On the venom system of centipedes (Chilopoda), a neglected group of venomous animals

Toxicon

Volumn 57, Issue 4, 2011, Pages 512-524

  Undheim, Eivind A B ^a   King, Glenn F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Centipedes; Chilopoda; Venom; Venom gland

Indexed keywords

ARTHROPOD VENOM; CARDIOTOXIN; CENTIPEDE VENOM; CYTOTOXIN; ESTERASE; HYALURONIDASE; MYOTOXIN; NEUROTOXIN; PROTEINASE; SEROTONIN; TOXIN; UNCLASSIFIED DRUG;

ANIMAL ANATOMY; ARTHROPOD; CENTIPEDE; CHEMICAL COMPOSITION; ENVENOMATION; FUNCTIONAL MORPHOLOGY; HUMAN; NONHUMAN; PHYLOGENY; POISONOUS ANIMAL; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; TOXIN ANALYSIS; VENOM GLAND;

ANIMALS; ARTHROPOD VENOMS; ARTHROPODS; EXOCRINE GLANDS; INSECT PROTEINS; METALLOPROTEASES; NEUROTOXINS;

ANIMALIA; ARTHROPODA; CHILOPODA;

EID: 79952363866     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.01.004     Document Type: Review

References (129)

1. Aird S.D. Ophidian envenomation strategies and the role of purines. Toxicon 2002, 40:335-393.
2. Anderson L.I., Trewin N.H. An early Devonian arthropod fauna from the Windyfield cherts, Aberdeenshire, Scotland. Palaeontology 2003, 46:467-509.
3. Antoniazzi M.M., Pedroso C.M., Knysak I., Martins R., Guizze S.P.G., Jared C., Barbaro K.C. Comparative morphological study of the venom glands of the centipede Cryptops iheringi, Otostigmus pradoi and Scolopendra viridicornis. Toxicon 2009, 53:367-374.
4. Bücherl W. Açâo do veneno dos Escolopendromorfos do Brasil sobre alguns animais de laboratorio. Mem. Inst. Butantan 1946, 19:181-197.
5. Baerg W.J. The effect of the venom of some supposedly poisonous arthropods. Ann. Entomol. Soc. Am. 1924, 17:343-352.
6. Baerg W.J. The effect of the venom of some supposedly poisonous arthropods of the canal zone. Ann. Entomol. Soc. Am. 1925, 18:471-478.
7. Balit C.R., Harvey M.S., Waldock J.M., Isbister G.K. Prospective study of centipede bites in Australia. Clin. Toxicol 2004, 42:41-48.
8. Bhagirath T., Chingtham B., Mohen Y. Venom of a hill centipede Scolopendra viridicornis inhibits growth of human breast tumor in mice. Indian J. Pharmacol 2006, 38:291.
9. Blay E.R. Treatment of centipede bites. Br. Med. J. 1955, 2:1619.
10. Bonato L., Barber A., Minelli A. The European centipedes hitherto referred to Eurygeophilus, Mesogeophilus, and Chalandea (Chilopoda, Geophilomorpha): taxonomy, distribution, and geographical variation in segment number. J. Nat. Hist. 2006, 40:415-438.
11. Briot A. Sur les venin des Scolopendres. C. R. Seances Soc. Biol. Fil 1904, 57:476-477.
12. Bush S.P., King B.O., Noris R.L., Stockwell S.A. Centipede envenomation. Wilderness Environ. Med. 2001, 12:93-99.
13. Calvete J.J., Moreno-Murciano M.P., Theakston R.D.G., Kisiel D.G., Marcinkiewicz C. Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering. Biochem. J. 2003, 372:725-734.
14. Carpenter C.C., Gillingham J.C. Giant centipede (Scolopendra alternans) attacks marine toad (Bufo marinus). Caribb. J. Sci. 1984, 20:71-72.
