Mutations that probe the cooperative assembly of O6- alkylguanine-DNA alkyltransferase complexes

Biochemistry

Volumn 50, Issue 10, 2011, Pages 1590-1598

  Adams, Claire A ^a,b   Fried, Michael G ^a  

^a Center for Structural Biology   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENTS; ALKYLTRANSFERASE; CO-OPERATIVE ASSEMBLY; COOPERATIVITY; DNA BINDING; PROTEIN MOLECULES; PROTEIN-DNA INTERACTIONS; PROTEIN-PROTEIN INTERACTIONS; PROTEIN-PROTEIN INTERFACE; WILD-TYPE CELLS; WILD-TYPE PROTEINS;

AMINO ACIDS; COMPLEXATION; DNA; ESCHERICHIA COLI; MUTAGENS; NUCLEIC ACIDS; STOICHIOMETRY;

PROTEINS;

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; METHYLNITRONITROSOGUANIDINE;

ARTICLE; BINDING AFFINITY; CELL PROTECTION; CONTROLLED STUDY; DNA SEQUENCE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY; SUBSTITUTION REACTION; WILD TYPE;

DNA; HUMANS; MODELS, MOLECULAR; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 79952408590     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101970d     Document Type: Article

References (47)

1. 6 alkylation of dexoyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides Nature 223, 206-207
2. Snow, E. T. and Mitra, S. (1987) Do carcinogen-modified deoxynucleotide precursors contribute to cellular mutagenesis? Cancer Invest. 5, 119-125 (Pubitemid 17124472)
3. 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogens and therapeutic agents Cancer Res. 50, 6119-6129 (Pubitemid 20323662)
4. 6-Alkylguanine-DNA alkyltransferase: Role in carcinogenesis and chemotherapy BioEssays 24, 255-266 (Pubitemid 34248691)
5. Gerson, S. L. (2002) Clinical relevance of MGMT in the treatment of cancer J. Clin. Oncol. 20, 2388-2399 (Pubitemid 34441669)
6. 6-alkylguanine by alkyltransferases Mutat. Res. 462, 83-100 (Pubitemid 30190216)
7. Liu, L. and Gerson, S. L. (2006) Targeted modulation of MGMT: Clinical implications Clin. Cancer Res. 12, 328-331 (Pubitemid 43166117)
8. Ranson, M., Middleton, M. R., Bridgewater, J., Lee, S. M., Dawson, M., Jowle, D., Halbert, G., Waller, S., McGrath, H., Gumbrell, L., McElhinney, R. S., Donnelly, D., McMurry, T. B., and Margison, G. P. (2006) Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: Phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with Temozolomide in patients with advanced solid tumors Clin. Cancer Res. 12, 1577-1584
9. 6- methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity J. Clin. Oncol. 26, 4189-4199
10. 6-Methylguanine-DNA methyltransferase inactivation and chemotherapy Br. Med. Bull. 85, 17-33 (Pubitemid 351398290)
11. 6-alkylguanine-DNA alkyltransferase as a target for cancer chemotherapy. In DNA alterations in cancer: Genetic and epigenetic changes (Ehrlich, E. M., Ed.) pp 471 - 488, Eaton Publishing, Natick, MA.
12. 6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy DNA Repair 6, 1100-1115 (Pubitemid 47058393)
13. 6-alkylguanine-DNA alkyltransferases Mutat. Res. 233, 165-175
14. 6-Alkylguanine-DNA Alkyltransferase (AGT) with Short Single-Stranded DNAs J. Biol. Chem. 282, 3357-3366 (Pubitemid 47084307)
15. 6-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs Biochemistry 47, 13754-13763
16. Daniels, D. S., Woo, T. T., Luu, K. X., Noll, D. M., Clarke, N. D., Pegg, A. E., and Tainer, J. A. (2004) DNA binding and nucleotide flipping by the human DNA repair protein AGT Nat. Struct. Mol. Biol. 11, 714-720 (Pubitemid 39014496)
17. Duguid, E. M., Rice, P. A., and He, C. (2005) The Structure of the Human AGT Protein Bound to DNA and its Implications for Damage Detection J. Mol. Biol. 350, 657-666 (Pubitemid 40848665)
18. 6-alkylguanine-DNA alkyltransferase and DNA J. Mol. Biol. 389, 248-263
19. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs Nucleic Acids Res. 25, 3389-3402 (Pubitemid 27359211)
20. 6-alkylguanine-DNA alkyltransferase Prog. Nucleic Acid Res. Mol. Biol. 51, 167-223
21. Arakawa, T., Ejima, D., Tsumoto, K., Obeyama, N., Tanaka, Y., Kita, Y., and Timasheff, S. N. (2007) Suppression of protein interactions by arginine: A proposed mechanism of the arginine effects Biophys. Chem. 127, 1-8
22. 6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability J. Biol. Chem. 278, 7973-7980 (Pubitemid 36800535)
23. Maxam, A. and Gilbert, W. S. (1977) A new method for sequencing DNA Proc. Natl. Acad. Sci. U.S.A. 74, 560-565
24. McGhee, J. and von Hippel, P. H. (1974) Theoretical aspects of DNA-protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice J. Mol. Biol. 86, 469-489
25. Tsodikov, O. V., Holbrook, J. A., Shkel, I. A., and Record, M. T., Jr. (2001) Analytic binding isotherms describing competitive interactions of a protein ligand with specific and nonspecific sites on the same DNA oligomer Biophys. J. 81, 1960-1969 (Pubitemid 32917148)
26. Sreerama, N. and Woody, R. W. (2000) Estimation of protein secondary structure from circular dichroism spectra: Comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set Anal. Biochem. 287, 252-260 (Pubitemid 32006234)
27. Sreerama, N. and Woody, R. W. (2004) Computation and analysis of protein circular dichroism spectra Methods Enzymol. 383, 318-351 (Pubitemid 38401795)
28. Dam, J. and Schuck, P. (2004) Calculating sedimentation coefficient distributions by direct modeling of sedimentation velocity concentration profiles Methods Enzymol. 384, 185-212 (Pubitemid 38420481)
29. Schuck, P. (2000) Size distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling Biophys. J. 78, 1606-1619 (Pubitemid 30141584)
30. Laue, T. M., Shah, B. D., Ridgeway, T. M., and Pelletier, S. L. (1992) Computer-Aided Interpretation of Analytical Sedimentation Data For Proteins. In Analytical Ultracentrifugation in Biochemistry and Polymer Science (Harding, S. E., Rowe, A. J., and Horton, J. C., Eds.) pp 90 - 125, The Royal Society of Chemistry, Cambridge, England.
31. Crone, T. M., Kanugula, S., and Pegg, A. E. (1995) Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine Carcinogenesis 16, 1687-1692
32. 6-alkylguanine-DNA alkyltransferase Mutat. Res. 363, 15-25 (Pubitemid 26134903)
33. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227, 680-685
34. Burnette, W. N. (1981) "Western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A Anal. Biochem. 112, 195-203
35. Towbin, H., Staehelin, T., and Gordon, J. (1989) Immunoblotting in the clinical laboratory J. Clin. Chem. Clin. Biochem. 27, 495-501 (Pubitemid 19219375)
36. 6-benzylguanine Cancer Res. 53, 4750-4753 (Pubitemid 23326157)
37. Faham, S., Yang, D., Bare, E., Yohannan, S., Whitelegge, J. P., and Bowie, J. U. (2004) Side-chain contributions to membrane protein structure and stability J. Mol. Biol. 335, 297-305 (Pubitemid 37494980)
38. Hristova, K. and White, S. H. (2005) An experiment-based algorithm for predicting the partitioning of unfolded peptides into phosphatidylcholine bilayer interfaces Biochemistry 44, 12614-12619 (Pubitemid 41324352)
39. Strehlow, K. G. and Baldwin, R. L. (1989) Effect of the substitution Ala → Gly at each of five residue positions in the C-peptide helix Biochemistry 28, 2130-2133 (Pubitemid 19084440)
40. O'Neill, K. T. and Degrado, W. F. (1990) A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids Science 250, 646-651
41. 6- alkylguanine DNA alkyltransferase Protein Sci. 13, 301-305 (Pubitemid 38021163)
42. 6-methylguanine-DNA methyltransferase J. Mol. Biol. 231, 950-959 (Pubitemid 23209872)
43. 6-alkylguanine-DNA alkyltransferase Biochemistry 41, 8689-8697 (Pubitemid 34743309)
44. Yang, S. W. and Nash, H. A. (1995) Comparison of protein binding to DNA in vivo and in vitro: Defining an effective intracellular target EMBO J. 14, 6292-6300 (Pubitemid 26007315)
45. Blank, T. A. and Becker, P. B. (1995) Electrostatic Mechanism of Nucleosome Spacing J. Mol. Biol. 252, 305-313
46. Schalch, T., Duda, S., Sargent, D. F., and Richmond, T. J. (2005) X-ray structure of a tetranucleosome and its implications for the chromatin fibre Nature 436, 138-141 (Pubitemid 40966200)
47. Brown, P. H., Balbo, A., and Schuck, P. (2009) On the analysis of sedimentation velocity in the study of protein complexes Eur. Biophys. J. 38, 1079-1099