Wegener, S Rauser, C Peschel, D Krappmann, J Ruland, Nat Immunol 2007 8 984 991 10.1038/ni1493 17660823 (Pubitemid 47300013)
4. Differential requirement for Malt1 in T and B cell antigen receptor signaling. J Ruland, GS Duncan, A Wakeham, TW Mak, Immunity 2003 19 749 758 10.1016/S1074-7613(03)00293-0 14614861 (Pubitemid 37490799)
5. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. AA Ruefli-Brasse, DM French, VM Dixit, Science 2003 302 1581 1584 10.1126/science.1090769 14576442 (Pubitemid 37475705)
6. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. TT Su, B Guo, Y Kawakami, K Sommer, K Chae, LA Humphries, RM Kato, S Kang, L Patrone, R Wall, M Teitell, M Leitges, T Kawakami, DJ Rawlings, Nat Immunol 2002 3 780 786 12118249
7. Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha. K Saijo, I Mecklenbrauker, A Santana, M Leitger, C Schmedt, A Tarakhovsky, J Exp Med 2002 195 1647 1652 10.1084/jem.20020408 12070292 (Pubitemid 34666078)
8. Phosphorylation of the CARMA1 linker controls NF-kappaB activation. K Sommer, B Guo, JL Pomerantz, AD Bandaranayake, ME Moreno-Garcia, YL Ovechkina, DJ Rawlings, Immunity 2005 23 561 574 10.1016/j.immuni.2005.09.014 16356855 (Pubitemid 41779479)
9. Antigen-receptor signaling to nuclear factor kappa B. J Schulze-Luehrmann, S Ghosh, Immunity 2006 25 701 715 10.1016/j.immuni.2006.10. 010 17098202 (Pubitemid 46107295)
10. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. H Zhou, I Wertz, K O'Rourke, M Ultsch, S Seshagiri, M Eby, W Xiao, VM Dixit, Nature 2004 427 167 171 10.1038/nature02273 14695475 (Pubitemid 38094958)
11. Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. PB Shambharkar, M Blonska, BP Pappu, H Li, Y You, H Sakurai, BG Darnay, H Hara, J Penninger, X Lin, Embo J 2007 26 1794 1805 10.1038/sj.emboj.7601622 17363905 (Pubitemid 46624041)
12. Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. A Oeckinghaus, E Wegener, V Welteke, U Ferch, SC Arslan, J Ruland, C Scheidereit, D Krappmann, Embo J 2007 26 4634 4645 10.1038/sj.emboj.7601897 17948050 (Pubitemid 350126802)
13. NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation. CJ Wu, JD Ashwell, Proc Natl Acad Sci USA 2008 105 3023 3028 10.1073/pnas.0712313105 18287044 (Pubitemid 351723661)
14. Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets. MW Tusche, LA Ward, F Vu, D McCarthy, M Quintela-Fandino, J Ruland, JL Gommerman, TW Mak, J Exp Med 2009 206 2671 2683 10.1084/jem.20091802 19917778
15. LPS/TLR4 signal transduction pathway. YC Lu, WC Yeh, PS Ohashi, Cytokine 2008 42 145 151 10.1016/j.cyto.2008.01.006 18304834
16. Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. N Cusson-Hermance, S Khurana, TH Lee, KA Fitzgerald, MA Kelliher, J Biol Chem 2005 280 36560 36566 10.1074/jbc.M506831200 16115877 (Pubitemid 41587731)
17. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. L Xue, SW Morris, C Orihuela, E Tuomanen, X Cui, R Wen, D Wang, Nat Immunol 2003 4 857 865 10.1038/ni963 12910267 (Pubitemid 37098656)
18. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. Y Liu, W Dong, L Chen, R Xiang, H Xiao, G De, Z Wang, Y Qi, J Biol Chem 2004 279 37436 37444 10.1074/jbc.M400241200 15213237 (Pubitemid 39195453)
19. The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. W Dong, Y Liu, J Peng, L Chen, T Zou, H Xiao, Z Liu, W Li, Y Bu, Y Qi, J Biol Chem 2006 281 26029 26040 10.1074/jbc.M513057200 16831874 (Pubitemid 44401809)
20. A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. N Suzuki, S Suzuki, DG Millar, M Unno, H Hara, T Calzascia, S Yamasaki, T Yokosuka, NJ Chen, AR Elford, J Suzuki, A Takeuchi, C Mirtsos, D Bouchard, PS Ohashi, WC Yeh, T Saito, Science 2006 311 1927 1932 10.1126/science.1124256 16574867
21. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. T Kawagoe, S Sato, A Jung, M Yamamoto, K Matsui, H Kato, S Uematsu, O Takeuchi, S Akira, J Exp Med 2007 204 1013 1024 10.1084/jem.20061523 17485511 (Pubitemid 46798146)
22. IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses. E Lye, S Dhanji, T Calzascia, AR Elford, PS Ohashi, Eur J Immunol 2008 38 870 876 10.1002/eji.200737429 18286567