15. Chahl L.A., Kirk E.J. Toxins which produce pain. Pain 1975, 1:3-49.
16. Chao J.L., Chang H.W. Variation of the poison duct in Chilopoda centipedes from Taiwan. Nor. J. Entomol. 2006, 53:139-151.
17. Chaou C.-H., Chen C.-K., Chen J.-C., Chiu T.-F., Lin C.-C. Comparisons of ice packs, hot water immersion, and analgesia injection for the treatment of centipede envenomations in Taiwan. Clin. Toxicol. 2009, 47:659-662.
18. Clark D.B. A centipede preying on a nestling Rice Rat (Oryzomys bauri). J. Mammology 1979, 60:654.
19. Coffin S.W. Notes on a case of centipede bite. Lancet 1919, 193:1117-1118.
20. Cohen E., Quistad G.B. Cytotoxic effects of arthropod venoms on various cultured cells. Toxicon 1998, 36:353-358.
21. Cornwall J.W. Some centipedes and their venom. Indian J. Med. Res. 1916, 3:541-557.
22. Crabill R.E.J. Concerning a new genus, Dinocryptops, and the nomenclatorial status of Otocryptops and Scolopocryptops (Chilopoda: Scolopendromorpha: Cryptopidae). Entomol. News 1953, 64:96.
23. Crabill R.E.J. A new American genus of cryptopid centipede, with an annotated key to the scolopendromorph genera from America north of Mexico. Proc. United States Natl. Mus 1960, 111:1-15.
24. Dass C.M.S., Jangi B.S. Ultrastructural organization of the poison gland of the centipede Scolopendra morsitans Linn. Indian J. Exp. Biol. 1978, 16:748-757.
25. Dhananjaya B.L., D'Souza C.J.M. The pharmacological role of nucleotidases in snake venoms. Cell Biochem. Funct 2010, 28:171-177.
26. Duboscq O. Recherches sur les chilopodes. Arch. Zool. Exp. Gen 1898, 6:481-650.
27. Dunlop J.A. Geological history and phylogeny of Chelicerata. Arthropod Struct. Dev. 2010, 39:124-142.
28. Easterla D.A. Giant desert centipede preys upon snake. Southwest. Nat. 1975, 20:411.
29. Edgecombe G.D., Barrow L. A new genus of scutigerid centipedes (Chilopoda) from Western Australia, with new characters for morphological phylogenetics of Scutigeromorpha. Zootaxa 2007, 1409:23-50.
30. Edgecombe G.D., Giribet G. Adding mitochondrial sequence data (16S rRNA and cytochrome c oxidase subunit I) to the phylogeny of centipedes (Myriapoda: Chilopoda): an analysis of morphology and four molecular loci. J. Zoolog. Syst. Evol. Res. 2004, 42:89-134.
31. Edgecombe G.D., Giribet G. Evolutionary biology of centipedes (Myriapoda: Chilopoda). Annu. Rev. Entomol. 2007, 52:151.
32. Edgecombe G., Giribet G. A New Zealand species of the trans-Tasman centipede order Craterostigmomorpha (Arthropoda: Chilopoda) corroborated by molecular evidence. Invertebr. Syst 2008, 22:1-15.
33. Edgecombe G.D., Koch M. Phylogeny of scolopendromorph centipedes (Chilopoda): morphological analysis featuring characters from the peristomatic area. Cladistics 2008, 24:872-901.
34. Fletcher J.E., Hubert M., Wieland S.J., Gong Q.-H., Jiang M.-S. Similarities and differences in mechanisms of cardiotoxins, melittin and other myotoxins. Toxicon 1996, 34:1301-1311.
35. Foddai D., Minelli A. A troglomorphic geophilomorph centipede from southern France (Chilopoda: Geophilomorpha: Geophilidae). J. Nat. Hist. 1999, 33:267-287.
