Synthesis and in vitro evaluation of novel 1, 2, 4-triazole derivatives as antifungal agents

Letters in Drug Design and Discovery

Volumn 7, Issue 1, 2010, Pages 46-49

  Kokil, Ganesh R ^a,c   Rewatkar, Prarthana V ^b   Gosain, Sandeep ^b   Aggarwal, Saurabh ^c   Verma, Arunima ^c   Kalra, Atin ^c   Thareja, Suresh ^c  

^a Sinhgad Institute of Pharmaceutical Sciences   (India)

^b STES's Smt Kashibai Navale College of Pharmacy   (India)

^c GVM College of Pharmacy   (India)

Author keywords

Antifungal; Azole; Coumarin; Minimum inhibitory concentration; Triazole

Indexed keywords

ERGOSTEROL; FLUCONAZOLE; HYMECROMONE; ITRACONAZOLE; KETOCONAZOLE; LANOSTEROL; TRIAZOLE DERIVATIVE; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; DRUG SYNTHESIS; FUNGICIDAL ACTIVITY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MORBIDITY; MORTALITY; MYCOSIS; NONHUMAN; PRIORITY JOURNAL;

EID: 77949698025     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018010789869415     Document Type: Article

References (19)

1. Finkelstein, E.; Amichai, B.; Grunwald, M. H. Griseofulvin and its uses. Int. J. Antimicrob. Agents, 1996, 6, 189-194.
2. Rando, R. R. Polyenes and vision. Chem. Biol., 1996, 3, 255-262.
3. Nailor, M. D.; Sobel, J. D. Erratum: Progress in antifungal therapy: Echinocandins versus azoles. Drug Discov. Today: Ther. Strateg., 2006, 3, 221-226.
4. Kauffman, C. A.; Carver, P. L. Use of azoles for systemic antifungal therapy. Adv. Pharmacol., 1997, 39, 143-189.
5. Birnbaum, J. E.; Pharmacology of the allylamines. J. Am. Acad. Dermatol., 1990, 23, 782-785.
6. Wise, G. J.; Wainstein, S.; Goldberg, P.; Kozinn, P. J. Flucytosine in urinary Candida infections. Urology, 1974, 3, 708-711.
7. Odds, F. C. Antifungal agents: their diversity and increasing sophistication. Mycologist, 2003, 17, 51-53.
8. Guardiola, H. M.; Foster, L.; Mushrush, D; Vaz, A. D. Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis. Biochem. Pharmacol, 2001, 61, 1463-1470.
9. Yoshida, Y.; Aoyama, Y. In Vitro and In Vivo Evaluation of Antifungal Agents; Iwata, K.; Vanden Bossche, H. Eds.; Elsevier Science, Amsterdam, 1986; pp. 123-134.
10. Aoyama, Y.; Yoshida, Y. The 3-hydroxy group of lanosterol is essential for orienting the substrate site of cytochrome P-450 (14DM) (lanosterol 14 alpha- demethylase). Biochim. Biophys. Acta, 1989, 1006, 209-213.
11. Willins, D. A.; Kessler, M.; Walker, S. S.; Reyes, G. R; Cottarel, G. Genomics strategies for antifungal drug discovery from gene discovery to compound screening. Curr. Pharm. Des, 2002, 8, 1137-1154.
12. Richardson, M. D. Changing patterns and trends in systemic fungal infection. J. Antimicrob. Chemother. 2005, 56, i5-i11
13. Kostova, I. Synthetic and natural coumarins as cytotoxic agents. Curr. Med. Chem. Anti-Cancer Agents, 2005, 5, 29-46.
14. Mouri, T.; Yano, T.; Kochi, S.; Ando, T.; Hori, M. Synthesis and antifungal activity of new 3, 4, 7-trisubstituted coumarins. J. Pestic. Sci. 2005, 30, 209-213.
15. Satyanarayana, V. S. V.; Sreevani, P.; Sivakumar, A.; Vijayakumar, V. Synthesis and antimicrobial activity of new Schiff bases containing coumarin moiety and their spectral characterization. ARKIVOC, 2008, 17, 221-233.
16. Ramesh, P.; Das, A. T.; Mohandass, P.; Nagasathya, R. The structure of Hantzsch Coumarin. Indian J. Chem., 2008, 47B, 1447-1450.
17. Pandey, V. K.; Singh, V. K.; Tandon, M.; Joshi, M. N.; Bajpai, S. K.; Synthesis and antiviral activity of furobenzopyrones. Indian J. Chem., 2004, 43B, 1770- 1174.
18. Massa, S.; Di Santo, R.; Artico, M.; Costi, R.; Apuzzo, G.; Simonetti, G.; Artico, M. Novel invitro highly active antifungal agents with pyrroles and imidazole moieties. Med. Chem. Res., 1992, 2 , 148-153.
19. Massa, S.; Stefancich, G.; Corelli, F.; Silvestri, R.; Mai, A.; Artico, M.; Panico, S.; Simonetti, N. Research on antibacterical and antifungal agents. Arch. Pharm. (Weinheim), 1989, 322, 369-373.