Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 2, 2002, Pages 401-414

  Miki, Takashi ^a   Kori, Masakuni ^a   Mabuchi, Hiroshi ^a   Banno, Hiroshi ^a   Tozawa, Ryu ichi ^a   Nakamura, Masahira ^a   Itokawa, Shigekazu ^a   Sugiyama, Yasuo ^a   Yukimasa, Hidefumi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4,1 BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; ENZYME INHIBITOR; SQUALENE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATOM; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; HYPERCHOLESTEROLEMIA; IC 50; MARMOSET; NONHUMAN; OPTICAL RESOLUTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TEMPERATURE;

ADMINISTRATION, ORAL; ANIMALS; CALLITHRIX; CARCINOMA, HEPATOCELLULAR; CHOLESTEROL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; HUMANS; INHIBITORY CONCENTRATION 50; LIVER; MALE; OXAZEPINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036132554     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00290-5     Document Type: Article

References (20)

1. (Takeda) Eur. Patent, 567026
2. (Takeda) Eur. Patent, 645377
3. (Takeda) Eur. Patent, 645378
4. (Takeda) PCT Int. Appl. WO9521834