메뉴 건너뛰기




Volumn 88, Issue 11-12, 2011, Pages 535-542

Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: Diclofenac-induced gastrointestinal, liver, and encephalopathy lesions

Author keywords

BPC 157; Diclofenac; NSAIDs; Rats; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DICLOFENAC; DRINKING WATER; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE;

EID: 79952444480     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.01.015     Document Type: Article
Times cited : (73)

References (50)
  • 1
    • 67449152242 scopus 로고    scopus 로고
    • Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: A relation with NO-system
    • D. Balenovic, M.L. Bencic, M. Udovicic, K. Simonji, J.S. Hanzevacki, and I. Barisic Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system Regul Pept 156 2009 83 89
    • (2009) Regul Pept , vol.156 , pp. 83-89
    • Balenovic, D.1    Bencic, M.L.2    Udovicic, M.3    Simonji, K.4    Hanzevacki, J.S.5    Barisic, I.6
  • 3
    • 5744224983 scopus 로고    scopus 로고
    • Pharmacology and medical management of hepatic cirrhosis and fibrosis
    • B.M. Bilir, and N. Bilir Pharmacology and medical management of hepatic cirrhosis and fibrosis G. Friedman, E.D. Jacobson, R.W. McCallum, Gastrointestinal Pharmacology and Therapeutics 1997 Lippincontt-Raven Publishers Philadelphia 449 464
    • (1997) Gastrointestinal Pharmacology and Therapeutics , pp. 449-464
    • Bilir, B.M.1    Bilir, N.2
  • 4
    • 4544366244 scopus 로고    scopus 로고
    • The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice
    • DOI 10.1016/j.ejphar.2004.07.112, PII S0014299904009070
    • A.B. Blagaic, V. Blagaic, Z. Romic, and P. Sikiric The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice Eur J Pharmacol 499 2004 285 290 (Pubitemid 39233667)
    • (2004) European Journal of Pharmacology , vol.499 , Issue.3 , pp. 285-290
    • Blagaic, A.B.1    Blagaic, V.2    Romic, Z.3    Sikiric, P.4
  • 7
    • 57349168116 scopus 로고    scopus 로고
    • Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury
    • X. Deng, M.J. Liguori, E.M. Sparkenbaugh, J.F. Waring, E.A. Blomme, and P.E. Ganey Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury J Pharmacol Exp Ther 327 2008 634 644
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 634-644
    • Deng, X.1    Liguori, M.J.2    Sparkenbaugh, E.M.3    Waring, J.F.4    Blomme, E.A.5    Ganey, P.E.6
  • 9
    • 34848817401 scopus 로고    scopus 로고
    • Alcohol-induced steatosis in liver cells
    • T.M. Donohue Jr. Alcohol-induced steatosis in liver cells World J Gastroenterol 13 2007 4974 4978 (Pubitemid 47496830)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.37 , pp. 4974-4978
    • Donohue Jr., T.M.1
  • 10
    • 0035840836 scopus 로고    scopus 로고
    • Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs
    • DOI 10.1016/S0014-2999(01)01327-9, PII S0014299901013279
    • S.M. Evans, and B.J. Whittle Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs Eur J Pharmacol 429 2001 287 296 (Pubitemid 33044003)
    • (2001) European Journal of Pharmacology , vol.429 , Issue.1-3 , pp. 287-296
    • Evans, S.M.1    Whittle, B.J.R.2
  • 11
    • 0015511847 scopus 로고
    • Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of acetaminophen
    • R.J. Flower, and J.R. Vane Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of acetaminophen Nature 240 1972 410 411
    • (1972) Nature , vol.240 , pp. 410-411
    • Flower, R.J.1    Vane, J.R.2
  • 15
    • 77955887679 scopus 로고    scopus 로고
    • Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats
    • S. Ilic, I. Brcic, M. Mester, M. Filipovic, M. Sever, and R. Klicek Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats J Physiol Pharmacol 60 Suppl. 7 2009 107 114
    • (2009) J Physiol Pharmacol , vol.60 , Issue.SUPPL. 7 , pp. 107-114
