메뉴 건너뛰기




Volumn 25, Issue 2, 2011, Pages 163-171

Bridging the translation gap - new hopes, new challenges

Author keywords

Biomedical research; Phase zero trials; Translation gap

Indexed keywords

AWARENESS; FINANCIAL MANAGEMENT; HEALTH CARE POLICY; HUMAN; INTERPERSONAL COMMUNICATION; MEDICAL PRACTICE; MEDICAL RESEARCH; NATIONAL HEALTH ORGANIZATION; PRIORITY JOURNAL; PROFESSIONAL KNOWLEDGE; REVIEW; STANDARDIZATION; TRANSLATIONAL RESEARCH;

EID: 79952376280     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2010.00903.x     Document Type: Review
Times cited : (17)

References (26)
  • 1
    • 33846995628 scopus 로고    scopus 로고
    • Economics of new oncology drug development
    • DiMasi J.A., Grabowski H.G. Economics of new oncology drug development. J. Clin. Oncol. (2007) 25 209-216.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 209-216
    • Dimasi, J.A.1    Grabowski, H.G.2
  • 2
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I., Landis J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. (2004) 3 711-715.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 3
    • 4944242884 scopus 로고    scopus 로고
    • A vision for the National Cancer Program in the United States
    • von Eschenbach A.C. A vision for the National Cancer Program in the United States. Nat. Rev. Cancer (2004) 4 820-828.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 820-828
    • von Eschenbach, A.C.1
  • 4
    • 79952366413 scopus 로고    scopus 로고
    • US Department of Health and Human Services. Food and Drug Administration Innovation or stagnation: challenges and opportunity on the critical path to new medical products. US Department of Health and Human Services
    • US Department of Health and Human Services. Food and Drug Administration Innovation or stagnation: challenges and opportunity on the critical path to new medical products. US Department of Health and Human Services. (2004)
    • (2004)
  • 5
    • 34047177929 scopus 로고    scopus 로고
    • Biomarker qualification pilot process at the US Food and Drug Administration
    • Goodsaid F., Frueh F. Biomarker qualification pilot process at the US Food and Drug Administration. AAPS J. (2007) 9 E105-E108.
    • (2007) AAPS J. , vol.9
    • Goodsaid, F.1    Frueh, F.2
  • 6
    • 47349084016 scopus 로고    scopus 로고
    • Translational medicine: science or wishful thinking?
    • Wehling M. Translational medicine: science or wishful thinking? J Transl Med. (2008) 6 31.
    • (2008) J Transl Med. , vol.6 , pp. 31
    • Wehling, M.1
  • 7
    • 79952395015 scopus 로고    scopus 로고
    • US Department of Health and Human Services. Food and Drug Administration Guidance for industry, investigators, and reviewers: Exploratory IND studies. US Department of Health and Human Services. () ( ).
    • US Department of Health and Human Services. Food and Drug Administration Guidance for industry, investigators, and reviewers: Exploratory IND studies. US Department of Health and Human Services. (2006) ( ).
    • (2006)
  • 8
    • 33745406564 scopus 로고    scopus 로고
    • Slow start to Phase 0 as researchers debate value
    • Twombly R. Slow start to Phase 0 as researchers debate value. J. Natl Cancer Inst. (2006) 98 804-806.
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 804-806
    • Twombly, R.1
  • 9
    • 79952367573 scopus 로고    scopus 로고
    • NCI Phase 0 Working Group Inhibition of poly (ADP-ribose)polymerase (PARP) by ABT-888 in patients with advanced malignancies: results of a Phase 0 trial
    • 3518.
    • Kummar S, Kinders R, Gutierrez M et al. NCI Phase 0 Working Group Inhibition of poly (ADP-ribose)polymerase (PARP) by ABT-888 in patients with advanced malignancies: results of a Phase 0 trial. (2007) J. Clin. Oncol. 25 3518.
    • (2007) J. Clin. Oncol. , vol.25
    • Kummar, S.1    Kinders, R.2    Gutierrez, M.3
  • 10
    • 33947380240 scopus 로고    scopus 로고
    • Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology
    • Ratnam K., Low J.A. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. Clin. Cancer Res. (2007) 13 1383-1388.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1383-1388
    • Ratnam, K.1    Low, J.A.2
  • 11
    • 67149128618 scopus 로고    scopus 로고
    • Phase 0 trials for anticancer drug development
    • No authors listed].
    • [No authors listed]. Phase 0 trials for anticancer drug development. Nat. Rev. Drug Discov. (2009) 8 442.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 442
  • 12
    • 58849138367 scopus 로고    scopus 로고
    • Phase 0 clinical trials in oncology: a paradigm shift for early drug development?
    • Takimoto C.H. Phase 0 clinical trials in oncology: a paradigm shift for early drug development? Cancer Chemother. Pharmacol. (2009) 63 703-709.
    • (2009) Cancer Chemother. Pharmacol. , vol.63 , pp. 703-709
    • Takimoto, C.H.1
  • 13
    • 33846677129 scopus 로고    scopus 로고
    • Comparison of treatment effects between animal experiments and clinical trials: systematic review
    • Perel P., Roberts I., Sena E. et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ (2007) 334 197.
    • (2007) BMJ , vol.334 , pp. 197
    • Perel, P.1    Roberts, I.2    Sena, E.3
  • 14
    • 1442311168 scopus 로고    scopus 로고
    • Where is the evidence that animal research benefits humans?
    • Pound P., Ebrahim S., Sandercock P., Bracken M.B., Roberts I. Where is the evidence that animal research benefits humans? BMJ (2004) 328 514-517.
    • (2004) BMJ , vol.328 , pp. 514-517
    • Pound, P.1    Ebrahim, S.2    Sandercock, P.3    Bracken, M.B.4    Roberts, I.5
  • 15
    • 33749615999 scopus 로고    scopus 로고
    • Translation of research evidence from animals to humans
    • Hackam D.G., Redelmeier D.A. Translation of research evidence from animals to humans. JAMA (2006) 296 1731-1732.
    • (2006) JAMA , vol.296 , pp. 1731-1732
    • Hackam, D.G.1    Redelmeier, D.A.2
  • 16
    • 27644468268 scopus 로고    scopus 로고
    • How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men
    • Corpet D.E., Pierre F. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men Eur. J. Cancer (2005) 41 1911-1922.
    • (2005) Eur. J. Cancer , vol.41 , pp. 1911-1922
    • Corpet, D.E.1    Pierre, F.2
  • 17
    • 33846702343 scopus 로고    scopus 로고
    • Translating animal research into clinical benefit
    • Hackam D.G. Translating animal research into clinical benefit. BMJ (2007) 334 163-164.
    • (2007) BMJ , vol.334 , pp. 163-164
    • Hackam, D.G.1
  • 18
    • 0038616401 scopus 로고    scopus 로고
    • Emergency medicine animal research: does use of randomization and blinding affect the results?
    • Bebarta V., Luyten D., Heard K. Emergency medicine animal research: does use of randomization and blinding affect the results? Acad. Emerg. Med. (2003) 10 684-687.
    • (2003) Acad. Emerg. Med. , vol.10 , pp. 684-687
    • Bebarta, V.1    Luyten, D.2    Heard, K.3
  • 19
    • 0037160695 scopus 로고    scopus 로고
    • Does animal experimentation inform human health care? Observations from a systematic review of international animal experiments on fluid resuscitation
    • Roberts I., Kwan I., Evans P., Haig S. Does animal experimentation inform human health care? Observations from a systematic review of international animal experiments on fluid resuscitation BMJ (2002) 324 474-476.
    • (2002) BMJ , vol.324 , pp. 474-476
    • Roberts, I.1    Kwan, I.2    Evans, P.3    Haig, S.4
  • 20
    • 70350303591 scopus 로고    scopus 로고
    • Effects of NXY-059 in experimental stroke: an individual animal meta-analysis
    • Bath P.M.W., Gray L.J., Bath A.J.G. et al. Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br. J. Pharmacol. (2009) 157, 1157-1171.
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 1157-1171
    • Bath, P.M.W.1    Gray, L.J.2    Bath, A.J.G.3
  • 21
    • 34547795720 scopus 로고    scopus 로고
    • NXY-059 for the treatment of acute ischemic stroke
    • Shuaib A., Lees K.R., Lyden P. et al. NXY-059 for the treatment of acute ischemic stroke. N. Engl. J. Med. (2007) 357 562-571.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 562-571
    • Shuaib, A.1    Lees, K.R.2    Lyden, P.3
  • 22
    • 54049103993 scopus 로고    scopus 로고
    • Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality
    • Macleod M.R., van der Worp H.B., Sena E.S., Howells D.W., Dirnagl U., Donnan G.A. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke (2008) 39 2824-2829.
    • (2008) Stroke , vol.39 , pp. 2824-2829
    • Macleod, M.R.1    van der Worp, H.B.2    Sena, E.S.3    Howells, D.W.4    Dirnagl, U.5    Donnan, G.A.6
  • 23
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • Stroke Therapy Academic Industry Roundtable.
    • Stroke Therapy Academic Industry Roundtable. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke (1999) 30 2752-2758.
    • (1999) Stroke , vol.30 , pp. 2752-2758
  • 24
    • 53249111808 scopus 로고    scopus 로고
    • The Translational Research Working Group developmental pathways: introduction and overview
    • Hawk E.T., Matrisian L.M., Nelson W.G. et al. The Translational Research Working Group developmental pathways: introduction and overview. Clin. Cancer Res. (2008) 14, 5664-5671.
    • (2008) Clin. Cancer Res , vol.14 , pp. 5664-5671
    • Hawk, E.T.1    Matrisian, L.M.2    Nelson, W.G.3
  • 25
    • 67650069258 scopus 로고    scopus 로고
    • Assessing the translatability of drug projects: what needs to be scored to predict success?
    • Wehling M. Assessing the translatability of drug projects: what needs to be scored to predict success? Nat. Rev. Drug Discov. (2009) 8 541-546.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 541-546
    • Wehling, M.1
  • 26
    • 33645388385 scopus 로고    scopus 로고
    • Translational medicine: can it really facilitate the transition of research "from bench to bedside"?
    • Wehling M. Translational medicine: can it really facilitate the transition of research "from bench to bedside"? Eur. J. Clin. Pharmacol. (2006) 62 91-95.
    • (2006) Eur. J. Clin. Pharmacol. , vol.62 , pp. 91-95
    • Wehling, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.