36. Foddai D., Bonato L., Pereira L.A., Minelli A. Phylogeny and systematics of the Arrupinae (Chilopoda: Geophilomorpha: Mecistocephalidae) with the description of a new dwarfed species. J. Nat. Hist. 2003, 37:1247-1267.
37. Forti L.R., Fischer H.Z., Encarnação L.C. Treefrog Dendropsophus elegans (Wied-Neuwied, 1824)(Anura: Hylidae) as a meal to Otostigmus tibialis Brölemann, 1902 (Chilopoda: Scolopendridae) in the Tropical Rainforest in southeastern Brazil. Braz. J. Biol. 2007, 67:583-584.
38. Friedman I.S., Phelps R.G., Baral J., Sapadin A.N. Wells' syndrome triggered by centipede bite. Int. J. Dermatol. 1998, 37:602-605.
39. Fry B.G. From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins. Genome Res. 2005, 15:403-420.
40. Girish K.S., Shashidharamurthy R., Nagaraju S., Gowda T.V., Kemparaju K. Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom. Biochimie 2004, 86:193-202.
41. Gomes A., Datta A., Sarangi B., Kar P.K., Lahiri S.C. Occurrence of histamine and histamine release by centipede venom. Indian J. Med. Res. 1982, 76:888-891.
42. Gomes A., Datta A., Sarangi B., Kar P.K., Lahiri S.C. Pharmacodynamics of venom of the centipede Scolopendra subspinipes dehaani Brandt. Indian J. Exp. Biol. 1982, 20:615-618.
43. Gomes A., Datta A., Sarangi B., Kar P.K., Lahiri S.C. Isolation, purification and pharmacodynamics of a toxin from the venom of the centipede Scolopendra subspinipes dehaani Brandt. Indian J. Exp. Biol. 1983, 21:203-207.
44. González-Morales L., Diego-GarcÌa E., Segovia L., Gutiérrez M.d.C., Possani L.D. Venom from the centipede Scolopendra viridis say: purification, gene cloning and phylogenetic analysis of a phospholipase A2. Toxicon 2009, 54:8-15.
45. Gutiérrez J.M., Lomonte B. Phospholipase A2 myotoxins from Bothrops snake venoms. Toxicon 1995, 33:1405-1424.
46. Gutiérrez J.M., Rucavado A. Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage. Biochimie 2000, 82:841-850.
47. Gutiérrez M.d.C., Abarca C., Possani L.D. A toxic fraction from scolopendra venom increases the basal release of neurotransmitters in the ventral ganglia of crustaceans. Comp. Biochem. Physiol. C Toxicol. Pharmacol 2003, 135:205-214.
48. Hamza L., Girardi T., Castelli S., Gargioli C., Cannata S., Patamia M., Luly P., Laraba-Djebari F., Petruzzelli R., Rufini S. Isolation and characterization of a myotoxin from the venom of Macrovipera lebetina transmediterranea. Toxicon 2010, 56:381-390.
49. Harada K., Asa K., Imachi T., Yamaguchi Y., Yoshida K. Centipede inflicted postmortem injury. J. Forensic Sci. 1999, 44:849-850.
50. Hasan S., Hassan K. Proteinuria associated with centipede bite. Pediatr. Nephrol. 2005, 20:550-551.
51. Heitz J.R., Norment B.R. Characteristics of an alkaline phosphatase activity in brown recluse venom. Toxicon 1974, 12:181-187.
52. Hilken G., Rosenberg J., Brockmann C. Ultrastructure of the epidermal maxilla II-gland of Scutigera coleoptrata (Chilopoda, Notostigmophora) and the ground pattern of epidermal gland organs in Myriapoda. J. Morphol. 2005, 264:53-61.
53. Hjelle J.T. Anatomy and morphology. The Biology of Scorpions 1990, 54-56. Stanford University Press, Stanford. G.A. Polis (Ed.).
54. Hoffman R.L., Pereira L.A. Systematics and biogeography of Marsikomerus Attems, 1938, a misunderstood genus of centipedes (Geophilomorpha: Schendylidae). Insecta Mundi 1991, 5:45-60.