    • Ilic, S.1    Brcic, I.2    Mester, M.3    Filipovic, M.4    Sever, M.5    Klicek, R.6
  • 16
    • 77955892601 scopus 로고    scopus 로고
    • High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736)
    • S. Ilic, D. Drmic, K. Zarkovic, D. Kolenc, M. Coric, and L. Brcic High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736) J Physiol Pharmacol 61 2010 241 250
    • (2010) J Physiol Pharmacol , vol.61 , pp. 241-250
    • Ilic, S.1    Drmic, D.2    Zarkovic, K.3    Kolenc, D.4    Coric, M.5    Brcic, L.6
  • 19
    • 52949096054 scopus 로고    scopus 로고
    • Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL 14736, Pliva), is effective in the healing of colocutaneous fistulas in rats: The role of NO-system
    • R. Klicek, M. Sever, B. Radic, D. Drmic, I. Kocman, and I. Zoricic Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL 14736, Pliva), is effective in the healing of colocutaneous fistulas in rats: the role of NO-system J Pharmacol Sci 108 2008 7 17
    • (2008) J Pharmacol Sci , vol.108 , pp. 7-17
    • Klicek, R.1    Sever, M.2    Radic, B.3    Drmic, D.4    Kocman, I.5    Zoricic, I.6
  • 20
    • 33744499697 scopus 로고    scopus 로고
    • Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation
    • DOI 10.1002/jor.20096
    • A. Krivic, T. Anic, S. Seiwerth, D. Huljev, and P. Sikiric Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: promoted tendon-to-bone healing and opposed corticosteroid aggravation J Orthop Res 24 2006 982 989 (Pubitemid 43804933)
    • (2006) Journal of Orthopaedic Research , vol.24 , Issue.5 , pp. 982-989
    • Krivic, A.1    Anic, T.2    Seiwerth, S.3    Huljev, D.4    Sikiric, P.5
  • 22
    • 0034104597 scopus 로고    scopus 로고
    • Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs
    • Y. Masubuchi, S. Yamada, and T. Horie Possible mechanisms of hepatocyte injury induced by diphenylamine and its structurally related NSAIDS J Pharmacol Exp Ther 292 2000 982 987 (Pubitemid 30136591)
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.292 , Issue.3 , pp. 982-987
    • Masubuchi, Y.1    Yamada, S.2    Horie, T.3
  • 23
    • 48549092425 scopus 로고    scopus 로고
    • Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat
    • T. Novinscak, L. Brcic, M. Staresinic, I. Jukic, B. Radic, and D. Pevec Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat Surg Today 38 2008 716 725
    • (2008) Surg Today , vol.38 , pp. 716-725
    • Novinscak, T.1    Brcic, L.2    Staresinic, M.3    Jukic, I.4    Radic, B.5    Pevec, D.6
  • 28
    • 0031760270 scopus 로고    scopus 로고
    • Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats
    • S. Seitz, and U.A. Boelsterli Diclofenac acyl glucoronide, a major biliary metabolite, is directly involved in small intestinal injury in rats Gastroenterology 115 1998 1476 1482 (Pubitemid 28545998)
    • (1998) Gastroenterology , vol.115 , Issue.6 , pp. 1476-1482
    • Seitz, S.1    Boelsterli, U.A.2
  • 29
    • 70149084307 scopus 로고    scopus 로고
    • Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats
    • M. Sever, R. Klicek, B. Radic, L. Brcic, I. Zoricic, and D. Drmic Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats Dig Dis Sci 54 2009 2070 2083
    • (2009) Dig Dis Sci , vol.54 , pp. 2070-2083
    • Sever, M.1    Klicek, R.2    Radic, B.3    Brcic, L.4    Zoricic, I.5    Drmic, D.6
  • 31
    • 0027373380 scopus 로고
    • Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin
    • P. Sikiric, S. Seiwerth, Z. Grabarevic, R. Rucman, M. Petek, and I. Rotkvic Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin Life Sci 53 1993 PL291 PL296
    • (1993) Life Sci , vol.53
    • Sikiric, P.1    Seiwerth, S.2    Grabarevic, Z.3    Rucman, R.4    Petek, M.5    Rotkvic, I.6
  • 38
    • 33845912425 scopus 로고    scopus 로고
