Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications

BMC Immunology

Volumn 12, Issue , 2011, Pages

  Khan, Mohd W A ^a,b   Banga, Kamalpreet ^a   Mashal, Subhash N ^a   Khan, Wahid A ^b,c  

^a Faculty of Medicine and Health Sciences Gomail   (Libyan Arab Jamahiriya)

^b ALIGARH MUSLIM UNIVERSITY   (India)

^c KING KHALID UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; IMMUNOGLOBULIN G; REACTIVE OXYGEN METABOLITE; AUTOANTIBODY; EPITOPE; GLUTAMATE DECARBOXYLASE;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; QUANTITATIVE ANALYSIS; ANTIBODY SPECIFICITY; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; PILOT STUDY;

ANTIBODY SPECIFICITY; AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; GLUTAMATE DECARBOXYLASE; HUMANS; PILOT PROJECTS; REACTIVE OXYGEN SPECIES;

EID: 79952349460     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-12-19     Document Type: Article

References (26)

1. Banga JP, Moore JK, Duhindan N, Madec AM, Vanendert PM, Orgiazzi J, Endl J. Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient. Clin Exp Immunol 2004, 135:74-84. 10.1111/j.1365-2249.2004.02343.x, 1808922, 14678267.
2. Falorni A, Kassi G, Murdolo G, Calcinaro F. Controversies on humoral immune markers of insulin-dependent diabetes mellitus. J Ped Endocrinol Metab 1998, 11:307-317.
3. Bonifacio E, Genovese S, Braghi S. Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetol 1995, 38:816-822.
4. Jakus V, Rietbrock N. Advance glycation end-products and the progress of diabetic vascular complications. Physiol Res 2004, 53:131-142.
5. Chaturvedi N, Bendinelli S, Mangili R, Penno G, Rottiers RE, Fuller JH. Microalbuminuria in type 1 diabetes: rate, risk factors and glycemic threshold. Kidney Int 2001, 60:219-227. 10.1046/j.1523-1755.2001.00789.x, 11422754.
6. Khan MWA, Sherwani S, Khan WA, Moinuddin, Ali R. Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes. Autoimmunity 2009, 42:150-158. 10.1080/08916930802468276, 19085183.
7. Hampe CS, Hammerle LP, Bekris L, Ortqvist E, Kockum I, Rolandsson O, Landin-Olsson M, Torn C, Persson B, Lernmark A. Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes. J Clin Endocrinol Metab 2000, 85:4671-4679. 10.1210/jc.85.12.4671, 11134126.
8. Bjork E, Velloso LA, Kampe O, Karlsson FA. GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes 1994, 43:161-165. 10.2337/diabetes.43.1.161, 7505244.
9. Hampe CS, Ortqvist E, Persson B, Schranz DB, Lernmark A. Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes. Horm Metab Res 1999, 31:553-557. 10.1055/s-2007-978794, 10596964.
10. Scofield RH, Kaufman KM, Baber U, James JA, Harley JB, Kurien BT. Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse. Arthritis Rheum 1999, 42:1017-24. 10.1002/1529-0131(199905)42:5<1017::AID-ANR22>3.0.CO;2-7, 10323459.
11. Coughlan MT, Thorburn DR, Penfold SA, Laskowski A, Harcourt BE, Sourris KC, Tan AL, Fukami K, Thallas-Bonke V, Nawroth PP, Brownlee M, Bierhaus A, Cooper ME, Forbes JM. RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol 2009, 20:742-52. 10.1681/ASN.2008050514, 2663823, 19158353.
12. Desco MC, Asensi M, Marquez R, Valls JM, Vento M, Pallardo FV, Sastre J, Vina J. Xanthine oxidase is involved in free radical production in type 1 diabetes. Diabetes 2002, 51:1118-1124. 10.2337/diabetes.51.4.1118, 11916934.
13. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 1999, 48:1-9. 10.2337/diabetes.48.1.1, 9892215.
14. Reshmi H, Pekcetin C, Guner G. Protein sulfhydryl oxidation in short-term diabetic rabbit liver and kidney tissues. Tr J Med Sci 1998, 28:581-582.
15. Kawasaki E, Takino H, Yano M, Uotani S, Matsumoto K, Takao Y, Yamaguchi Y, Akazawa S, Nagataki S. Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes 1994, 43:80-86. 10.2337/diabetes.43.1.80, 8262321.
16. Sohnlein P, Muller M, Syren K, Hartmann U, Bohm BO, Meinck HM, Knip M, Akerblom HK, Richter W. Epitope spreading and a varying but not disease-specific GAD65 antibody response in type I diabetes: the Childhood Diabetes in Finland Study Group. Diabetologia 2000, 43:210-217. 10.1007/s001250050031, 10753043.
17. Shacter E. Quantification and significance of protein oxidation in biological samples. Drug Met Rev 2000, 32:307-26.
18. Gilliam LK, Binder KA, Banga JP, Madec AM, Ortqvist E, Kockum I, Luo D, Hampe CS. Multiplicity of the antibody response to GAD65 in type I diabetes. Clin Exp Immunol 2004, 138:337-341. 10.1111/j.1365-2249.2004.02610.x, 1809224, 15498046.
19. Padoa C, Banga JP, Madec AM, Ziegler M, Schlosser M, Ortqvist E, Kockum I, Palmer J, Rolandsson O, Binder KA, Foote J, Hampe CS. Recombinant Fab of human mAbs specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Ab. Diabetes 2003, 52:2689-2695. 10.2337/diabetes.52.11.2689, 14578287.
20. Kawasaki E, Takino H, Yano M, Uotani S, Matsumoto K, Takao Y, Yamaguchi Y, Akazawa S, Nagataki S. Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes 1994, 43:80-86. 10.2337/diabetes.43.1.80, 8262321.
21. Fenalti G, Hampe CS, Arafat Y, Law RHP, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ. COOH-Terminal Clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity. Diabetes 2008, 57:1293-1301. 10.2337/db07-1461, 18184926.
22. Bradford MM. A rapid and sensitive method for quantitation of micrograms quantity of protein utilizing the principle of protein dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.
23. Levine RL, Williams J, Stadtman ER, Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 1994, 233:346-357. full_text, 8015469.
24. Khan WA, Habib S, Khan MWA, Alam K, Moinuddin. Enhanced binding of circulating SLE autoantibodies to catecholestrogen-copper-modifed DNA. Mol Cell Biochem 2008, 315:143-150. 10.1007/s11010-008-9798-1, 18543085.
25. Goding JW. Use of staphylococcal protein A as immunological reagent. J Immunol Methods 1978, 20:241-254. 10.1016/0022-1759(78)90259-4, 349081.
26. Langmuir I. The adsorption of gases on plane surface glass, mica and platinum. J Am Chem Soc 1918, 40:1361-1403.