Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells

British Journal of Pharmacology

Volumn 162, Issue 7, 2011, Pages 1564-1576

  Lee, Mary Y K ^a   Li, Huiying ^a   Xiao, Yang ^b   Zhou, Zhiguang ^b   Xu, Aimin ^a   Vanhoutte, Paul M ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

A FABP; atherosclerosis; endothelial dysfunction; endothelium dependent relaxation; eNOS; nitric oxide

Indexed keywords

2 [2' (5 ETHYL 3,4 DIPHENYL 1H PYRAZOL 1 YL)BIPHENYL 3 YLOXY]ACETIC ACID; ACETYLCHOLINE; BMS 309403; BRIMONIDINE; CALCIMYCIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE INHIBITOR; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PERTUSSIS TOXIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERLIPOPROTEINEMIA TYPE 3; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; MUSCLE RELAXATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL;

ACETYLCHOLINE; ADIPOCYTES; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; AORTA; APOLIPOPROTEINS E; BIPHENYL COMPOUNDS; BLOOD GLUCOSE; CALCIMYCIN; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FATTY ACID-BINDING PROTEINS; FEMALE; HUMANS; INSULIN; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PYRAZOLES; VASODILATION;

EID: 79952386370     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01158.x     Document Type: Article

References (42)

1. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, et al. (2002). Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22: 1686-1691.
2. Crauwels HM, Van Hove CE, Holvoet P, Herman AG, Bult H, (2003). Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI. Cardiovasc Res 59: 189-199. (Pubitemid 36776385)
3. Flavahan NA, Shimokawa H, Vanhoutte PM, (1989). Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries. J Physiol 408: 549-560. (Pubitemid 19040037)
4. Fournet-Bourguignon MP, Castedo-Delrieu M, Bidouard JP, Leonce S, Saboureau D, Delescluse I, et al. (2000). Phenotypic and functional changes in regenerated porcine coronary endothelial cells: increased uptake of modified LDL and reduced production of NO. Circ Res 86: 854-861. (Pubitemid 30246982)
5. Fu Y, Luo N, Lopes-Virella MF, (2000). Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages. J Lipid Res 41: 2017-2023. (Pubitemid 32038997)
6. Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, et al. (2007). Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447: 959-965. (Pubitemid 46975747)
7. Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS, et al. (2008). Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest 118: 2640-2650. (Pubitemid 351949791)
8. Hans CP, Feng Y, Naura AS, Zerfaoui M, Rezk BM, Xia H, et al. (2009). Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress. Plos One 4: e7430.
9. Hoenig MR, Bianchi C, Rosenzweig A, Sellke FW, (2008). Decreased vascular repair and neovascularization with ageing: mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1. Curr Mol Med 8: 754-767.
10. Hui X, Li H, Zhou Z, Lam KS, Xiao Y, Wu D, et al. (2010). Adipocyte fatty acid binding protein mediates inflammatory responses in macrophages through a positive feedback loop involving c-Jun N-terminal kinases and activator protein-1. J Biol Chem 258: 10273-10282.
11. Kawashima S, (2004). Malfunction of vascular control in lifestyle-related diseases: endothelial nitric oxide (NO) synthase/NO system in atherosclerosis. J Pharmacol Sci 96: 411-419. (Pubitemid 40144061)
12. Kazemi MR, McDonald CM, Shigenaga JK, Grunfeld C, Feingold KR, (2005). Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists. Arterioscler Thromb Vasc Biol 25: 1220-1224. (Pubitemid 40776612)
13. Kennedy S, Fournet-Bourguignon MP, Breugnot C, Castedo-Delrieu M, Lesage L, Reure H, et al. (2003). Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL. J Vasc Res 40: 389-398. (Pubitemid 37188108)
14. Krusinová E, Pelikánová T, (2008). Fatty acid binding proteins in adipose tissue: a promising link between metabolic syndrome and atherosclerosis? Diabetes Res Clin Pract 82 (Suppl. 2): S127-S134.
15. Lee MYK, Tse HF, Siu CW, Zhu SG, Man RYK, Vanhoutte PM, (2007). Genomic changes in regenerated porcine coronary arterial endothelial cells. Arterioscler Thromb Vasc Biol 27: 2443-2449. (Pubitemid 350203962)
