Aberrant methylation of tumor suppressor genes in patients with refractory anemia with ring sideroblasts

Leukemia Research

Volumn 35, Issue 4, 2011, Pages 479-483

  Valencia, Ana ^a   Cervera, José ^a   Such, Esperanza ^a   Ibañez, Mariam ^a   Gómez, Inés ^a   Luna, Irene ^a   Senent, Leonor ^a   Oltra, Silvestre ^a   Sanz, Miguel A ^a   Sanz, Guillermo F ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

CDKN2B; Methylation; MLPA; MSP; Refractory anemia with ring sideroblasts

Indexed keywords

ARTICLE; CDH13 GENE; CDKN2B GENE; CELL CYCLE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; FHIT GENE; GENE; GENE AMPLIFICATION; GENETIC ANALYSIS; HUMAN; MALE; NEUTROPHIL COUNT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; RARB GENE; RASSF1 GENE; REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS; THROMBOCYTE COUNT; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, REFRACTORY; ANEMIA, SIDEROBLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DNA METHYLATION; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS; RECEPTORS, RETINOIC ACID; TUMOR SUPPRESSOR PROTEINS;

EID: 79952363017     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.08.012     Document Type: Article

References (25)

1. Brunning R.D., Bennett J.M., Flandrin G., Matutes E., Heed D., Vardiman J.W., et al. Refractory anaemia with ring sideroblasts. Tumours of haematopoietic and lymphoid tissues 2001, 69. World Health Organization, IARC Press, Lyon, France. E.S. Jaffe, N.L. Harris, H. Stein, J.W. Vardiman (Eds.).
2. Germing U., Gattermann N., Strupp C., Aivado M., Aul C. Validation of the WHO proposals for a new classification of the myelodysplastic syndromes: a retrospective analysis of 1600 patients. Leuk Res 2000, 24:983-992.
3. Hasserjian R.P., Gattermann N., Bennett J.M., Brunning R.D., Thiede J. Refractory anaemia with ring sideroblasts. WHO classification of tumours of haematopoietic and lymphoid tissues 2008, 76-81. World Health Organization, IARC Press, Lyon, France. S. Swerdlow, E. Campos, N. Lee Harris, E. Jaffe, S. Pileri, H. Stein, J. Thiele, J. Vardiman (Eds.).
4. Greenberg P., Cox C., LeBeau M.M., Fenaux P., Morel P., Sanz G., et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997, 89:2079-2088.
5. Cazzola M., Barosi G., Gobbi P.G., Invernizzi R., Riccardi A., Ascari E. Natural history of idiopathic refractory sideroblastic anemia. Blood 1988, 71:305-312.
6. List A., Kurtin S., Roe D.J., Buresh A., Mahadevan D., Fuchs D., et al. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med 2005, 352:549-557.
7. Lyons R.M., Cosgriff T.M., Modi S.S., Gersh R.H., Hainsworth J.D., Cohn A.L., et al. Hematologic response to three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromes. J Clin Oncol 2009, 27:1850-1856.
8. Boultwood J., Pellagatti A., Nikpour M., Pushkaran B., Fidler C., Cattan H., et al. The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts. PLoS One 2008, 3:e1970.
9. Qian J., Yao D.M., Lin J., Wang Y.L., Han L.X., Xu W.R., et al. Methylation of DAPK1 promoter: frequent but not an adverse prognostic factor in myelodysplastic syndrome. Int J Lab Hematol 2009, 82:119-123.
10. Lin J., Yao D.M., Qian J., Wang Y.L., Han L.X., Jiang Y.W., et al. Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome. Leuk Res 2008, 32:1541-1545.
11. Johan M.F., Bowen D.T., Frew M.E., Goodeve A.C., Reilly J.T. Aberrant methylation of the negative regulators RASSFIA, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol 2005, 129:60-65.
12. Jiang Y., Dunbar A., Gondek L.P., Mohan S., Rataul M., O'Keefe C., et al. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 2009, 113:1315-1325.
13. Uchida T., Kinoshita T., Nagai H., Nakahara Y., Saito H., Hotta T., et al. Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood 1997, 90:1403-1409.
14. Quesnel B., Guillerm G., Vereecque R., Wattel E., Preudhomme C., Bauters F., et al. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood 1998, 91:2985-2990.
15. Tien H.F., Tang J.H., Tsay W., Liu M.C., Lee F.Y., Wang C.H., et al. Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation. Br J Haematol 2001, 112:148-154.
16. Chen W., Wu S. Hypermethylation of the p15INK4B gene in acute leukemia and myelodysplastic syndromes. Chin Med J 2002, 115:987-990.
17. Aggerholm A., Holm M.S., Guldberg P., Olesen L.H., Hokland P. Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 2006, 76:23-32.
18. Shen L., Kantarjian H., Guo Y., Lin E., Shan J., Huang X., et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 2010, 28:605-613.
19. Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A., Gralnick H.R., et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982, 51:189-199.
20. Nygren A.O., Ameziane N., Duarte H.M., Vijzelaar R.N., Waisfisz Q., Hess C.J., et al. Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res 2005, 33:e128.
21. Herman J.G., Graff J.R., Myohanen S., Nelkin B.D., Baylin S.B., Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996, 93:9821-9826.
22. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966, 50:163-170.
23. Melki J.R., Vincent P.C., Clark S.J. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res 1999, 59:3730-3740.
24. Galm O., Wilop S., Lüders C., Jost E., Gehbauer G., Herman J.G., et al. Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia. Ann Hematol 2005, 84(Suppl. 1):39-46.
25. Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002, 21:5427-5440.