    • Stable gastric pentadecapeptide BPC 157 in trials forinflammatory bowel disease (PL-10, PLD-116, Pliva, Croatia). Full and distended stomach, and vascular response
    • P. Sikiric, S. Seiwerth, L. Brcic, A.B. Blagaic, I. Zoricic, and M. Sever Stable gastric pentadecapeptide BPC 157 in trials forinflammatory bowel disease (PL-10, PLD-116, Pliva, Croatia). Full and distended stomach, and vascular response Inflammopharmacology 14 2006 1 8
    • (2006) Inflammopharmacology , vol.14 , pp. 1-8
    • Sikiric, P.1    Seiwerth, S.2    Brcic, L.3    Blagaic, A.B.4    Zoricic, I.5    Sever, M.6
  • 39
    • 77950882022 scopus 로고    scopus 로고
    • Revised Roberts cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator
    • P. Sikiric, S. Seiwerth, L. Brcic, M. Sever, R. Klicek, and B. Radic Revised Roberts cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator Curr Pharm Des 16 2010 1224 1234
    • (2010) Curr Pharm des , vol.16 , pp. 1224-1234
    • Sikiric, P.1    Seiwerth, S.2    Brcic, L.3    Sever, M.4    Klicek, R.5    Radic, B.6
  • 41
    • 58149301512 scopus 로고    scopus 로고
    • Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: Stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole
    • S. Skorjanec, Z. Dolovski, I. Kocman, L. Brcic, A. Blagaic Boban, and L. Batelja Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole Dig Dis Sci 54 2009 46 56
    • (2009) Dig Dis Sci , vol.54 , pp. 46-56
    • Skorjanec, S.1    Dolovski, Z.2    Kocman, I.3    Brcic, L.4    Blagaic Boban, A.5    Batelja, L.6
  • 44
    • 0034750281 scopus 로고    scopus 로고
    • NSAIDs inhibit the activation of egr-1 gene in microvascular endothelial cells. A key to inhibition of angiogenesis?
    • DOI 10.1016/S0928-4257(01)00051-1, PII S0928425701000511
    • I.L. Szabó, R. Pai, B. Soreghan, M.K. Jones, D. Baatar, and H. Kawanaka NSAIDs inhibit the activation of egr-1 gene in microvascular endothelial cells. A key to inhibition of angiogenesis? J Physiol Paris 95 2001 379 383 (Pubitemid 33020263)
    • (2001) Journal of Physiology Paris , vol.95 , Issue.1-6 , pp. 379-383
    • Szabo, I.L.1    Pai, R.2    Soreghan, B.3    Jones, M.K.4    Baatar, D.5    Kawanaka, H.6    Tarnawski, A.S.7
  • 45
    • 0034747922 scopus 로고    scopus 로고
    • Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs
    • DOI 10.1016/S0928-4257(01)00005-5, PII S0928425701000055
    • A. Tanaka, H. Araki, Y. Komoike, S. Hase, and K. Takeuchi Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs J Physiol Paris 95 2001 21 27 (Pubitemid 33020214)
    • (2001) Journal of Physiology Paris , vol.95 , Issue.1-6 , pp. 21-27
    • Tanaka, A.1    Araki, H.2    Komoike, Y.3    Hase, S.4    Takeuchi, K.5
  • 46
    • 0042591218 scopus 로고    scopus 로고
    • The metabolism of diclofenac-enzymology and toxicology perspectives
    • W. Tang The metabolism of diclofenac-enzymology and toxicology perspectives Curr Drug Metab 4 2003 319 329
    • (2003) Curr Drug Metab , vol.4 , pp. 319-329
    • Tang, W.1
  • 48
    • 7544224835 scopus 로고    scopus 로고
    • Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: α-Methyl-L-tryptophan autoradiographic measurements
    • DOI 10.1016/j.lfs.2004.08.010, PII S0024320504006812
    • Y. Tohyama, P. Sikiric, and M. Diksic Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements Life Sci 76 2004 345 357 (Pubitemid 39452915)
    • (2004) Life Sciences , vol.76 , Issue.3 , pp. 345-357
    • Tohyama, Y.1    Sikiric, P.2    Diksic, M.3
  • 50
    • 10444260480 scopus 로고    scopus 로고
    • The first nobel prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904
    • J.D. Wood The first Nobel prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904 Physiology 19 2004 326 330 (Pubitemid 39636079)
    • (2004) Physiology , Issue.6 , pp. 326-330
    • Wood, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.