Synthesis and biological evaluation of some [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines

Letters in Drug Design and Discovery

Volumn 8, Issue 2, 2011, Pages 189-200

  Naveenaa, Channamata Shankara ^b   Poojary, Boja ^a   Chandrashekhar, Chikkanna ^c   Kumari, Nalilu Suchetha ^d  

^a MANGALORE UNIVERSITY   (India)

^b SeQuent Scientific Limited   (India)

^c SDM College   (India)

^d NITTE DEEMED TO BE UNIVERSITY   (India)

Author keywords

2 (Aryloxymethyl)phenyl moiety; Anti inflammatory activity; Antimicrobial activity; N Bridged condensed heterocycle; Triazolothiadiazines; Triazolothiadiazoles

Indexed keywords

[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOLE; CIPROFLOXACIN; FLUCONAZOLE; THIADIAZINE DERIVATIVE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED RADIATION; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 79952353089     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018011794183806     Document Type: Article

References (24)

1. Demirbas, N.; Demirbas, A.; Karaoglu, S.A.; Çelik, E. Synthesis and antimicrobial activities of some new [1,2,4]triazolo [3,4- b] [1,3,4]thiadiazoles and [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines. ARKIVOC, 2005, (i), 75-91. (Pubitemid 40390032)
2. Holla, B.S.; Prasanna, C.S.; Boja Poojary; Ashok, M.; Rao, K.S.; Shridhara, K. Characterization and antibacterial studies of some 1,2,4-triazole derivatives containing a 6-chloropyridin-3-yl methyl moiety. Z. Naturforsch., 2006, 61b, 334-338. (Pubitemid 43709827)
3. Kokil, G.R.; Rewatkar, P.V.; Gosain, S.; Saurabh, A.; Verma, A.; Kalra, A.; Thareja, S. Synthesis and in vitro evaluation of novel 1, 2, 4-triazole derivatives as antifungal agents. Lett. Drug Des. Discov., 2010, 7(1), 46-49.
4. Mihaela, M.; Valeriu, S.; Lenuta, P.; Marcel, P.; Jacques, D.;Cristian, P. Synthesis and biological activity of some new 1,3,4- thiadiazole and 1,2,4-triazole compounds containing a phenylalanine moiety. Molecules, 2009, 14, 2621-2631.
5. Hemdan, M. M.; Fahmy, A.F.; El-Sayed, A.A. Synthesis and antimicrobial study of 1,2,4-triazole, quinazoline and benzothiazole derivatives from 1-naphthoylisothiocyanate. J. Chem. Res., 2010, 2010(4), 219-221.
6. Al Bay, H.; Quaddouri, B.; Guaadaoui, A.; Touzani, R.; Benchat, N.E.; Hamal, A.; Taleb, M.; Bellaoui, M.; El Kadiri, S. Synthesis and biological activity of new triazole compounds. Lett. Drug Des. Discov., 2010, 7(1), 41-45.
7. Zhang, Y.; Zhou, J.; Pan, W.; Wu, X.; Wang, S. Synthesis and biological study of 3-butyl-1-(2,6-dichloro phenyl)- 1H-[1,2,4]triazol-5(4H)-one derivatives as anti-hypertension drugs. Lett. Drug Des. Discov., 2010, 7(1), 18-22.
8. Turan-Zitouni, G.; Kaplancikli, Z.A.; Ozdemir, A.; Chevallet, P.; Kandilci, H.B.; Gumusel, B. Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents. Archv. Pharm., 2007, 340(11), 586-590. (Pubitemid 350178675)
9. EI Shehry, M.F.; Abu-Hashem, A.A.; EI-Telbani, E.M. Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines ) as anti-inflammatory and molluscicidal agents. Eur. J. Med.Chem., 2010, 45, 1906-1911.
10. Holla, B. S.; Veerendra, B.; Shivananda, M.K.; Boja Poojary. Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles. Eur. J. Med. Chem., 2003, 38, 759-767. (Pubitemid 36976785)
11. Holla, B.S.; Poorjary, N.K.; Rao, S.B.; Shivananda, M.K. New bisamino mercapto triazoles and bis-triazolothiadiazoles as possible anticancer agents. Eur. J. Med. Chem., 2002, 37, 511-517. (Pubitemid 35245174)
12. Hakan, B.; Nesrin, K.; Deniz, S.; Ahmet, D.; Sengul, A.K.; Neslihan, D. Synthesis and antimicrobial activities of some new 1,2,4- triazole derivatives. Molecules, 2010, 15, 2427-2438.
13. El-Sayed, W.A.; Omar, M.A.; Marwa, M.H.; Abdel-Rahman, A.A.- H. Synthesis and anti microbial activity of new substituted fused 1,2,4-triazole derivatives. Z. Naturforsch., 2010, 65, 22-28.
14. Mathew, V.; Keshavayya, J.; Vidya, V.P. Heterocyclic system containing bridgehead nitrogen atom: Synthesis and pharmacological activities of some substituted 1,2,4-triazolo [3,4-b]-1,3,4- thiadiazoles. Eur. J. Med. Chem., 2006, 41, 1048-1058. (Pubitemid 44353864)
15. Tozkoparam, B.; Aytac, S.P.; Aktay, G. Novel 3,6-disubstituted 7H-1,2,4-triazolo [3,4-b] [1,3,4] thiadiazines: Synthesis, characterization and evaluation of analgesic /anti-inflammatory, antioxidant activities. Arch. Pharm. ( Weinheim), 2009, 342(5), 291-298.
16. Husain, A,; Naseer, M.A.; Sarafroz, M. Synthesis and anticonvulsant activity of some novel fused heterocyclic 1,2,4-triazolo [3,4-b] [1,3,4] thiadiazole derivatives. Acta Pol. Pharm., 2009, 66(2), 135-140.
17. Mithun, A.; Holla, B.S. Convenient Synthesis Of Some Triazolothiadiazoles and triazolothiadiazines carrying 4-methylthiobenzyl moiety as possible antimicrobial agents. J. Pharmacol. Toxicol., 2007, 2(3), 256-263.
18. Salgin-Goksen, U.; Gokhan, K.; Goktas, O.; Koysal, Y.; Kilic, E.; Isic, S.; Aktay, G.; Ozalp, M. 1-Acythiosemi carbazides,1,2,4- triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic, antiinflammatory and antimicrobial activities. Bioorg. Med. Chem., 2007, 15(17), 5738-5751.
19. Holla, B.S.; Sarojini, B.K.; Rao, S.B.; Akberali, P.M.; Kumari, N.S.; Shetty, V. Synthesis of some halogen-containing 1,2,4- triazolo-1,3,4- thiadiazines and their antibacterial and anticancer screening studies - Part I. Il Farmaco, 2001, 56, 565-570. (Pubitemid 32727927)
20. Prakash, K .; Jagdeesh Prasad, D.; Mithun, A.; Mahalinga, K.; Poojary, B.; Holla, B.S. Synthesis, antimicrobial and antiinflammatory activities of some1,2,4-triazolo [3,4- b] [1,3,4]thiadiazoles and 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazines bearing trichlorophenyl moiety. Eur. J. Med. Chem., 2008, 43, 808-815. (Pubitemid 351454053)
21. Bauer, A.N.; Kirby, W.N.M.; Sherries, J.C.; Truck, M. Antibiotic susceptibility testing by a standardized single disk method. Am. J. Clin. Pathol., 1996, 45, 493-496.
22. Winter, C.A.; Risley, E.A.; Nuss, G.W. Carrageenin-induced oedema in hind paw of the rat as an assay for antiiflammatory drugs. Proc. Soc. Exp. Biol. Med., 1962, 111, 544-547.
23. Limban, C.; Chifiriuc, M.C.B.; Missir, A.V.; Chiritǎ, I.C.; Bleotu, C. Antimicrobial activity of some new thioureides derived from 2- (4-chlorophenoxymethyl)benzoic acid. Molecules, 2008, 13, 567-580.
24. Vogel, A.I. Text book of Practical Organic Chemistry, 5th ed.; Wiley: New York, 1989, p.1077.