55. Hoyle, C.H.V., 2011. Evolution of neuronal signalling: Transmitters and receptors. Auton. Neurosci., in press, doi:10.1016/j.autneu.2010.05.007.
56. Jangi B.S., Dass C.M.S. Chemoreceptive function of the poison fang in the centipede Scolopendra morsitans L. Indian J. Exp. Biol. 1977, 15:803-804.
57. Jarrar B.M. Morphology, histology and histochemistry of the venom apparatus of the centipede, Scolopendra valida (Chilopoda, Scolopendridae). Int. J. Morphol. 2010, 28:19-25.
58. Kass L., Batsakis J.G. Cytochemistry of esterases. Crit. Rev. Clin. Lab. Sci. 1979, 10:205-223.
59. Knysak I., Martins R., Bertim C.R. Epidemiological aspects of centipede (Scolopendromorphae: Chilopoda) bites registered in greater S. Paulo, SP, Brazil. Rev. Saude Publica 1998, 32:514-518.
60. Koch M., Pärschke S., Edgecombe G.D. Phylogenetic implications of gizzard morphology in scolopendromorph centipedes (Chilopoda). Zool. Scr. 2009, 38:269-288.
61. Kuhn-Nentwig L. Antimicrobial and cytolytic peptides of venomous arthropods. Cell. Mol. Life Sci. 2003, 60:2651-2668.
62. Kuhn-Nentwig L., Schaller J., Nentwig W. Biochemistry, toxicology and ecology of the venom of the spider Cupiennius salei (Ctenidae). Toxicon 2004, 43:543-553.
63. Langley R.L. Animal-Related fatalities in the United States - An Update. Wilderness Environ. Med 2005, 16:67-74.
64. Langley R.L., Morrow W.E. Deaths resulting from animal attacks in the United States. Wilderness Environ. Med 1997, 8:8-16.
65. Lee S., Lynch K.R. Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). Biochem. J. 2005, 391:317-323.
66. Lewis J.G.E. The Biology of Centipedes 1981, Cambridge University Press, Cambridge.
67. Lewis J.G.E. The scolopendromorph centipedes of Mauritius and Rodrigues and their adjacent islets (Chilopoda: Scolopendromorpha). J. Nat. Hist. 2002, 36:79-106.
68. Lewis J.G.E., Daszak P., Jones C.G., Cottingham J.D., Wenman E., Maljkovic A. Field observations on three scolopendrid centipedes from Mauritius and Rodrigues (Indian Ocean) (Chilopoda: Scolopendromorpha). Int. J. Myriapodol 2010, 3:123-137.
69. Lima P.R.d., Brochetto-Braga M.R. Hymenoptera venom review focusing on Apis mellifera. J. Venom. Anim. Toxins Incl. Trop. Dis. 2003, 9:149-162.
70. Lin T.J., Yang C.C., Yang G.Y., Ger J., Tsai W.J., Deng J.F. Features of centipede bites in Taiwan. Trop. Geogr. Med. 1995, 47:300.
71. Liu T., Bai Z.-T., Pang X.-Y., Chai Z.-F., Jiang F., Ji Y.-H. Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom. Eur. J. Pharmacol. 2007, 575:46-56.
72. Logan J.L., Ogden D.A. Rhabdomyolysis and acute renal failure following the bite of the giant desert centipede Scolopendra heros. West. J. Med. 1985, 142:549.
73. Lomonte B., Angulo Y., Calderón L. An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action. Toxicon 2003, 42:885-901.
74. Long-Rowe K.O., Burnett J.W. Characteristics of hyaluronidase and hemolytic activity in fishing tentacle nematocyst venom of Chrysaora quinquecirrha. Toxicon 1994, 32:165-174.
75. Ménez A., Zimmerman K., Zimmerman S., Heatwole H. Venom apparatus and toxicity of the centipede Ethmostigmus rubripes (Chilopoda, Scolopendridae). J. Morphol. 1990, 206:303-312.
76. Ma Y., Zhao R., He Y., Li S., Liu J., Wu Y., Cao Z., Li W. Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: Implication for the evolution of the scorpion venom arsenal. BMC Genomics 2009, 10:290.
77. Malta M.B., Lira M.S., Soares S.L., Rocha G.C., Knysak I., Martins R., Guizze S.P.G., Santoro M.L., Barbaro K.C. Toxic activities of Brazilian centipede venoms. Toxicon 2008, 52:255-263.
78. Marsh F. Centipede bites. Br. Med. J. 1957, 2:825.
79. Matsui T., Fujimura Y., Titani K. Snake venom proteases affecting hemostasis and thrombosis. Biochim. Biophys. Acta - Prot. Struct. Mol. Enzymol 2000, 1477:146-156.
80. McKeown K.C. Centipedes and centipede bites. Aust. Mus. Mag 1930, 4:59-60.
81. Mebs D., Ehrenfeld M., Samejima Y. Local necrotizing effect of snake venoms on skin and muscle: relationship to serum creatine kinase. Toxicon 1983, 21:393-404.
82. Medeiros C.R., Susaki T.T., Knysak I., Cardoso J.L.C., Málaque C.M.S., Fan H.W., Santoro M.L., França F.O.S., Barbaro K.C. Epidemiologic and clinical survey of victims of centipede stings admitted to Hospital Vital Brazil (São Paulo, Brazil). Toxicon 2008, 52:606-610.
83. Minelli A. Secretions of centipedes. Handbook of Experimental Pharmacology: Arthropod Venoms 1978, Springer-Verlag, Berlin. S. Bettini (Ed.).
84. Mohamed A.H., Zaid E., El-Beih N.M., Abd El-Aal A. Effects of an extract from the centipede Scolopendra morsitans on intestine, uterus and heart contractions and on blod glucose and liver and muscle glycogen levels. Toxicon 1980, 18:581-589.
85. Mohamed A.H., Abu-Sinna G., El-Shabaka H.A., Abd El-Aal A. Proteins, lipids, lipoproteins and some enzyme characterizations of the venom extract from the centipede Scolopendra morsitans. Toxicon 1983, 21:371-377.
86. Mohri S., Sugiyama A., Saito K., Nakajima H. Centipede bites in Japan. Cutis 1991, 47:189.
87. Molinari J., Gutierrez E.E., De Ascencao A.A., Nassar J.M., Arends A., Marquez R.J. Predation by giant centipedes, Scolopendra gigantea, on three species of bats in a Venezuelan cave. Caribb. J. Sci. 2005, 41:340-346.
88. Mumcuoglu K.Y., Leibovici V. Centipede (Scolopendra) bite: a case report. Isr. J. Med. Sci. 1989, 25:47.
89. Murienne J., Edgecombe G.D., Giribet G. Including secondary structure, fossils and molecular dating in the centipede tree of life. Mol. Phylogenet. Evol. 2010, 57:301-313.
90. Nagaraju S., Mahadeswaraswamy Y.H., Girish K.S., Kemparaju K. Venom from spiders of the genus Hippasa: biochemical and pharmacological studies. Comp. Biochem. Physiol. C Toxicol. Pharmacol 2006, 144:1-9.
91. Nagaraju S., Girish K.S., Fox J.W., Kemparaju K. " Partitagin" a hemorrhagic metalloprotease from Hippasa partita spider venom: role in tissue necrosis. Biochimie 2007, 89:1322-1331.
92. Nagpal N., Kanwar U. The poison gland in the centipede Otostigmus ceylonicus; Morphology and cytochemistry. Toxicon 1981, 19:898-902.
93. Noguchi K., Herr D., Mutoh T., Chun J. Lysophosphatidic acid (LPA) and its receptors. Curr. Opin. Pharmacol. 2009, 9:15-23.
94. Oguiura N., Boni-Mitake M., R·dis-Baptista G. New view on crotamine, a small basic polypeptide myotoxin from South American rattlesnake venom. Toxicon 2005, 46:363-370.
95. Ozsarac M., Karcioglu O., Ayrik C., Somuncu F., Gumrukcu S. Acute coronary ischemia following centipede envenomation: case report and review of the literature. Wilderness Environ. Med 2004, 15:109-112.
96. Peng K., Kong Y., Zhai L., Wu X., Jia P., Liu J., Yu H. Two novel antimicrobial peptides from centipede venoms. Toxicon 2009, 55:274-279.
97. Pereira L.A., Uliana M., Minelli A. Geophilomorph centipedes (Chilopoda) from termite mounds in the northern Pantanal wetland of Mato Grosso, Brazil. Stud. Neotrop. Fauna Environ. 2007, 42:33-48.
98. Pineda E.V. A fatal case of centipede bite. J. Philippine Is. Med. Assoc. 1923, 3:59-63.
99. Quistad G.B., Dennis P.A., Skinner W.S. Insecticidal activity of spider (Araneae), centipede (Chilopoda), scorpion (Scorpionidae), and snake (Serpentes) venoms. J. Econ. Entomol. 1992, 85:33-39.
100. Rates B., Bemquerer M.P., Richardson M., Borges M.H., Morales R.A.V., De Lima M.E., Pimenta A. Venomic analyses of Scolopendra viridicornis nigra and Scolopendra angulata (Centipede, Scolopendromorpha): shedding light on venoms from a neglected group. Toxicon 2007, 49:810-826.
101. Remington C.L. The bite and habits of a giant centipede (Scolopendra subspinipes) in the Philippine Islands. Am. J. Trop. Med. Hyg 1950, 1:453.
102. Rodrigues M.C.A., Guimarães L.H.S., Liberato J.L., Polizeli M.d.L.T.d.M., dos Santos W.F. Acid and alkaline phosphatase activities of a fraction isolated from Parawixia bistriata spider venom. Toxicon 2006, 47:854-858.
103. Rosenberg J., Hilken G. Fine structural organization of the poison gland of Lithobius forficatus (Chilopoda, Lithobiomorpha). Nor. J. Entomol. 2006, 53:119-127.
104. Rouvin B., Seck M., N'diaye M., Diatta B., Saissy J.M. Morsure de scolopendre chez une drépanocytaire hétérozygote au Sénégal. Med. Trop. 2008, 68:647-648.
105. Said E. On the peptidases and esterases in the venom of Buthus quinquestriatus and Scolopendra morsitans. Proc. Egypt. Acad. Sci. 1958, 13:76-84.
106. Schaloske R.H., Dennis E.A. The phospholipase A2 superfamily and its group numbering system. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2006, 1761:1246-1259.
107. Serinken M., Erdur B., Sener S., Kabay B., Cevik A. A case of mortal necrotizing fasciitis of the trunk resulting from a centipede (Scolopendra moritans) bssite. Internet J. Emerg. Med 2005, 2:1-8.
108. Servent D., Fruchart-Gaillard C. Muscarinic toxins: tools for the study of the pharmacological and functional properties of muscarinic receptors. J. Neurochem. 2009, 1193-1202.
109. Shear W.A., Edgecombe G.D. The geological record and phylogeny of the Myriapoda. Arthropod Struct. Dev. 2009, 39:174-190.
110. Snodgrass R.E. Arthropod Anatomy 1965, Hafner Publishing Company, New York, 193-224.
111. Stankiewicz M., Hamon A., Benkhalifa R., Kadziela W., Hue B., Lucas S., Mebs D., Pelhate M. Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophila muscarinic receptor. Toxicon 1999, 37:1431-1445.
