Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions

Leukemia Research

Volumn 35, Issue 4, 2011, Pages 545-550

  Yung, Eric ^a   Sekulovic, Sanja ^a   Argiropoulos, Bob ^a   Lai, Courteney K ^a   Leung, Malina ^a   Berg, Tobias ^a   Vollett, Sarah ^a   Chang, Vicky Chi Dan ^a   Wan, Adrian ^a   Wong, Sandy ^a   Humphries, R Keith ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Fusion protein; Hematopoiesis; Leukemia; Nucleoporin; NUP98; Stem cell; Transcription regulation

Indexed keywords

HISTONE ACETYLTRANSFERASE PCAF; HYBRID PROTEIN; NUCLEOPORIN 98; NUCLEOPORIN 98 HOX PROTEIN FUSION PROTEIN; ONCOPROTEIN; PROTEIN MEIS1; PROTEIN RAE1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL REGENERATION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION;

ACUTE DISEASE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BONE MARROW CELLS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; FEMALE; HOMEODOMAIN PROTEINS; KAPLAN-MEIER ESTIMATE; LEUKEMIA, MYELOID; LUMINESCENT PROTEINS; MALE; MICE; MICE, INBRED C57BL; MUTATION; NEOPLASM PROTEINS; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PORE COMPLEX PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; ONCOGENE PROTEINS, FUSION; P300-CBP TRANSCRIPTION FACTORS; PROTEIN BINDING; REPETITIVE SEQUENCES, AMINO ACID;

EID: 79952363190     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.10.006     Document Type: Article

References (24)

1. Nakamura T., Largaespada D.A., Lee M.P., Johnson L.A., Ohyashiki K., Toyama K., Chen S.J., Willman C.L., Chen I.M., Feinberg A.P., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nature Genetics 1996, 12:154-158.
2. Borrow J., Shearman A.M., Stanton V.P., Becher R., Collins T., Williams A.J., Dubé I., Katz F., Kwong Y.L., Morris C., Ohyashiki K., Toyama K., Rowley J., Housman D.E. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nature Genetics 1996, 12:159-167.
3. Slape C., Lin Y., Hartung H., Zhang Z., Wolff L., Aplan P. NUP98-HOX translocations lead to myelodysplastic syndrome in mice and men. JNCI Monographs 2008, 2008:p64.
4. Hirose K., Abramovich C., Argiropoulos B. Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor. Oncogene 2008, 6056-6067.
5. Yassin E.R., Sarma N.J., Abdul-nabi A.M., Dombrowski J., Han Y., Takeda A., Yaseen N.R. Dissection of the transformation of primary human hematopoietic cells by the oncogene NUP98-HOXA9. PLoS One 2009, 4.
6. Moore M.A., Chung K.Y., Plasilova M., Schuringa J.J., Shieh J., Zhou P., Morrone G. NUP98 dysregulation in myeloid leukemogenesis. Annals of the New York Academy of Sciences 2007, 1106:114-142.
7. Wang X., Babu J.R., Harden J.M., Jablonski S.A., Gazi M.H., Lingle W.L., de Groen P.C., Yen T.J., van Deursen J.M. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. The Journal of Biological Chemistry 2001, 276:26559-26567.
8. Blevins M.B., Smith A.M., Phillips E.M., Powers M.A. Complex formation among the RNA export proteins Nup98, Rae1/Gle2, and TAP. The Journal of Biological Chemistry 2003, 278:20979-20988.
9. Baker D.J., Dawlaty M.M., Galardy P., van Deursen J.M. Mitotic regulation of the anaphase-promoting complex. Cellular and Molecular Life Sciences: CMLS 2007, 64:589-600.
10. Kasper L.H., Brindle P.K., Schnabel C.A., Pritchard C.E., Cleary M.L., Deursen J.M. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98- HOXA9 oncogenicity. Molecular and cellular biology 1999, 19:764-776.
11. Bai X., Gu B., Yin T., Niu C., Xi X., Zhang J., Chen Z., Chen S. Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats. Cancer Research 2006, 66:4584-4590.
12. D. Jankovic, P. Gorello, T. Liu, S. Ehret, R. La Starza, C. Desjobert, F. Baty, M. Brutsche, P. Jayaraman, A. Santoro, others, Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia, Blood 2008;111:5672.
13. Wang G., Cai L., Pasillas M., Kamps M. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nature Cell Biology 2007, 9:804-812.
14. Ohta H., Sekulovic S., Bakovic S., Eaves C.J., Pineault N., Gasparetto M., Smith C., Sauvageau G., Humphries R.K. Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions. Experimental Hematology 2007, 35:817-830.
15. Choi Y., Elagib K.E., Delehanty L.L., Goldfarb A.N. Erythroid inhibition by the leukemic fusion AML1-ETO is associated with impaired acetylation of the major erythroid transcription factor GATA-1. Cancer Research 2006, 66:2990-2996.
16. Argiropoulos B., Palmqvist L., Yung E., Kuchenbauer F., Heuser M., Sly L.M., Wan A., Krystal G., Humphries R.K. Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. Experimental Hematology 2008, 36:845-859.
17. Pawliuk R., Kay R., Lansdorp P., Humphries R.K. Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer. Blood 1994, 84:2868-2877.
18. Pineault N., Buske C., Feuring-buske M., Abramovich C., Rosten P., Hogge D.E., Aplan P.D., Humphries R.K. Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1. Blood 2003, 101:4529-4538.
19. Pineault N., Abramovich C., Ohta H., Humphries R.K. Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1. Molecular and Cellular Biology 2004, 24:1907-1917.
20. Capelson M., Liang Y., Schulte R., Mair W., Wagner U., Hetzer M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell 2010, 140:372-383.
21. Kalverda B., Pickersgill H., Shloma V.V., Fornerod M. Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. Cell 2010, 140:360-371.
22. Hou C., Corces V.G. Nups take leave of the nuclear envelope to regulate transcription. Cell 2010, 140:306-308.
23. Kasper L.H., Boussouar F., Ney P.A., Jackson C.W., Rehg J., van Deursen J.M., Brindle P.K. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 2002, 419:738-743.
24. Oike Y., Takakura N., Hata A., Kaname T., Akizuki M., Yamaguchi Y., Yasue H., Araki K., Yamamura K., Suda T. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. Blood 1999, 93:2771-2779.