Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats

Cancer Research

Volumn 66, Issue 9, 2006, Pages 4584-4590

  Bai, Xue Tao ^a   Gu, Bai Wei ^a   Yin, Tong ^a   Niu, Chao ^a   Xi, Xiao Dong ^a   Zhang, Ji ^a   Chen, Zhu ^a   Chen, Sai Juan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HISTONE DEACETYLASE 1; HYBRID PROTEIN; NUCLEOPORIN 98;

ACUTE LEUKEMIA; ADULT; ANAMNESIS; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; GENE REPRESSION; HUMAN; LEUKEMOGENESIS; MALE; MOLECULAR CLONING; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN DOMAIN;

BINDING SITES; BLAST CRISIS; CELL NUCLEUS; CLONING, MOLECULAR; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, FOS; HISTONE DEACETYLASES; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; NUCLEAR PORE COMPLEX PROTEINS; ONCOGENE PROTEINS, FUSION; PROTEIN STRUCTURE, TERTIARY; TRANS-ACTIVATION (GENETICS);

EID: 33646417021     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3101     Document Type: Article

References (33)

1. Rabbitts TH. Chromosomal translocations in human cancer. Nature 1994;372:143-9.
2. Lallemand-Breitenbach V, Zhu J, Kogan S, Chen Z, de The H. Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia. Nat Rev Cancer 2005;5:821-7.
3. Slape C, Aplan PD. The role of NUP98 gene fusions in hematologic malignancy. Leuk Lymphoma 2004;45:1341-50.
4. Nebral K, Schmidt HH, Haas OA, Strehl S. NUP98 is fused to topoisomerase (DNA) IIβ 180 kDa (TOP2B) in a patient with acute myeloid leukemia with a new t(3;11)(p24;p15). Clin Cancer Res 2005;11:6489-94.
5. Tosi S, Ballabio E, Teigler-Schlegel A, et al. Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-6orf80 fusion in a case of acute megakaryoblastic leukemia. Genes Chromosomes Cancer 2005;44:225-32.
6. van Zutven LJ, Onen E, Velthuizen SC, et al. Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer 2006;45:437-46.
7. von Lindern M, Fornerod M, van Baal S, et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric leukemia-specific dek-can mRNA. Mol Cell Biol 1992;12:1687-97.
8. von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G. Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene. Mol Cell Biol 1992;12:3346-55.
9. Wang Y, Gu MM, Tan Y, et al. Development of human myeloid leukemia-like phenotype in NUP98-PMX1 transgenic mice. Zhonghua Xue Ye Xue Za Zhi 2004;25:262-5.
10. Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol 1999;19:764-76.
11. Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G. NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J 2001;20:350-61.
12. Gurevich RM, Aplan PD, Humphries RK. NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Blood 2004;104:1127-36.
13. Lin YW, Slape C, Zhang Z, Aplan PD. NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood 2005;106:287-95.
14. Pineault N, Buske C, Feuring-Buske M, et al. Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis. Blood 2003;101:4529-38.
15. Dash AB, Williams IR, Kutok JL, et al. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A 2002;99:7622-7.
16. Ghannam G, Takeda A, Camarata T, Moore MA, Viale A, Yaseen NR. The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells. J Biol Chem 2004;279:866-75.
17. Nakamura T, Yamazaki Y, Hatano Y, Miura I. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). Blood 1999;94:741-7.
18. Gu BW, Wang Q, Wang JM, et al. Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity. Leukemia 2003;17:1858-64.
19. Bei L, Lu Y, Eklund EA. HoxA9 activates transcription of the gene encoding gp91PHOX during myeloid differentiation. J Biol Chem 2005;280:12359-70.
20. Liu H, Chen B, Xiong H, et al. Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. Oncogene 2004;23:3385-94.
21. Yamauchi K, Holt K, Pessin JE. Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. J Biol Chem 1993;268:14597-600.
22. Janknecht R, Nordheim A. Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene 1996;12:1961-9.
23. Grueneberg DA, Natesan S, Alexandre C, Gilman MZ. Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science 1992;257:1089-95.
24. Martin KA, Gualberto A, Kolman MF, Lowry J, Walsh K. A competitive mechanism of CArG element regulation by YY1 and SRF: implications for assessment of Phox1/MHox transcription factor interactions at CArG elements. DNA Cell Biol 1997;16:653-61.
25. Yang SH, Vickers E, Brehm A, Kouzarides T, Sharrocks AD. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1. Mol Cell Biol 2001;21:2802-14.
26. de Belle I, Walker PR, Smith IC, Sikorska M. Identification of a multiprotein complex interacting with the c-fos serum response element. Mol Cell Biol 1991;11:2752-9.
27. Goodman RH, Smolik S. CBP/p300 in cell growth, transformation, and development. Genes Dev 2000;14:1553-77.
28. Liebermann DA, Gregory B, Hoffman B. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol 1998;12:685-700.
29. Liebermann DA, Hoffman B. Myeloid differentiation (MyD) primary response genes in hematopoiesis. Oncogene 2002;21:3391-402.
30. Bjerregaard MD, Jurlander J, Klausen P, Borregaard N, Cowland JB. The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow. Blood 2003;101:4322-32.
31. Lord KA, Abdollahi A, Hoffman-Liebermann B, Liebermann DA. Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation. Mol Cell Biol 1993;13:841-51.
32. Mitchell RL, Zokas L, Schreiber RD, Verma IM. Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation. Cell 1985;40:209-17.
33. Radu A, Moore MS, Blobel G. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell 1995;81:215-22.