112. Stone C.A., Wenger H.C., Ludden C.T., Stavorski J.M., Ross C.A. Antiserotonin-antihistaminic properties of cyproheptadine. J. Pharmacol. Exp. Ther. 1961, 131:73.
113. Sulkowski E., Björk W., Laskowski M. A specific and nonspecific alkaline monophosphatase in the venom of Bothrops atrox and their occurrence in the purified venom phosphodiesterase. J. Biol. Chem. 1963, 238:2477-2486.
114. Supakthanasiri P., Ruxrungtham K., Klaewsongkram J., Chantaphakul H. Anaphylaxis to centipede bite. J. Allergy Clinical Immunology 2004, 113:S244.
115. Sutherland S.K., Tibballs J. Australian Animal Toxins: the Creatures, Their Toxins and Care of the Poisoned Patient 2001, Oxford University Press, Melbourne. second ed.
116. Trevisan-Silva D., Gremski L.H., Chaim O.M., da Silveira R.B., Meissner G.O., Mangili O.C., Barbaro K.C., Gremski W., Veiga S.S., Senff-Ribeiro A. Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles). Biochimie 2010, 92:21-32.
117. Tu A.T., Chua A. Acid and alkaline phosphomonoesterase activities in snake venoms. Comp. Biochem. Physiol. 1966, 17:297-307.
118. Undheim E.A.B., Georgieva D.N., Thoen H.H., Norman J.A., Mork J., Betzel C., Fry B.G. Venom on ice: first insights into Antarctic octopus venoms. Toxicon 2010, 56:897-913.
119. Usmanov P.B., Nuritova F.A. The anticoagulant action of phospholipase A from Eresus niger spider venom. Toxicon 1994, 32:625-628.
120. Uzel A.P., Steinmann G., Bertino R., Korsaga A. Dermohypodermite bactérienne et phlegmon du membre supérieur par morsure de scolopendre: à propos de deux cas. Chir. Main 2009, 28:322-325.
121. Vassilevski A., Kozlov S., Grishin E. Molecular diversity of spider venom. Biochem. Mosc 2009, 74:1505-1534.
122. Vazirianzadeh B., Rahmanei A.H., Moravvej S.A. Two cases of chilopoda (centipede) biting in human from Ahwaz, Iran. Pak. J. Med. Sci. Q. 2007, 23:956.
123. Veraldi S., Chiaratti A., Sica L. Centipede bite: a case report. Arch. Dermatol. 2010, 146:807-808.
124. Welsh J.H., Batty C.S. 5-Hydroxytryptamine content of some arthropod venoms and venom-containing parts. Toxicon 1963, 1:165-170.
125. Wenhua R., Shuangquan Z., Daxiang S., Kaiya Z., Guang Y. Induction, purification and characterization of an antibacterial peptide scolopendrin I from the venom of centipede Scolopendra subspinipes mutilans. Indian J. Biochem. Biophys 2006, 43:88-93.
126. Winquist R.J., Siegl P.K., Baskin E.P., Bohn D.L., Morgan G., Wallace A.A. Calcium entry blocker activity of cyproheptadine in isolated cardiovascular preparations. J. Pharmacol. Exp. Ther. 1984, 230:103.
127. Xin Y., Choo Y.M., Hu Z., Lee K.S., Yoon H.J., Cui Z., Sohn H.D., Jin B.R. Molecular cloning and characterization of a venom phospholipase A2 from the bumblebee Bombus ignitus. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2009, 154:195-202.
128. Yildiz A., Biçeroglu S., Yakut N., Bilir C., Akdemir R., Akilli A. Acute myocardial infarction in a young man caused by centipede sting. Emerg. Med. J. 2006, 23:e30.
129. Zychar B.C., Dale C.S., Demarchi D.S., Gonçalves L.R.C. Contribution of metalloproteases, serine proteases and phospholipases A2 to the inflammatory reaction induced by Bothrops jararaca crude venom in mice. Toxicon 2010, 55:227-234.