Hypermethylation of the p15INK4B gene in acute leukemia and myelodysplastic syndromes

Chinese Medical Journal

Volumn 115, Issue 7, 2002, Pages 987-990

  Chen, Hua ^a   Wu, Shulan ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Acute leukemia; DNA methylation; Myelodysplastic syndromes; p15INK4B; Suppressor gene

Indexed keywords

PROTEIN P15;

ACUTE LEUKEMIA; ARTICLE; CANCER RECURRENCE; CANCER REGRESSION; CONTROLLED STUDY; CPG ISLAND; GENE FREQUENCY; HIGH RISK PATIENT; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; MARKER GENE; MINIMAL RESIDUAL DISEASE; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROTEIN METHYLATION; RISK ASSESSMENT;

CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOCYTIC, ACUTE; MYELODYSPLASTIC SYNDROMES; TUMOR SUPPRESSOR PROTEINS;

EID: 0036316318     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. A cell cycle regulator potentially involved in many tumor types
2. Selective variegated methylation of the p15 CpG island in acute myeloid leukemia
3. INK4A characterize the major types of hematological malignancies
4. INK4B methylation in acute myeloid leukemia
5. INK4B gene in myelodysplastic syndrome is frequent and acquired during disease progression
6. INK4B gene in myelodysplastic syndromes
7. Methylation-specific PCR: A novel assay for methylation status of CpG islands
8. Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: Potential prognostic implications
9. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex