HNK2 receptor antagonists. the use of intramolecular hydrogen bonding to increase solubility and membrane permeability

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1807-1809

  Ettorre, Alessandro ^a   D'Andrea, Piero ^a   Mauro, Sandro ^a   Porcelloni, Marina ^a   Rossi, Cristina ^a   Altamura, Maria ^a   Catalioto, Rose M ^a   Giuliani, Sandro ^a   Maggi, Carlo Alberto ^a   Fattori, Daniela ^a  

^a Menarini Ricerche SpA   (Italy)

Author keywords

Hydrogen bond; NKA antagonists; Permeability

Indexed keywords

AROMATIC AMINE; BENZAMIDE DERIVATIVE; FUNCTIONAL GROUP; HYDROGEN; NEUROKININ 2 RECEPTOR ANTAGONIST; PEPTIDE DERIVATIVE; PYRIDINE DERIVATIVE; NEUROKININ 2 RECEPTOR; OLIGOPEPTIDE;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE PERMEABILITY; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HYDROGEN BOND; LIPOPHILICITY; MEMBRANE TRANSPORT; PHYSICAL CHEMISTRY; STRUCTURE ANALYSIS; DRUG ANTAGONISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLUBILITY;

CELL MEMBRANE PERMEABILITY; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; OLIGOPEPTIDES; RECEPTORS, NEUROKININ-2; SOLUBILITY;

EID: 79952361347     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.074     Document Type: Article

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