23. Control of B-cell responses by Toll-like receptors. C Pasare, R Medzhitov, Nature 2005 438 364 368 10.1038/nature04267 16292312 (Pubitemid 41643953)
24. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. JH Fritz, L Le Bourhis, G Sellge, JG Magalhaes, H Fsihi, TA Kufer, C Collins, J Viala, RL Ferrero, SE Girardin, DJ Philpott, Immunity 2007 26 445 459 10.1016/j.immuni.2007.03.009 17433730 (Pubitemid 46604867)
25. Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. S Minguet, EP Dopfer, C Pollmer, MA Freudenberg, C Galanos, M Reth, M Huber, WW Schamel, Eur J Immunol 2008 38 2475 2487 10.1002/eji.200738094 18819072
26. Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. FJ Quintana, A Solomon, IR Cohen, G Nussbaum, PLoS ONE 2008 3 3509 10.1371/journal.pone.0003509 18946502
27. IRAK-4 - a shared NF-kappaB activator in innate and acquired immunity. N Suzuki, T Saito, Trends Immunol 2006 27 566 572 10.1016/j.it.2006.10.003 17046325 (Pubitemid 44708832)
28. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. N Suzuki, S Suzuki, GS Duncan, DG Millar, T Wada, C Mirtsos, H Takada, A Wakeham, A Itie, S Li, JM Penninger, H Wesche, PS Ohashi, TW Mak, WC Yeh, Nature 2002 416 750 756 10.1038/nature736 11923871 (Pubitemid 34429152)
29. The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling. S Flannery, AG Bowie, Biochem Pharmacol 2010 80 1981 1991 10.1016/j.bcp.2010.06.020 20599782
30. R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. M Huber, C Kalis, S Keck, Z Jiang, P Georgel, X Du, L Shamel, S Sovath, S Mudd, B Beutler, C Galanos, MA Freudenberg, Eur J Immunol 2006 36 701 711 10.1002/eji.200535593 16506285
31. IRAK1: a critical signaling mediator of innate immunity. S Gottipati, NL Rao, WP Fung-Leung, Cell Signal 2008 20 269 276 10.1016/j.cellsig.2007.08.009 17890055
32. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. B He, R Santamaria, W Xu, M Cols, K Chen, I Puga, M Shan, H Xiong, JB Bussel, A Chiu, A Puel, J Reichenbach, L Marodi, R Doffinger, J Vasconcelos, A Issekutz, J Krause, G Davies, X Li, B Grimbacher, A Plebani, E Meffre, C Picard, C Cunningham-Rundles, JL Casanova, A Cerutti, Nat Immunol 2010 11 836 845 10.1038/ni.1914 20676093
33. The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. PN Moynagh, Trends Immunol 2009 30 33 42 10.1016/j.it.2008.10.001 19022706
34. Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling. KY Yu, HJ Kwon, DA Norman, E Vig, MG Goebl, MA Harrington, J Immunol 2002 169 4075 4078 12370331 (Pubitemid 35178172)
35. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. L Salmena, B Lemmers, A Hakem, E Matysiak-Zablocki, K Murakami, PY Au, DM Berry, L Tamblyn, A Shehabeldin, E Migon, A Wakeham, D Bouchard, WC Yeh, JC McGlade, PS Ohashi, R Hakem, Genes Dev 2003 17 883 895 10.1101/gad.1063703 12654726 (Pubitemid 36397376)
36. Requirement for caspase-8 in NF-kappaB activation by antigen receptor. H Su, N Bidere, L Zheng, A Cubre, K Sakai, J Dale, L Salmena, R Hakem, S Straus, M Lenardo, Science 2005 307 1465 1468 10.1126/science.1104765 15746428 (Pubitemid 40321944)
37. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. DR Beisner, IL Ch'en, RV Kolla, A Hoffmann, SM Hedrick, J Immunol 2005 175 3469 3473 16148088 (Pubitemid 41292003)
38. The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation. H Kawadler, MA Gantz, JL Riley, X Yang, Mol Cell 2008 31 415 421 10.1016/j.molcel.2008.06.008 18691973
39. Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation. AA Ruefli-Brasse, WP Lee, S Hurst, VM Dixit, J Biol Chem 2004 279 1570 1574 10.1074/jbc.C300460200 14638696 (Pubitemid 38082688)
40. CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation. A Dufner, GS Duncan, A Wakeham, AR Elford, HT Hall, PS Ohashi, TW Mak, Mol Cell Biol 2008 28 1541 1552 10.1128/MCB.01359-07 18160713
41. Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. A Dufner, S Pownall, TW Mak, Proc Natl Acad Sci USA 2006 103 988 993 10.1073/pnas.0510380103 16418290 (Pubitemid 43212209)