16. Libby P, (2007). Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev 65: S140-S146.
17. Llaverias G, Noé V, Peñuelas S, Vázquez-Carrera M, Sánchez RM, Laguna JC, et al. (2004). Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages. Biochem Biophys Res Commun 318: 265-274. (Pubitemid 38526275)
18. Lloréns S, de Mera RM, Pascual A, Prieto-Martín A, Mendizábal Y, de Cabo C, et al. (2007). The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging. Biogerontology 8: 663-672.
19. Makowski L, Hotamisligil GS, (2005). The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol 16: 543-548. (Pubitemid 41376904)
20. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, et al. (2001). Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nature Medicine 7: 699-705. (Pubitemid 32588026)
21. Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS, (2005). The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J Biol Chem 280: 12888-12895.
22. Moghadasian MH, McManus BM, Nguyen LB, Shefer S, Nadji M, Godin DV, et al. (2001). Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans. FASEB J 15: 2623-2630. (Pubitemid 33131089)
23. Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR, (2009). Nuclear factor-B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 119: 1284-1292.
24. Rodríguez-Mañas L, El-Assar M, Vallejo S, Lõpez-Dõriga P, Solís J, Petidier R, et al. (2009). Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell 8: 226-238.
25. Shimokawa H, Vanhoutte PM, (1988). Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation 78: 1421-1430. (Pubitemid 19004244)
26. Shimokawa H, Vanhoutte PM, (1989). Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ Res 64: 900-914. (Pubitemid 19117644)
27. Shimokawa H, Flavahan NA, Vanhoutte PM, (1989). Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a Pertussis toxin-sensitive G protein. Circ Res 65: 740-753. (Pubitemid 19226448)
28. Shimokawa H, Flavahan NA, Vanhoutte PM, (1991). Loss of endothelial Pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries. Circulation 83: 652-660.
29. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, et al. (2001). Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38: 274-279. (Pubitemid 34224757)
30. Tang EH, Vanhoutte PM, (2009). Prostanoids and reactive oxygen species: team players in endothelium-dependent contractions. Pharmacol Ther 122: 140-149.
31. Tang EH, Ku DD, Tipoe GL, Feletou M, Man RY, Vanhoutte PM, (2005). Endothelium-dependent contractions occur in the aorta of wild-type and COX2-/- knockout but not COX1-/- knockout mice. J Cardiovasc Pharmacol 46: 761-765. (Pubitemid 44378247)
32. Vanhoutte PM, Shimokawa H, (1989). Endothelium-derived relaxing factor and coronary vasospasm. Circulation 80: 1-9. (Pubitemid 19178632)
33. Vanhoutte PM, (2004). Endothelial function and dysfunction. Heart Metab 22: 5-10.
34. Vanhoutte PM, (2009). Endothelial dysfunction: the first step toward coronary arteriosclerosis. Circ J 73: 595-601.
35. Vanhoutte PM, Tang EH, (2008). Endothelium-dependent contractions:when a good guy turns bad! J Physiol 586: 5295-5304.
36. Wamhoff BR, Lynch KR, Macdonald TL, Owens GK, (2008). Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol 28: 1454-1461.
37. Wang Y, Huang Y, Lam KS, Li Y, Wong WT, Ye H, et al. (2009). Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res 82: 484-492.
38. Wellen KE, Hotamisligil GS, (2005). Inflammation, stress, and diabetes. J Clin Invest 115: 1111-1119. (Pubitemid 40629025)
39. Williams KJ, Scalia R, Mazany KD, Rodrigueza WV, Lefer AM, (2000). Rapid restoration of normal endothelial functions in genetically hyperlipidemic mice by a synthetic mediator of reverse lipid transport. Arterioscler Thromb Vasc Biol 20: 1033-1039. (Pubitemid 30207578)
40. Yeung DC, Xu A, Cheung CW, Wat NM, Yau MH, Fong CH, et al. (2007). serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis. Arterioscler Thromb Vasc Biol 27: 1796-1802. (Pubitemid 47207176)
41. Yeung DC, Xu A, Tso AW, Chow WS, Wat NM, Fong CH, et al. (2009). Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients. Diabetes Care 32: 132-134.
42. Yildiz O, (2007). Vascular smooth muscle and endothelial functions in aging. Ann N Y Acad Sci 1100: 353-360. (Pubitemid 47092672)