The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line

Cancer Cell International

Volumn 11, Issue , 2011, Pages

  Asher, Viren ^a   Warren, Averil ^a   Shaw, Robert ^a   Sowter, Heidi ^b   Bali, Anish ^a   Khan, Raheela ^a  

^a ROYAL DERBY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DERBY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; CLOFILIUM; ERGTOXIN; IMIPRAMINE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL EAG; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; OVARY CANCER; WESTERN BLOTTING;

EID: 79952348818     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-11-6     Document Type: Article

References (23)

1. Le Guennec JY, Ouadid-Ahidouch H, Soriani O, Besson P, Ahidouch A, Vandier C. Voltage-gated ion channels, new targets in anti-cancer research. Recent Pat Anticancer Drug Discov 2007, 2:189-202. 10.2174/157489207782497244, 18221062.
2. Ganetzky B, Robertson GA, Wilson GF, Trudeau MC, Titus SA. The eag family of K+ channels in Drosophila and mammals. Ann N Y Acad Sci 1999, 868:356-369. 10.1111/j.1749-6632.1999.tb11297.x, 10414305.
3. Pardo LA, del Camino D, Sanchez A, Alves F, Bruggemann A, Beckh S, Stuhmer W. Oncogenic potential of Eag K channels. EMBO J 1999, 18:5540-5547. 10.1093/emboj/18.20.5540, 1171622, 10523298.
4. Camacho J. Ether a go-go potassium channels and cancer. Cancer Lett 2006, 233:1-9. 10.1016/j.canlet.2005.02.016, 16473665.
5. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 1995, 80:795-803. 10.1016/0092-8674(95)90358-5, 7889573.
6. Crociani O, Guasti L, Balzi M, Becchetti A, Wanke E, Olivotto M, Wymore RS, Arcangeli A. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem 2003, 278:2947-2955. 10.1074/jbc.M210789200, 12431979.
7. Zhanping W, Xiaoyu P, Na C, Shenglan W, Bo W. Voltage-gated K+ channels are associated with cell proliferation and cell cycle of ovarian cancer cell. Gynecol Oncol 2007, 104:455-460. 10.1016/j.ygyno.2006.08.033, 17014896.
8. Cancer Research UK Ovarian Cancer incidence statistics. , http://info.cancerresearchuk.org/cancerstats/types/ovary/incidence/index.htm
9. Garcia-Ferreiro RE, Kerschensteiner D, Major F, Monje F, Stuhmer W, Pardo LA. Mechanism of block of hEag1 K+ channels by imipramine and astemizole. J Gen Physiol 2004, 124:301-317. 10.1085/jgp.200409041, 2233905, 15365094.
10. Gessner G, Heinemann SH. Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol 2003, 138:161-171. 10.1038/sj.bjp.0705025, 1573651, 12522086.
11. Roy J, Vantol B, Cowley EA, Blay J, Linsdell P. Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7. Oncol Rep 2008, 19:1511-1516.
12. Pardo-Lopez L, Garcia-Valdes J, Gurrola GB, Robertson GA, Possani LD. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels. FEBS Lett 2002, 510:45-49. 10.1016/S0014-5793(01)03218-5, 11755529.
13. Gurrola GB, Rosati B, Rocchetti M, Pimienta G, Zaza A, Arcangeli A, Olivotto M, Possani LD, Wanke E. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom. FASEB J 1999, 13:953-962.
14. Zhang G, Gurtu V, Kain SR, Yan G. Early detection of apoptosis using a fluorescent conjugate of annexin V. Biotechniques 1997, 23:525-531.
15. Pardo LA, Suhmer W. Eag1 as a cancer target. Expert Opin Ther Targets 2008, 12:837-843. 10.1517/14728222.12.7.837, 18554152.
16. Trudeau MC, Titus SA, Branchaw JL, Ganetzky B, Robertson GA. Functional analysis of a mouse brain Elk-type K+ channel. J Neurosci 1999, 19:2906-2918.
17. Li H, Liu L, Guo L, Zhang J, Du W, Li X, Liu W, Chen X, Huang S. HERG K+ channel expression in CD34+/CD38-/CD123(high) cells and primary leukemia cells and analysis of its regulation in leukemia cells. Int J Hematol 2008, 87:387-392. 10.1007/s12185-008-0056-9, 18415658.
18. Dolderer JH, Schuldes H, Bockhorn H, Altmannsberger M, Lambers C, von Zabern D, Jonas D, Schwegler H, Linke R, Schroder UH. HERG1 gene expression as a specific tumor marker in colorectal tissues. Eur J Surg Oncol 36:72-77.
19. Pardo LA, Contreras-Jurado C, Zientkowska M, Alves F, Stuhmer W. Role of voltage-gated potassium channels in cancer. J Membr Biol 2005, 205:115-124. 10.1007/s00232-005-0776-1, 16362499.
20. Gavrilova-Ruch O, Schonherr K, Gessner G, Schonherr R, Klapperstuck T, Wohlrab W, Heinemann SH. Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J Membr Biol 2002, 188:137-149. 10.1007/s00232-001-0181-3, 12172639.
21. Levkovitz Y, Gil-Ad I, Zeldich E, Dayag M, Weizman A. Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. J Mol Neurosci 2005, 27:29-42. 10.1385/JMN:27:1:029, 16055945.
22. Choi BY, Kim HY, Lee KH, Cho YH, Kong G. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett 1999, 147:85-93. 10.1016/S0304-3835(99)00280-3, 10660093.
23. Todd RC, Lippard SJ. Inhibition of transcription by platinum antitumor compounds. Metallomics 2009, 1:280-291. 10.1039/b907567d, 2752884, 20046924.