Acute lipophilicity-dependent effect of intravascular simvastatin in the early phase of focal cerebral ischemia

Neuropharmacology

Volumn 60, Issue 6, 2011, Pages 878-885

  Beretta, S ^a   Pastori, C ^b   Sala, G ^a   Piazza, F ^a   Ferrarese, C ^a   Cattalini, A ^b   De Curtis, M ^b   Librizzi, L ^b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

Acute effect; Blood brain barrier; In vitro isolated guinea pig brain; Simvastatin; Transient focal ischemia

Indexed keywords

HYDROXYACID; LACTONE; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SIMVASTATIN;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; EVOKED RESPONSE; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; VASCULAR RESISTANCE;

ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; GUINEA PIGS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFUSIONS, INTRAVENOUS; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS C-AKT; SIMVASTATIN; SOLUBILITY; VASCULAR RESISTANCE;

EID: 79952451823     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.01.003     Document Type: Article

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