Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 1999-2008

  Ye, Na ^a   Wu, Qianqian ^a   Zhu, Liyuan ^a   Zheng, Longtai ^b   Gao, Bo ^b   Zhen, Xuechu ^a,b   Zhang, Ao ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

5 HT1A receptor; Aporphine analogues; Arylpiperazine; Click reaction; Dopamine D3 receptor

Indexed keywords

1 (2 AZIDOETHYL) 4 (2 METHOXYPHENYL)PIPERAZINE; 1 (3 AZIDOPROPYL) 4 (2 METHOXYPHENYL)PIPERAZINE; 1 (3 AZIDOPROPYL) 4 (2,3 DICHLOROPHENYL)PIPERAZINE; 1 (3 AZIDOPROPYL) 4 PHENYLPIPERAZINE; 1 [4 (3 AZIDOPROPYL)PIPERAZIN 1 YL]PYRIMIDINE; 1 ARYLPIPERAZINE; 11 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTOXY] N PROPYLNORAPORPHINE; 11 [[1 [3 (4 PHENYLPIPERAZIN 2 YL)PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] N PROPYLNORAPORPHINE; 11 [[1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] N PROPYLNORAPORPHINE; 11 [[1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] N PROPYLNORAPORPHINE; 11 [[1 [3 [4 (2,3 DICHLOROPHENYL)PIPERAZIN 1 YL]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] N PROPYLNORAPORPHINE; 11 O (3 AZIDOPROPYL) N PROPYLNORAPORPHINE; 3 [3 (N PROPYLNORAPORPHIN 11 YLOXY)PROPYLAMINO]PROPAN 1 OL; APORPHINE DERIVATIVE; DOPAMINE 3 RECEPTOR; N [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] N [3 (N PROPYLNORAPORPHIN 11 YLOXY)PROPYL]METHANESULFONAMIDE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; STRUCTURE ACTIVITY RELATION;

APORPHINES; DOPAMINE AGENTS; HEK293 CELLS; HUMANS; PIPERAZINES; PROTEIN BINDING; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952445993     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.053     Document Type: Article

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