Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection

Journal of Bacteriology

Volumn 193, Issue 6, 2011, Pages 1473-1476

  Yang, Xinxin ^a,c   Gao, Jin ^a,d   Smith, Issar ^b   Dubnau, Eugenie ^b   Sampson, Nicole S ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; CARBON SOURCE; CONTROLLED STUDY; GENE MUTATION; GENETIC CODE; GUINEA PIG; MACROPHAGE; MICROBIAL METABOLISM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

ANIMALS; BACTERIAL PROTEINS; CHOLESTEROL; DISEASE MODELS, ANIMAL; GENE DELETION; GUINEA PIGS; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; VIRULENCE; VIRULENCE FACTORS;

CAVIA; MYCOBACTERIUM TUBERCULOSIS;

EID: 79952371372     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.01210-10     Document Type: Article

References (27)

1. Belisle, J. T., L. Pascopella, J. M. Inamine, P. J. Brennan, and W. R. Jacobs, Jr. 1991. Isolation and expression of a gene cluster responsible for biosynthesis of the glycopeptidolipid antigens of Mycobacterium avium. J. Bacteriol. 173:6991-6997.
2. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917.
3. Boshoff, H. I., and C. E. Barry. 2005. A low-carb diet for a high-octane pathogen. Nat. Med. 11:599-600.
4. Brzostek, A., B. Dziadek, A. Rumijowska-Galewicz, J. Pawelczyk, and J. Dziadek. 2007. Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis. FEMS Lett. 275:106-112.
5. Brzostek, A., J. Pawelczyk, A. Rumijowska-Galewicz, B. Dziadek, and J. Dziadek. 2009. Mycobacterium tuberculosis is able to accumulate and utilize cholesterol. J. Bacteriol. 191:6584-6591.
6. Chang, J. C., et al. 2009. igr genes and Mycobacterium tuberculosis cholesterol metabolism. J. Bacteriol. 191:5232-5239.
7. Chiang, Y. R., et al. 2008. Study of anoxic and oxic cholesterol metabolism by Sterolibacterium denitrificans. J. Bacteriol. 190:905-914.
8. de Carvalho, L. P., et al. 2010. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chem. Biol. 17:1122-1131.
9. Donova, M. V. 2007. Transformation of steroids by actinobacteria: a review. Appl. Biochem. Microbiol. 43:1-14.
10. Horinouchi, S., H. Ishizuka, and T. Beppu. 1991. Cloning, nucleotide sequence, and transcriptional analysis of the NAD(P)-dependent cholesterol dehydrogenase gene from a Nocardia sp. and its hyperexpression in Streptomyces spp. Appl. Environ. Microbiol. 57:1386-1393.
11. Jain, M., et al. 2007. Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proc. Natl. Acad. Sci. U. S. A. 104:5133-5138.
12. Kishi, K., Y. Watazu, Y. Katayama, and H. Okabe. 2000. The characteristics and applications of recombinant cholesterol dehydrogenase. Biosci. Biotechnol. Biochem. 64:1352-1358.
13. Kreit, J., and N. S. Sampson. 2009. Cholesterol oxidase: physiological functions. FEBS J. 276:6844-6856.
14. Moller, M., E. de Wit, and E. G. Hoal. 2010. Past, present and future directions in human genetic susceptibility to tuberculosis. FEMS Immunol. Med. Microbiol. 58:3-26.
15. Munoz-Elias, E. J., and J. D. McKinney. 2005. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat. Med. 11:638-644.
16. Nesbitt, N., et al. 2010. A thiolase of M. tuberculosis is required for virulence and for production of androstenedione and androstadienedione from cholesterol. Infect. Immun. 78:275-282.
17. Ouellet, H., et al. 2010. Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. Mol. Microbiol. 77:730-742.
18. Pandey, A. K., and C. M. Sassetti. 2008. Mycobacterial persistence requires the utilization of host cholesterol. Proc. Natl. Acad. Sci. U. S. A. 105:4376-4380.
19. Rosłoniec, K. Z., et al. 2010. Cytochrome P450 125 (CYP125) catalyzes C26-hydroxylation to initiate sterol side chain degradation in Rhodococcus jostii RHA1. Mol. Microbiol. 74:1031-1043.
20. Sampson, N. S., and A. Vrielink. 2003. Cholesterol oxidases: a study of nature's approach to protein design. Acc. Chem. Res. 36:713-722.
21. Segal, W., and H. Bloch. 1956. Biochemical differentiation of Mycobacterium tuberculosis grown in vivo and in vitro. J. Bacteriol. 72:132-151.
22. Sonden, B., et al. 2005. Gap, a mycobacterial specific integral membrane protein, is required for glycolipid transport to the cell surface. Mol. Microbiol. 58:426-440.
23. Tsuchiya, S., et al. 1982. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res. 42:1530-1536. (Pubitemid 12148801)
24. Van der Geize, R., et al. 2007. A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc. Natl. Acad. Sci. U. S. A. 104:1947-1952.
25. Yam, K. C., et al. 2009. Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. PLoS Pathog. 5:e1000344.
26. Yang, X., E. Dubnau, I. Smith, and N. S. Sampson. 2007. Rv1106c from Mycobacterium tuberculosis is a 3′-hydroxysteroid dehydrogenase. Biochemistry 46:9058-9067.
27. Yang, X., N. M. Nesbitt, E. Dubnau, I. Smith, and N. S. Sampson. 2009. Cholesterol metabolism increases the metabolic pool of propionate in Mycobacterium tuberculosis. Biochemistry 48:3819-3821.